Abstract: A rotation speed information detection apparatus, including: a wheel sensor for detecting passage of teeth of a gear provided in association with tires of a vehicle; a number-of-teeth calculation means for calculating the number of teeth of the gear passed per a sampling cycle set in advance; and a wheel speed calculation means for regularly calculating rotation speed information of the tire with using the number of teeth calculated. The number-of-teeth calculation means is configured to use a ratio between time information at the point and a remaining time until the time at which the next sampling cycle is started is reached to thereby calculate the number of remaining teeth to calculate the number of teeth passed during the sampling cycle.

Abstract: An apparatus for detecting a decrease in a tire air pressure includes; a rotation velocity information detection means for regularly detecting tire rotation velocity information regarding the respective wheels of a vehicle; a resonance frequency estimation means for estimating a resonance frequency of the rotation velocity information based on the rotation velocity information obtained by the rotation velocity information detection means; and a determination means for determining, based on the estimated resonance frequency, a decrease in the tire air pressure. The apparatus includes a data rejecting means for rejecting data of rotation velocity information hindering the estimation of the resonance frequency.

Abstract: The invention includes: a rotation velocity information detection means for regularly detecting tire rotation velocity information regarding the respective wheels of a vehicle; a frequency characteristic estimation means for estimating a frequency characteristic of the rotation velocity information based on the rotation velocity information obtained from the rotation velocity information detection means; and a determination means for determining a decrease in the air pressure of the tire based on the estimated frequency characteristic. The frequency characteristic estimation means is configured to extract a resonance peak of the rotation velocity information by calculating a gain corresponding to an arbitrary frequency.

Abstract: Disclosed is a method for stabilizing a carbodiimide derivative (1) which is a condensing agent useful for production of general synthetic chemical products. Also disclosed is a stabilized composition of the carbodiimide derivative. The method is characterized in that the carbodiimide derivative (1) is handled in an atmosphere wherein the concentration of molecular oxygen in the gas phase within a container is set at not more than 3% by volume and/or in the co-presence of at least one compound selected from the group consisting of antioxidants, N-oxyl compounds, sulfur compounds, amines and Lewis acids.

Abstract: An apparatus for detecting a decrease in a tire air pressure includes: a rotation velocity information detection means for periodically detecting tire rotation velocity information for the respective wheels of a vehicle; a frequency characteristic estimate means for estimating, based on this rotation velocity information, a frequency characteristic of the rotation velocity information; and a judgment means for judging, based on the estimated frequency characteristic, a decrease in the air pressure of the tire.

Abstract: A method for warning deflation of tires which can detect the deflation of 2 wheels at the same axle including a following axle, the simultaneous deflation of 4 wheels or the abrasion of tires only by the information of wheel speeds is provided.

Abstract: In a fluorescent display tube, a metal spacer is used as a height sustaining member and a fixing member of linear member so that the fixing strength of the linear member in the lengthwise direction is increased. In the fluorescent display tube, both ends of filament and Al wires are bonded onto a cathode electrode formed on a substrate by ultrasonic bonding. The ends of the filament are embedded in a part in the Al wires in the shape of being bent into a letter Z or an inverted letter Z to form fixing portion.

Abstract: An electron tube includes a vessel, a primary linear member installed in the vessel, an electrode disposed in the vessel, a first auxiliary linear member and a second auxiliary linear member disposed at different heights to interpose the primary linear member therebetween, and a plurality of fixing members. The fixing members are formed at a single substrate for constituting a part of the vessel, for fixing end portions of the first auxiliary and the second auxiliary linear member thereto.

Abstract: The present invention provides products and methods for modulating expression of a target gene in a cell. One such method includes introducing into the cell a polynucleotide that forms a duplex region with an mRNA transcribed from said target gene, where the duplex region comprises a mammalian miRNA target region. Another such method includes introducing into the cell an siRNA that forms a duplex region with an miRNA, or precursor thereof, where an mRNA transcribed from the target gene comprises a miRNA target region. In certain preferred embodiments, the methods further include measuring expression of the target gene. The methods are particularly useful for modulating ontogenesis, function, differentiation and/or viability of a mammalian cell.

Abstract: The present invention provides a process for simply producing an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines from inexpensive raw materials. An optically active 2-hydroxymethyl-3-phenylpropionic acid ester derivative which can be relatively easily obtained by asymmetric reduction reaction with an enzyme is cyclized to an optically active P-lactone derivative which is then reacted with a sulfur compound to produce an optically active 2-thiomethyl-3-phenylpropionic acid derivative in high yield.

