Patents by Inventor Hideyuki Akaza

Hideyuki Akaza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9717687
    Abstract: [Problem] To provide: a lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration, contains a lipid that is bound to a peptide composed of multiple arginine residues as a constituent lipid, and includes a bacterial cell component having dispersibility in a non-polar solvent; and a method for producing a lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration and includes a substance of interest having dispersibility in a non-polar solvent. [Solution] A lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration, contains a lipid that is bound to a peptide composed of multiple arginine residues as a constituent lipid, and includes a bacterial cell component having dispersibility in a non-polar solvent.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: August 1, 2017
    Assignees: National University Corporation Hokkaido University, Japan BCG Laboratory, University of Tsukuba
    Inventors: Hideyoshi Harashima, Takashi Nakamura, Masafumi Fukiage, Megumi Higuchi, Hideyuki Akaza, Jun Miyazaki, Akihiro Nakaya
  • Publication number: 20150245997
    Abstract: [Problem] To provide: a lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration, contains a lipid that is bound to a peptide composed of multiple arginine residues as a constituent lipid, and includes a bacterial cell component having dispersibility in a non-polar solvent; and a method for producing a lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration and includes a substance of interest having dispersibility in a non-polar solvent. [Solution] A lipid membrane structure which has such a particle diameter that the lipid membrane structure can be sterilized by filtration, contains a lipid that is bound to a peptide composed of multiple arginine residues as a constituent lipid, and includes a bacterial cell component having dispersibility in a non-polar solvent.
    Type: Application
    Filed: August 27, 2013
    Publication date: September 3, 2015
    Inventors: Hideyoshi Harashima, Takashi Nakamura, Masafumi Fukiage, Megumi Higuchi, Hideyuki Akaza, Jun Miyazaki, Akihiro Nakaya
  • Patent number: 9080197
    Abstract: An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equol in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equol and a method of detecting the same. Provided are an equol concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equol concentration-raising or reducing agent; a method of raising or reducing the concentration of equol by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equol; and a method of detecting a microorganism having conversion ability to equol by use of the selective medium.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: July 14, 2015
    Assignee: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Koji Nomoto, Hideyuki Akaza
  • Patent number: 8992947
    Abstract: The present invention developed a novel antitumor agent for renal cell carcinoma that cannot be fully treated by the existing therapies. The present invention provides an antitumor agent comprising a combination drug of tegafur/gimeracil/oteracil potassium that ensures an excellent therapeutic effect in renal cell carcinoma patients that is superior to that of the existing therapies, by way of selecting the patients based on thymidylate synthase.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: March 31, 2015
    Assignee: Taiho Pharmaceutical Co., Ltd.
    Inventors: Hideyuki Akaza, Seiji Naito, Toshinori Oka
  • Patent number: 8420073
    Abstract: The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: April 16, 2013
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Hirokazu Tsuji, Koji Nomoto, Kaoru Moriyama, Hideyuki Akaza
  • Publication number: 20120101102
    Abstract: The present invention developed a novel antitumor agent for renal cell carcinoma that cannot be fully treated by the existing therapies. The present invention provides an antitumor agent comprising a combination drug of tegafur/gimeracil/oteracil potassium that ensures an excellent therapeutic effect in renal cell carcinoma patients that is superior to that of the existing therapies, by way of selecting the patients based on thymidylate synthase.
    Type: Application
    Filed: April 22, 2010
    Publication date: April 26, 2012
    Applicant: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Hideyuki Akaza, Seiji Naito, Toshinori Oka
  • Publication number: 20110318309
    Abstract: The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
    Type: Application
    Filed: February 25, 2010
    Publication date: December 29, 2011
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Koji Nomoto, Kaoru Moriyama, Hideyuki Akaza
  • Publication number: 20100166840
    Abstract: The object is to provide a liposome by which a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW) can be pharmaceutically prepared in a form applicable to a living body (i.e., a form in which the bacterial cell component can be dispersed in an aqueous solvent and has a controlled size) without using any surfactant. Disclosed is a liposome having a lipid membrane containing a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW).
    Type: Application
    Filed: May 11, 2007
    Publication date: July 1, 2010
    Applicants: JAPAN BCG LABORATORY, UNIVERSITY OF TSUKUBA, National University Corporation Hokkaido University
    Inventors: Homhuan Atthachai, Kentaro Kogure, Hideyoshi Harashima, Ikuya Yano, Yoshio Hatakeyama, Hidehiro Yokomizo, Hideyuki Akaza
  • Publication number: 20090253643
    Abstract: An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equal in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equal and a method of detecting the same. Provided are an equal concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equal concentration-raising or reducing agent; a method of raising or reducing the concentration of equal by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equal; and a method of detecting a microorganism having conversion ability to equal by use of the selective medium.
    Type: Application
    Filed: November 2, 2006
    Publication date: October 8, 2009
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Koji Nomoto, Hideyuki Akaza