Patents by Inventor Hilmar Ebersbach

Hilmar Ebersbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLUBILIZED APYRASES, METHODS AND USE
    Publication number: 20220356455
    Abstract: The invention relates to design and therapeutic use of solubilized apyrase polypeptides, pharmaceuticals compositions, therapeutic uses and methods useful for preventing and treating tissue damage.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 10, 2022
    Inventors: Agostino CIRILLO, Hilmar EBERSBACH, Boerje HARALDSSON, Thomas HUBER, Guido JUNGE, Regina LINK, Max WARNCKE, Chao ZOU
  • NKG2D FUSION PROTEINS AND USES THEREOF
    Publication number: 20220348632
    Abstract: Provided are NKG2D fusion proteins and their uses for the treatment of various diseases.
    Type: Application
    Filed: September 16, 2020
    Publication date: November 3, 2022
    Inventors: Ryan Sullivan, Hilmar Ebersbach, Emilie Ramondou, Philip Egger
  • MULTISPECIFIC MOLECULES TARGETING CLL-1
    Publication number: 20210198368
    Abstract: The present invention is directed to multispecific/multivalent molecules comprising an anti-CLL-1 binding domain.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 1, 2021
    Inventors: Michael DALEY, Hilmar EBERSBACH, Julia JASCUR, Qilong WU, Qiumei YANG, Jiquan ZHANG
  • Rodent combinatorial antibody libraries
    Patent number: 10919955
    Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: February 16, 2021
    Assignee: MORPHOSYS AG
    Inventors: Josef Prassler, David Ott, Stefanie Thiel, Yvonne Stark, Ute Keck, Thomas Pietzonka, Hilmar Ebersbach
  • SINGLE CHAIN PROTEINS WITH C-TERMINAL MODIFICATIONS
    Publication number: 20180106790
    Abstract: The invention pertains to an isolated VH single domain antibody comprising a C-terminal modification, where the C-terminal modification comprises a deletion of at least one amino acid residue that eliminates the interaction of a pre-existing antibody with the single domain antibody without interfering with the binding of the single domain antibody with its target.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 19, 2018
    Applicant: Novartis AG
    Inventors: Andreas LOEW, Hilmar EBERSBACH
  • RODENT COMBINATORIAL ANTIBODY LIBRARIES
    Publication number: 20170183395
    Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
    Type: Application
    Filed: March 10, 2017
    Publication date: June 29, 2017
    Inventors: Josef Prassler, David Ott, Stefanie Thiel, Yvonne Stark, Ute Keck, Thomas Pietzonka, Hilmar Ebersbach
  • Rodent combinatorial antibody libraries
    Patent number: 9650432
    Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: May 16, 2017
    Assignee: MORPHOSYS AG
    Inventors: Josef Prassler, David Ott, Stefanie Thiel, Yvonne Stark, Ute Keck, Thomas Pietzonka, Hilmar Ebersbach
  • SINGLE CHAIN PROTEINS WITH C-TERMINAL MODIFICATIONS
    Publication number: 20140161796
    Abstract: The invention pertains to an isolated VH single domain antibody comprising a C-terminal modification, where the C-terminal modification comprises a deletion of at least one amino acid residue that eliminates the interaction of a pre-existing antibody with the single domain antibody without interfering with the binding of the single domain antibody with its target.
    Type: Application
    Filed: September 13, 2013
    Publication date: June 12, 2014
    Inventors: Andreas LOEW, Hilmar EBERSBACH
  • Rodent Combinatorial Antibody Libraries
    Publication number: 20130030157
    Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
    Type: Application
    Filed: January 28, 2011
    Publication date: January 31, 2013
    Applicant: MORPHOSYS AG
    Inventors: Josef Prassler, David Ott, Stefanie Thiel, Yvonne Stark, Ute Keck, Thomas Pietzonka, Hilmar Ebersbach
  • Ubiquitin or gamma-crystalline conjugates for use in therapy, diagnosis and chromatography
    Patent number: 7838629
    Abstract: The present invention relates to conjugates containing a covalent linkage between one or more polypeptide molecules based on gamma-crystallin or ubiquitin and one or more functional components. Furthermore, the present invention relates to a method for the preparation of such a conjugate as well as to the use of the conjugate in diagnostics, therapy and chromatography.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: November 23, 2010
    Assignee: Scil Proteins GmbH
    Inventors: Erik Fiedler, Hilmar Ebersbach, Thomas Hey, Ulrike Fiedler
  • Ubiquitin or gamma-crystalline conjugates for use in therapy, diagnosis and chromatography
    Publication number: 20070248536
    Abstract: The present invention relates to conjugates containing a covalent linkage between one or more polypeptide molecules based on gamma-crystallin or ubiquitin and one or more functional components. Furthermore, the present invention relates to a method for the preparation of such a conjugate as well as to the use of the conjugate in diagnostics, therapy and chromatography.
    Type: Application
    Filed: April 4, 2007
    Publication date: October 25, 2007
    Inventors: Erik Fiedler, Hilmar Ebersbach, Thomas Hey, Ulrike Fiedler