Abstract: The present invention provides methods of preventing and/or treating multiple organ failure comprising the step of administering a therapeutically effective amount of agent comprising tumor cytotoxic factor-II (TCF-II) or hepatocyte growth factor (HGF). Methods of the present invention will be useful for preventing and/or treating the development of multiple organ failure resulting from burn, disseminated intravascular coagulation (DIC), circulatory failure, hemorrhagic shock, infectious disease, acute pancreatitis, ischemic disorder, hepatorenal syndrome, gastrointestinal hemorrhage, nutritional metabolic failure, terminal cancer, acquired immunodeficiency syndrome (AIDS), deterioration of systemic conditions due to radiation affection, and cachexia.

Abstract: The present invention is to provide an agent for preventing and/or treating multiple organ failure comprising Tumor cytotoxic factor-II (TCF-II) or Hepatocyte growth factor (HGF) as an effective ingredient.

Abstract: Novel dry skin remedies useful for treatment dry skin, containing as the active ingredient spiro [oxathiolane-quinuclidine] derivatives represented by general formula (I) or acid addition salts thereof, desirably cis-2-methylspiro [1,3-oxathiolane-5,3′-quinuclidine] hydrochloride. The remedies promote the secretion of sebaceous and sweat glands through oral or parenteral administration to treat dry skin, thus being useful as drugs.

Abstract: Novel dry skin remedies useful for treatment dry skin, containing as the active ingredient spiro [oxathiolane-quinuclidine] derivatives represented by general formula (I) or acid addition salts thereof, desirably cis-2-methylspiro [1,3-oxathiolane-5,3′-quinuclidine] hydrochloride. The remedies promote the secretion of sebaceous and sweat glands through oral or parenteral administration to treat dry skin, thus being useful as drugs.

Abstract: The present invention is to provide an agent for preventing and/or treating multiple organ failure comprising Tumor cytotoxic factor-II (TCF-II) or Hepatocyte growth factor (HGF) as an effective ingredient.

Abstract: A preventative and/or therapeutic agent to treat and/or prevent organ failure due to mercury exposure, contains as the active ingredient a mutant tumor cytotoxic factor protein (TCF-II). The therapeutic agent comprises a mutant TCF-II protein according to SEQ ID NO. 2 in which amino acid residues Arg-Lys-Arg-Arg have been replaced by Ala-Ala-Ala-Ala, or in which amino acids Lys-Ile-Lys-Thr-Lys-Lys have been replaced by Ala-Ile-Ala-Thr-Ala-Ala (SEQ ID NO. 3).

Abstract: Blood coagulation normalizing agents comprising effective ingredient of TCF-II.The blood coagulation normalizing agents of the present invention comprised of glycoprotein TCF-II produced by human fibroblast cells and accelerates the production of blood coagulation factor and increases platelet count to treat abnormal blood coagulation such as disseminated intravascular coagulation (DIC) and decreased platelet count caused by administration of cisplatin.

Abstract: Modified TCF in which one or more amino-acid residues of the wild type TCF responsible for glycosylation are substituted or deleted so that at least one N-linked oligosaccharide chain is removed. The modified TCFs have a longer biological half-lives without loss of their biological activities. The modified TCFs are therapeutically important as agents for liver diseases or as anti-cancer drugs.

Abstract: A press roll apparatus temporarily or finally bonds two glass sheets with an adhesive intermediate film sandwiched therebetween to manufacture a laminated glass. The press roll apparatus has a plurality of drive roll units each having a pair of upper and lower presser rolls operatively coupled to a drive source and rotatable thereby for pressing the glass sheets therebetween, and a plurality of free roll units each having a pair of upper and lower presser rolls freely rotatable for pressing the glass sheets therebetween. The drive roll units and the free roll units are housed in a frame and vertically positionally adjustably supported by the frame, the frame having a pair of horizontal shafts projecting outwardly. The frame is supported on a support frame by the horizontal shafts for angular movement about the horizontal shafts, the support frame having a pair of horizontally spaced vertical support columns.

Abstract: An automatic loading system includes an automatic loading apparatus for automatically loading, onto a pallet, a glass sheet product as it lies substantially horizontally and is delivered along a feed path to a terminal position of the feed path. The automatic loading apparatus has a suction mechanism for attracting the lower surface of the glass sheet product at the terminal position and for moving the glass sheet product to a loading position to load the glass sheet product onto the pallet. The automatic loading system also includes an apparatus for putting an interleaving sheet on an upper surface of the glass sheet product in the feed path. The interleaving sheet putting apparatus comprises a mechanism for moving an uppermost interleaving sheet of a stack of interleaving sheets over the glass sheet product, and a holder mechanism for holding the uppermost interleaving sheet against an upper surface of the glass sheet product.

Abstract: While a heated glass sheet moves through a quenching section, the glass sheet is blown with air in the same portions so as to be quenched always in the same portions to provide on the glass surface rapidly cooled portions and uncooled portions. Thereby the residual strains on the glass surface are made different to prevent the generation of pieces or splines when the glass sheet is broken.