Abstract: A cooling device includes: a container in which a refrigerant is sealed; an evaporating part that evaporates the refrigerant in a liquid phase by heat reception inside the container; a condensing part that condenses the refrigerant in a gas phase by heat dissipation inside the container; and a plate-shaped or block-shaped flow path member in which a plurality of flow paths configured to transport the refrigerant in a liquid phase from the condensing part to the evaporating part by surface tension inside the container is formed in parallel.

Abstract: In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.

Abstract: In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.

Abstract: A low cost automotive power window switch having few window operating switches uses a single switch to select which of the four windows to operate, and to control the window locks. The power window switch has a window operating switch 3 for raising and lowering each of the car windows, and a mode selector switch 2 for switching between the windows. The mode selector switch 2 also has a window lock switch function for locking and unlocking the windows.

Abstract: This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's disease. This invention also relates to processes for producing the isochroman compound, which comprises cultivating Penicillium simplicissimum FERM BP-6357 and then isolating the isochroman compound from the fermentation broth. The present invention also relates to a pharmaceutical composition comprising the isochroman compound.

Abstract: The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are independently H, C2-C6 acyl or halo-substituted benzoyl; and R3 is —C(O)O—C1-C6 alkyl, C(O)OH, CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, with the proviso that when R2 is acetyl and R3 is methoxycarbonyl, R1 is not H; and that when R3 is CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, R1 and R2 are H. The present invention also relates to a pharmaceutical composition comprising compound of the present invention, which is useful in the treatment of IL-1 and TNF mediated diseases or the like. The present invention further relates to a process for producing the compounds of the formula (I).

Abstract: A low cost automotive power window switch having few window operating switches uses a single switch to select which of the four windows to operate, and to control the window locks. The power window switch has a window operating switch 3 for raising and lowering each of the car windows, and a mode selector switch 2 for switching between the windows. The mode selector switch 2 also has a window lock switch function for locking and unlocking the windows.

Abstract: The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are independently H, C2-C6 acyl or halo-substituted benzoyl; and R3 is —C(O)O—C1-C6 alkyl, C(O)OH, CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, with the proviso that when R2 is acetyl and R3 is methoxycarbonyl, R1 is not H; and that when R3 is CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, R1 and R2 are H. The present invention also relates to a pharmaceutical composition comprising compound of the present invention, which is useful in the treatment of IL-1 and TNF mediated diseases or the like. The present invention further relates to a process for producing the compounds of the formula (I).

Abstract: This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's disease. This invention also relates to processes for producing the isochroman compound, which comprises cultivating Penicillium simplicissimum FERM BP-6357 and then isolating the isochroman compound from the fermentation broth. The present invention also relates to a pharmaceutical composition comprising the isochroman compound.

Abstract: The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 are independently H, C.sub.2 -C.sub.6 acyl or halo-substituted benzoyl; and R.sup.3 is --C(O)O--C.sub.1 -C.sub.6 alkyl, C(O)OH, CN, CONH.sub.2, CONHCH.sub.3, CON(CH.sub.3).sub.2, 1-methyltetrazole or 2-methyltetrazole, with the proviso that when R.sub.2 is acetyl and R.sup.3 is methoxycarbonyl, R.sup.1 is not H; and that when R.sup.3 is CN, CONH.sub.2, CONHCH.sub.3, CON(CH.sub.3).sub.2, 1-methyltetrazole or 2-methyltetrazole, R.sup.1 and R.sup.2 are H.The present invention also relates to a pharmaceutical composition comprising compound of the present invention, which is useful in the treatment of IL-1 and TNF mediated diseases or the like.The present invention further relates to a process for producing the compounds of the formula (I).

Abstract: This invention provides processes for producing novel cyclic peptide compounds, which comprise cultivating Ctenomyces serratus FERM BP-5731 and then isolating the cyclic peptide compounds from the fermentation broth. The compounds produced by these processes include a cyclic peptide compound of the following formula (I): ##STR1## The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of severe pain, detoxication of narcotics dependency or acute narcotics intoxication or the like.

