Patent number: 9205089
Abstract: Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet.
Type:
Grant
Filed:
April 27, 2012
Date of Patent:
December 8, 2015
Assignee:
Massachusetts Institute of Technology
Inventors:
Bernhardt Levy Trout, Trevor Alan Hatton, Emily Chang, James M B Evans, Salvatore Mascia, Won Kim, Ryan Richard Slaughter, Yi Du, Himanshu Hemant Dhamankar, Keith M. Forward, Gregory C. Rutledge, Mao Wang, Allan Stuart Myerson, Blair Kathryn Brettmann, Nikhil Padhye, Jung-Hoon Chun
Publication number: 20120305174
Abstract: Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet.
Type:
Application
Filed:
April 27, 2012
Publication date:
December 6, 2012
Applicant:
Massachusetts Institute of Technology
Inventors:
Bernhardt Levy Trout, Trevor Alan Hatton, Emily Chang, James MB Evans, Salvatore Mascia, Won Kim, Ryan Richard Slaughter, Yi Du, Himanshu Hemant Dhamankar, Keith M. Forward, Gregory C. Rutledge, Mao Wang, Allan Stuart Myerson, Blair Kathryn Brettmann, Nikhil Padhye, Jung-Hoon Chun