Abstract: An applicator includes: a liquid medicine container having an opening, and a brush member arranged adjacently to the liquid medicine container to cover the opening. The brush member is made up of a plurality of fibers that are bundled together. The brush member has a tubular shape in a root portion located adjacently to the liquid medicine container, tapers from the root portion toward a top end portion located opposite to the liquid medicine container, and has a wedge shape in the top end portion.

Abstract: The objective of the present invention is to provide a method of preventing an oxygen-caused alteration of a drug in an adhesive patch enclosed inside a packaging container. The present invention is a package body comprising a packaging container and a drug-containing adhesive patch enclosed inside the packaging container, wherein the amount of oxygen gas inside the package body is 20 ?L or less, and the concentration of oxygen gas is 17.0 to 25.0 vol %. This packaging does not have to contain an oxygen scavenger as a separate member distinct from the drug-containing adhesive patch. Further, the amount of oxygen gas may be 4 ?L/mg or less per amount of a drug in the drug-containing adhesive patch.

Abstract: The purpose of the present invention is to provide a rivastigmine-containing adhesive skin patch which has excellent transdermal permeability of rivastigmine contained therein and has excellent adhesion performance. The present invention provides an adhesive skin patch comprising a support and an adhesive agent layer arranged on the support, wherein the adhesive agent layer contains at least rivastigmine and/or a pharmaceutically acceptable salt thereof and a specific acrylic adhesive agent. The adhesive skin patch according to the present invention may be composed of only the support and the adhesive agent layer. The adhesive agent layer may have a single-layered structure.

Abstract: The present invention is directed to a nonaqueous pressure-sensitive adhesive that may be used in medicinal tape preparations for percutaneous absorption. The adhesive may comprise a copolymer obtained by copolymerization of a (meth)acrylic monomer having an acetoacetyl group in the molecule and one or more monomers from among other (meth)acrylic monomers without acetoacetyl groups and copolymerizable vinyl monomers, in a nonaqueous solvent. Suitable (meth)acrylic monomers having an acetoacetyl group in the molecule are acetoacetoxyalkyl methacrylates, and especially 2-acetoacetoxyethyl methacrylate. The pressure-sensitive adhesive of the invention uses no polyamine derivatives, isocyanate compounds, polyvalent metal chelate compounds, etc., as crosslinking agents, and therefore toxicity is not a concern and skin is not irritated. A medicinal tape preparation for percutaneous absorption of the invention has superior adhesive strength and cohesive strength, and is highly safe with low skin irritation.

Abstract: The present invention provides a method for producing paint and a system for producing paint, which enable, in a paint-producing process, moderate stirring and dispersive mixing without causing entrainment of air bubbles, and are also economically advantageous and easier to clean. The system includes a tank 2 for receiving a paint material to be mixed and dispersed, a pump 3 for sucking part of the paint material in the tank 2 and discharging the sucked paint material into the remaining part of the paint material in the tank 2, and a flow path reduction area 5 disposed between the pump 3 and a paint material discharge outlet 4, the discharge outlet 4 being positioned so as to be submerged in the paint material in the tank. This achieves the stirring, mixing, and dispersion.

Abstract: A composition for production of a crosslinkable pressure-sensitive adhesive for skin, obtained by dissolving in a solvent 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth)acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth)acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups.

Abstract: A medical tape preparation which comprises a support and, superposed on one side thereof in the following order, a pressure-sensitive adhesive layer and a release liner. The pressure-sensitive adhesive layer can contain a large amount of an oleophilic oily matter. The tape preparation is excellent in adhesion, cohesiveness, and stability even when no crosslinking agent is used. The pressure-sensitive adhesive layer in the medical tape preparation comprises a blend of two tacky polymers, which are a tacky polymer (A) comprising a copolymer obtained from 2-acetoacetoxyethyl methacrylate and other vinyl monomer(s) as constituent ingredients and a tacky polymer (B) comprising a copolymer which is obtained from a C4-10-alkyl(meth)acrylate and other vinyl monomer(s) as constituent ingredients and is different from the tacky polymer (A).

Abstract: A medical tape preparation which comprises a support and, superposed on one side thereof in the following order, a pressure-sensitive adhesive layer and a release liner. The pressure-sensitive adhesive layer can contain a large amount of an oleophilic oily matter. The tape preparation is excellent in adhesion, cohesiveness, and stability even when no crosslinking agent is used. The pressure-sensitive adhesive layer in the medical tape preparation comprises a blend of two tacky polymers, which are a tacky polymer (A) comprising a copolymer obtained from 2-acetoacetoxyethyl methacrylate and other vinyl monomer(s) as constituent ingredients and a tacky polymer (B) comprising a copolymer which is obtained from a C4-10-alkyl (meth)acrylate and other vinyl monomer(s) as constituent ingredients and is different from the tacky polymer (A).

Abstract: A medical tape preparation which comprises a support and, superposed on one side thereof in the following order, a pressure-sensitive adhesive layer and a release liner. The pressure-sensitive adhesive layer can contain a large amount of an oleophilic oily matter. The tape preparation is excellent in adhesion, cohesiveness, and stability even when no crosslinking agent is used. The pressure-sensitive adhesive layer in the medical tape preparation comprises a blend of two tacky polymers, which are a tacky polymer (A) comprising a copolymer obtained from 2-acetoacetoxyethyl methacrylate and other vinyl monomer(s) as constituent ingredients and a tacky polymer (B) comprising a copolymer which is obtained from a C4-10-alkyl (meth)acrylate and other vinyl monomer(s) as constituent ingredients and is different from the tacky polymer (A).