Abstract: A switch assembly having a switch contact section positioned with high precision by forming positioning portions for the switch contact section on a lower case 28. The lower case 28 is coupled with an upper case 2. Knobs 3, 4, 5, 6, 7 and 8 are pivotally supported on the upper case 2, respectively, and have operation rods 3b, 4c, 5c, 6c, 7c, 8a projected downwardly. The switch contact sections 11, 16, 19, 22, 25 and 26 have operation shafts 11a, 16a, 19a, 22a, 25a and 26a to be contacted with operation rods 3b, 4c, 6c, 7c and 8a, respectively. The lower case 28 is provided with positioning portions 28b, 28c, 28d, 28e, 28f, 28g and 28i for positioning the switch contact sections 11, 16, 19, 22, 25 and 26 at predetermined positions, respectively.

Abstract: A power transmission system having: a power transmission belt with a tensile strength such that a force of at least 17 kgf per 1 mm width is required to effect a 1% elongation of the belt; a plurality of pulleys with which the power transmission belt is operatively engaged; and an auto-tensioner having an element to engage the power transmission belt. The auto-tensioner has a damping ratio that is not greater than 20%, where the damping ratio is defined by the following formula: Damping ratio=2[(A-B)/(A+B)].times.100, where A is the force exerted by the auto-tensioner element during up-stroking of the auto-tensioner element and B is the force exerted by the auto-tensioner element during down-stroking of the idler pulley. More preferably, the damping ratio is 10-20%.

Abstract: An apparatus is provided for tensioning a drive belt, which apparatus consists of tensioner arm having an idler pulley thereon for engagement with the surface of a drive belt, structure for mounting the tensioner arm to a support for pivoting movement in first and second opposite directions relative to the support, and a torsion coil spring formed of wire and acting between the mounting structure and tensioner arm for biasing the tensioner arm in one of the first and second directions. The wire has a non-circular cross section.

Abstract: An apparatus for tensioning a drive belt and having a tensioner arm with structure thereon for engaging a surface of the drive belt, structure for mounting the tensioner arm to a support for pivoting movement about a first axis in first and second opposite directions relative to the support including a roller bearing for guiding relative movement between the tensioner arm and support, and structure for normally biasing the belt in one of the first and second opposite directions relative to the support.

Abstract: A toothed belt power transmission system having a belt tooth configuration and pulley groove configuration providing for clearances between the belt tooth root and pulley groove outer surface, and between the belt tooth tip surface and pulley groove inner surface. A power transmitting surface on a midportion of the tooth has facial engagement with a confronting sidewall surface at the midportion of the pulley groove side surface. Locations of the centers of the different arcuate surfaces of the pulley tooth and belt groove for providing the extended life, low noise operation of the drive are disclosed. A number of different constructions embodying the invention are disclosed.

Abstract: An apparatus for tensioning a belt consisting of a tensioner arm having an idler pulley for engagement with a surface of a drive belt, structure for mounting the tensioner arm to a suppport for pivoting movement about a pivot axis in first and second opposite directions, and structure for biasing the tensioner arm in one of the first and second directions. The mounting structure includes first and second members with first and second relatively movable cooperating friction generating surface for damping rotation of the tensioner arm. At least a portion of one of the friction generating surfaces is concave opening towards the tensioner with at least one of the friction generating surfaces having at least a portion defined by other than a radius centered on the pivot axis of the tensioner arm to thereby produce a greater resistance to rotation of the tensioner arm in the other of the first and second directions than in the one of the first and second tensioner arm pivoting directions.

Abstract: The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.

Abstract: The invention relates to treatment of diseases caused by thromboxane A.sub.2 comprising administering a compound ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl andR.sup.3 is --CH.dbd.N--R.sup.4 in which R.sup.4 is arylureido or arylthioureido andX is --O--,or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to novel compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkoxycarbonyl, phenylsulfonyl, phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, nitro, lower alkoxy, mono (or di or tri)halo(lower)alkyl and lower alkyl, phenylcarbamoyl, lower alkylsulfonyl, benzoyl or thienylsulfonyl;R.sup.2 is phenylsulfonyl or phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono(or di or tri)halo(lower)alkyl,R.sup.3 is carboxy(lower)alkyl, lower alkyl substituted with carboxy and 1 to 3 halogen atom(s), esterified carboxy(lower)alkyl, carbamoyl(lower)alkyl, lower alkylsulfonylcarbamoyl(lower)alkyl, phenylsulfonylcarbamoyl(lower)alkyl, carboxyphenyl, esterified carboxyphenyl, carboxy, esterified carboxy, hydroxy(lower)alkyl, sulfino(lower)alkyl, phosphono(lower)alkyl, di(lower)alkoxyphosphoryl(lower)alkyl or halo(lower)alkyl,R.sup.