Patents by Inventor Hideya Mizufune
Hideya Mizufune has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230088365Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: October 7, 2022Publication date: March 23, 2023Inventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
-
Patent number: 11498898Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: September 15, 2020Date of Patent: November 15, 2022Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
-
Publication number: 20210070705Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: September 15, 2020Publication date: March 11, 2021Inventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
-
Publication number: 20200115336Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: November 22, 2019Publication date: April 16, 2020Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
-
Publication number: 20190127324Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: November 26, 2018Publication date: May 2, 2019Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
-
Patent number: 10173977Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: January 13, 2016Date of Patent: January 8, 2019Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
-
Publication number: 20180009746Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: January 13, 2016Publication date: January 11, 2018Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
-
Publication number: 20140303378Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: June 12, 2014Publication date: October 9, 2014Inventors: Tomomi IKEMOTO, Hideya MIZUFUNE, Toshiaki NAGATA, Misayo SERA, Naohiro FUKUDA, Takeshi YAMASAKI
-
Publication number: 20110306769Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: February 24, 2010Publication date: December 15, 2011Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
-
Publication number: 20090326229Abstract: To provide methods for preparing alpha-carboline derivatives in few steps, as well as conveniently and industrially advantageously.Type: ApplicationFiled: August 2, 2007Publication date: December 31, 2009Applicant: Takeda Phamaceutical Company LimitedInventors: Masahiro Mizuno, Hideya Mizufune, Misayo Sera, Masahiro Mineno, Tsuyoshi Ueda
-
Publication number: 20060148858Abstract: A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, —O—, —S— and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents —OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.Type: ApplicationFiled: May 22, 2003Publication date: July 6, 2006Inventors: Tsuyoshi Maekawa, Ryoma Hara, Hiroyuki Odaka, Hiroyuki Kimura, Hideya Mizufune, Kohji Fukatsu
-
Patent number: 6100403Abstract: A method of producing a compound represented by the formula: ##STR1## wherein R.sup.1 stands for hydrogen or an optionally substituted alkyl or acyl group, which comprises reacting a compound represented by the formula: ##STR2## wherein R.sup.1 is of the same meaning as defined above, and R.sup.2 stands for an optionally halolgenated alkyl group or an optionally substituted phenyl group with a compound represented by the formula: ##STR3## in a lower alcohol in the presence of an alkali metal or alkaline earth metal carbonate; the compound (III) being useful as starting compounds for producing thiazolidinedione derivatives having hypoglycemic and hypolipidemic activities.Type: GrantFiled: April 12, 1999Date of Patent: August 8, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Yuzuru Saito, Hideya Mizufune, Makoto Yamashita
-
Patent number: 5952509Abstract: A method of producing a compound represented by the formula: ##STR1## wherein R.sup.1 stands for hydrogen or an optionally substituted alkyl or acyl group, which comprises reacting a compound represented by the formula: ##STR2## wherein R.sup.1 is of the same meaning as defined above, and R.sup.2 stands for an optionally halolgenated alkyl group or an optionally substituted phenyl group with a compound represented by the formula: ##STR3## in a lower alcohol in the presence of an alkali metal or alkaline earth metal carbonate; the compound (III) being useful as starting compounds for producing thiazolidinedione derivatives having hypoglycemic and hypolipidemic activities.Type: GrantFiled: June 23, 1997Date of Patent: September 14, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Yuzuru Saito, Hideya Mizufune, Makoto Yamashita