Patents by Inventor Hilel Lewis
Hilel Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8207262Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.Type: GrantFiled: September 15, 2008Date of Patent: June 26, 2012Assignee: The Cleveland Clinic FoundationInventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq B. Darr, Kiyotaka Fukamachi, Richard A. Gross, David Haynes, Keiji Kamohara, Daniel P. Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
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Publication number: 20090143766Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.Type: ApplicationFiled: January 29, 2009Publication date: June 4, 2009Applicant: The Cleveland Clinic FoundationInventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq B. Darr, Kiyotaka Fukumachi, Richard A. Gross, David Haynes, Keiji Kamohara, Daniel P. Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
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Publication number: 20090142309Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.Type: ApplicationFiled: January 29, 2009Publication date: June 4, 2009Applicant: The Cleveland Clinic FoundationInventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq B. Darr, Kiyotaka Fukamachi, Richard A. Gross, David Haynes, Keiji Kamohara, Daniel P. Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
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Publication number: 20090042294Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.Type: ApplicationFiled: September 15, 2008Publication date: February 12, 2009Applicant: The Cleveland Clinic FoundationInventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq B. Darr, Kiyotaka Fukamachi, Richard A. Gross, David Haynes, Keiji Kamohara, Daniel P. Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
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Patent number: 7465766Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.Type: GrantFiled: July 7, 2005Date of Patent: December 16, 2008Assignee: The Cleveland Clinic FoundationInventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq B. Darr, Kiyotaka Fukamachi, Richard A. Gross, David Haynes, Keiji Kamohara, Daniel P. Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
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Publication number: 20070129623Abstract: An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner.compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: ApplicationFiled: January 30, 2007Publication date: June 7, 2007Inventors: Aaron Fleischman, Shuvo Roy, Hilel Lewis
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Patent number: 7169106Abstract: An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: GrantFiled: May 7, 2004Date of Patent: January 30, 2007Assignee: The Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy, Hilel Lewis
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Publication number: 20060084759Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.Type: ApplicationFiled: July 7, 2005Publication date: April 20, 2006Applicant: The Cleveland Clinic FoundationInventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq Darr, Kiyotaka Fukamachi, Richard Gross, David Haynes, Keiji Kamohara, Daniel Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
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Publication number: 20040207808Abstract: An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: ApplicationFiled: May 7, 2004Publication date: October 21, 2004Applicant: The Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy, Hilel Lewis
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Patent number: 6749568Abstract: An apparatus for measuring intraocular pressure (IOP) comprises a contact lens including an inner surface contoured to a surface portion of an eye and a sensor disposed in the contact lens. The sensor comprises a contact surface for making contact with the surface portion of the eye. The contact surface includes an outer non-compliant region and an inner compliant region fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor further comprises a region of conductive material electrically coupled to the impedance element of the compliant region and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: GrantFiled: April 22, 2002Date of Patent: June 15, 2004Assignee: Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy, Hilel Lewis
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Publication number: 20020193674Abstract: An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: ApplicationFiled: April 22, 2002Publication date: December 19, 2002Applicant: The Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy, Hilel Lewis