Abstract: The present invention provides a tulobuterol adhesive patch comprising (a) a support, (b) an acrylic pressure-sensitive adhesive layer containing the percutaneously absorbing drug tulobuterol and if necessary a lipophilic oily plasticizer, and (c) a release liner, laminated in that order, wherein the acrylic pressure-sensitive adhesive is a copolymer obtained by copolymerizing an acrylic monomer which is acetoacetoxyalkyl (meth) acrylate with one or more other vinyl monomers, to yield a tulobuterol adhesive patch with excellent release and skin permeability of tulobuterol from the pressure-sensitive adhesive layer, low skin irritation and excellent safety.

Abstract: A composition for production of a crosslinkable pressure-sensitive adhesive for skin, obtained by dissolving in a solvent 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth)acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth)acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups.

Abstract: A nonaqueous pressure-sensitive adhesive for a medicinal tape preparation for percutaneous absorption comprising (a) a support, (b) a pressure-sensitive adhesive layer containing a drug and a nonaqueous pressure-sensitive adhesive and (c) a release film laminated in that order, and a medicinal tape preparation for percutaneous absorption comprising the adhesive. The nonaqueous pressure-sensitive adhesive may comprise a copolymer obtained by copolymerization of a (meth)acrylic monomer having an acetoacetyl group in the molecule and one or more monomers from among other (meth)acrylic monomers without acetoacetyl groups and copolymerizable vinyl monomers, in a nonaqueous solvent. Suitable (meth)acrylic monomers having an acetoacetyl group in the molecule are acetoacetoxyalkyl methacrylates, and especially 2-acetoacetoxyethyl methacrylate.

Abstract: The present invention provides a method for producing paint and a system for producing paint, which enable, in a paint-producing process, moderate stirring and dispersive mixing without causing entrainment of air bubbles, and are also economically advantageous and easier to clean. The system includes a tank 2 for receiving a paint material to be mixed and dispersed, a pump 3 for sucking part of the paint material in the tank 2 and discharging the sucked paint material into the remaining part of the paint material in the tank 2, and a flow path reduction area 5 disposed between the pump 3 and a paint material discharge outlet 4, the discharge outlet 4 being positioned so as to be submerged in the paint material in the tank. This achieves the stirring, mixing, and dispersion.

Abstract: A skin patch that can enhance the water resistance and handling easiness and can alleviate any irritation on the user. There is provided a skin patch having a flexible backing and, superimposed thereon, a plaster containing a styrene-isoprene-styrene block copolymer and having a glass transition temperature (Tg) of ?45° to ?35° C. and tan ? (lag angle) value, determined at dynamic viscoelasticity measurement (frequency 6.2832 rad/s) at 45° C., of 0.25 or less.

Abstract: A medical tape preparation which comprises a support and, superposed on one side thereof in the following order, a pressure-sensitive adhesive layer and a release liner. The pressure-sensitive adhesive layer can contain a large amount of an oleophilic oily matter. The tape preparation is excellent in adhesion, cohesiveness, and stability even when no crosslinking agent is used. The pressure-sensitive adhesive layer in the medical tape preparation comprises a blend of two tacky polymers, which are a tacky polymer (A) comprising a copolymer obtained from 2-acetoacetoxyethyl methacrylate and other vinyl monomer(s) as constituent ingredients and a tacky polymer (B) comprising a copolymer which is obtained from a C4-10-alkyl (meth)acrylate and other vinyl monomer(s) as constituent ingredients and is different from the tacky polymer (A).

Abstract: It is an object of the invention to provide a crosslinkable pressure-sensitive adhesive for skin that exhibits satisfactory adhesion and releasability for human skin and low irritation to skin, and a crosslinkable pressure-sensitive adhesive sheet for skin that is suitable for medical and cosmetic use, as well as to provide a composition for production of a crosslinkable pressure-sensitive adhesive for skin that has superior storage properties and is suitable for preparation of the crosslinkable pressure-sensitive adhesive for skin. The crosslinkable pressure-sensitive adhesive for skin of the invention is formed by 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth) acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.

Abstract: A nonaqueous pressure-sensitive adhesive for a medicinal tape preparation for percutaneous absorption comprising (a) a support, (b) a pressure-sensitive adhesive layer containing a drug and a nonaqueous pressure-sensitive adhesive and (c) a release film laminated in that order, and a medicinal tape preparation for percutaneous absorption comprising the adhesive. The nonaqueous pressure-sensitive adhesive may comprise a copolymer obtained by copolymerization of a (meth)acrylic monomer having an acetoacetyl group in the molecule and one or more monomers from among other (meth)acrylic monomers without acetoacetyl groups and copolymerizable vinyl monomers, in a nonaqueous solvent. Suitable (meth)acrylic monomers having an acetoacetyl group in the molecule are acetoacetoxyalkyl methacrylates, and especially 2-acetoacetoxyethyl methacrylate.

Abstract: A cationic electro-deposition coating composition, comprises: Component (A): an amino-containing epoxy resin (A) obtained by adding an amino-containing compound (a-2) to an epoxy resin (a-1) having an epoxy equivalent of from 400 to 3000, Component (B): an amino-containing acrylic resin (B) obtained by adding an amino-containing compound (b-4) to a copolymer resin obtained by radical copolymerization of, as essential components, a polylactone-modified hydroxyl-containing radical copolymerizable monomer (b-1), which is obtained by adding a lactone to a hydroxyl-containing acrylic monomer (b), and glycidyl (meth)acrylate (b-2), and another radical copolymerizable monomer (b-3); and Component (C): a blocked polyisocyanate curing agent (C) as a curing component, the component (A), component (B) and component (C) being added in amounts of 5 to 80 wt %, 5 to 80 wt % and 10 to 40 wt %, respectively, based on the total solid content of the components (A), (B) and (C).