Abstract: The present inventors discovered that an RNA molecule can be efficiently transferred into cytoplasm and exert RNAi effects, by producing a stem loop RNA molecule from the DNA that encodes this RNA molecule, with the use of a tRNA promoter. Also, the RNAi effects can be exerted effectively, by introducing a cytoplasm translocation signal sequence into the DNA that encodes a stem loop RNA molecule. Moreover, the RNAi effects can be exerted effectively by transferring a transcriptional product into the cytoplasm, using a pol II-type promoter. In this case, cytotoxicity can be reduced by co-expressing a Dicer gene. Furthermore, an effective dsRNA can be constructed by treating a dsRNA or a stem loop RNA molecule with Dicer protein. Knockout cells lacking a gene of interest can be conveniently constructed, using these stem-loop RNA molecule expression systems.

Abstract: The present inventors found that in human cells, synthetic small interfering RNAs (siRNAs) targeted to a region containing the CpG islands on gene promoters will specifically induce the methylation of CpG sequences within the target region or adjacent regions. Methylation of the promoters results in suppression at a transcriptional level of expression of genes downstream of the promoters. The present invention provides methods for inducing DNA methylation using the siRNAs, and methods for suppressing gene expression based on siRNA-directed methylation of promoters. The present invention also provides DNA methylation-inducing agents or gene expression-suppressing agents that comprise siRNAs or expression vectors for the siRNAs or dsRNAs.

Abstract: An electron tube includes at least one metal film formed on a base, at least one linear member provided above the base, and at least one additional member for connecting said at least one linear member to said at least one metal film. The at least one linear member is connected to the at least one metal film by welding the at least one additional member to the at least one metal film.

Abstract: The present invention describes the identification, isolation, sequencing and characterization of two human CalDAG-GEF, and two human cAMP-GEF genes, which are associated with the Ras pathway. Also identified are CalDAG-GEF gene homologues in mice and cAMP-GEF gene homologues in rats. Nucleic acids and proteins comprising or derived from the CalDAG-GEFs and/or cAMP-GEFs are useful in screening and diagnosing certain Ras-associated cancers, in identifying and developing therapeutics for treatment of certain Ras-associated cancers, and in producing cell lines and transgenic animals useful as models of Ras-associated cancers.

Abstract: A method for warning deflation of tires which can detect the deflation of 2 wheels at the same axle including a following axle, the simultaneous deflation of 4 wheels or the abrasion of tires only by the information of wheel speeds is provided.

Abstract: A process for easily and industrially advantageously producing a high-purity 2-aralkyl-3-acetylthiopropionic acid and a high-purity 2-aralkylpropionic acid having a leaving group in the 3-position from easily available compounds. A 2-aralkyl-1-propanol having a sulfonyloxy group or halogen atom in the 3-position is oxidized with a permanganate under acidic conditions to produce a high-purity 2-aralkylporpionic acid having sulfonyloxy or the halogen in the 3-position. This acid is reacted with a thioacetate in the presence of water to produce a high-purity 2-aralkyl-3-acetylthiopropionic acid.

Abstract: A fluorescent luminous tube includes a vacuumed envelope having two base members, an anode and a cathode installed inside the vacuumed envelope, a first and a second metal layer formed on one of the two base members, a wire shaped member mounted inside the vacuumed envelope, and a first and a second spacer, made of a metal, for supporting the wire shaped member at a predetermined height. One end portion of the wire shaped member is wound around the first spacer to be supported at the predetermined height and is interposed between the first spacer and the first metal layer to be fixed thereto. Further, the other end portion of the wire shaped member is supported at the predetermined height by the second spacer and is fixed to the second metal.

Abstract: An object of the present invention is to provide a maxizyme that can bind to a target mRNA regardless of its conformation, and can effectively cleave the mRNA. The present invention provides a maxizyme which binds to a molecule having helicase activity.

Abstract: In a display for measurement devices for use in displaying a pointer image of a measurement, a movement of the pointer image is smooth and a visual perception of the pointer image is improved. As shown in FIG. 1A, a display segment group S formed of sub pointer image display segment columns is arranged along scales M in a semicircular shape (a fanwise shape). The pointer image P is made of four sub pointer image display segment columns Sx+1 to Sx+4. In case the pointer image P is moved from the position marked by the bold solid line to that represented by a bold dashed line, a new pointer image is made of sub pointer image display segment columns Sx+2 to Sx+5. In other words, the pointer image is moved in a unit of a sub pointer image display segment column.

Abstract: A fluorescent luminous tube includes a plurality of cathode filaments, a multiplicity of a cathode wirings, each cathode wiring including one or more terminal portions and a wiring portion and being formed of a metal layer, and one or more intermediate portions, each being made of a metal layer. The cathode filament is grouped into at least one set of one or more filaments and filaments in each set are connected in series by fixing an end portion thereof on a terminal portion or an intermediate portion by ultrasonic wire bonding or ultrasonic bonding.