Patents by Inventor Hira L. Nakhasi

Hira L. Nakhasi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230039456
    Abstract: Disclosed herein are modified Leishmania species and compositions thereof, such as live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions. Further disclosed are methods related to the modified Leishmania species, such as methods of production and methods of use.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 9, 2023
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Ohio State Innovation Foundation
    Inventors: Hira L. Nakhasi, Ranadhir Dey, Sreenivas Gannavaram, Subir Karmakar, Gregory Matlashewski, Abhay Satoskar, Wen-Wei Zhang, Patrick Lypaczewski
  • Patent number: 8877213
    Abstract: Targeted disruption of the centrin gene leads to attenuation of growth in the Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: November 4, 2014
    Assignees: The United States of America as Represented by the Secretary of the Department of Health and Human Services, Indian Council of Medical Research
    Inventors: Hira L. Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert C. Duncan, Poonam Salotra, Gannavaram Sreenivas
  • Publication number: 20110081383
    Abstract: Targeted disruption of the centrin gene leads to attenuation of growth in the Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
    Type: Application
    Filed: November 15, 2010
    Publication date: April 7, 2011
    Applicants: The Gov. of the United States as Represented by the Secretary, Dept. of Health and Human Services, Institute of Pathology (ICMR)
    Inventors: Hira L. Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert C. Duncan, Poonam Salotra, Gannavaram Sreenivas
  • Patent number: 7887812
    Abstract: Targeted disruption of the centrin gene leads to attenuation of growth in Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: February 15, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Hira L. Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert C. Duncan, Poonam Salotra, Gannavaram Sreenivas