Abstract: A mucous membrane-adhering film preparation wherein the film consists of two layers. One layer of the film consists of the pharmaceutical agents and water-soluble high polymer material. The other layer of the film material consists of poor water-soluble agents. The pharmaceutical agent and water-soluble high polymer material layer first layer and the poor water-soluble agents second layer are separately prepared in solvents. The first solution is coated on a base plate having a favorable releasing nature, and, by removing the solvent, the film is produced on the base plate, the second solvent is then coated on the first layer and by removing the solvent, the desired film having one poor water-soluble surface is produced.

Abstract: Nicotinic acid is produced by oxidizing dialkylpyridine such as 2-methyl-5-ethylpyridine, 2,5-lutidine and the like, with nitric acid by an amount of 100 to 118 percent, preferably 100 to 108 percent, to the theoretical oxidizing amount, at a temperature of 220.degree. to 240.degree. C, preferably 225 to 235.degree. C under a pressure of 30 to 45 kg/cm.sup.2 for 5 to 30 minutes.