Patents by Inventor Hiroaki Motoyama
Hiroaki Motoyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240157478Abstract: A high-speed steel sintered body includes, a base, a solidified layer continuously disposed on a surface of the base. The base is constituted by high-speed steel, the solidified layer is constituted by high-speed steel whose composition is different from a composition of the high-speed steel constituting the base, and a boundary between the base and the solidified layer is not visually identified in a 200× magnified observation image of a section intersecting the surface.Type: ApplicationFiled: December 23, 2021Publication date: May 16, 2024Applicant: Sumitomo Electric Sintered Alloy, Ltd.Inventors: Takanori OOTAKI, Hiroaki MOTOYAMA
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Patent number: 11331850Abstract: A method for manufacturing a shaped article includes a step of providing a high-speed steel powder, a step of forming a powder layer by spreading the powder, a step of forming a solidified layer in which the powder is in a bound state by irradiating the powder layer with a scanning laser beam, and a step of stacking up solidified layers by sequentially repeating the step of forming a powder layer and the step of forming a solidified layer, thereby forming the shaped article. The laser beam has an energy density of 60 J/mm3 or more and less than 600 J/mm3.Type: GrantFiled: June 6, 2018Date of Patent: May 17, 2022Assignee: SUMITOMO ELECTRIC SINTERED ALLOY, LTD.Inventors: Hiroaki Motoyama, Takanori Ootaki
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Publication number: 20190263056Abstract: A method for manufacturing a shaped article includes a step of providing a high-speed steel powder, a step of forming a powder layer by spreading the powder, a step of forming a solidified layer in which the powder is in a bound state by irradiating the powder layer with a scanning laser beam, and a step of stacking up solidified layers by sequentially repeating the step of forming a powder layer and the step of forming a solidified layer, thereby forming the shaped article. The laser beam has an energy density of 60 J/mm3 or more and less than 600 J/mm3.Type: ApplicationFiled: June 6, 2018Publication date: August 29, 2019Applicant: SUMITOMO ELECTRIC SINTERED ALLOY, LTD.Inventors: Hiroaki MOTOYAMA, Takanori OOTAKI
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Patent number: 7531333Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: GrantFiled: August 13, 2007Date of Patent: May 12, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Publication number: 20080227141Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: ApplicationFiled: March 11, 2008Publication date: September 18, 2008Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Publication number: 20080131926Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: ApplicationFiled: August 13, 2007Publication date: June 5, 2008Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Koichiro MIYAKE, Shinichi HASHIMOTO, Hiroaki MOTOYAMA, Akio OZAKI, Haruo SETO, Tomohisa KUZUYAMA, Shunji TAKAHASHI
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Patent number: 7364885Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: GrantFiled: April 2, 2007Date of Patent: April 29, 2008Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Publication number: 20070269857Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: ApplicationFiled: April 2, 2007Publication date: November 22, 2007Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Patent number: 7208298Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: GrantFiled: May 24, 2006Date of Patent: April 24, 2007Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Publication number: 20070004000Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: ApplicationFiled: May 24, 2006Publication date: January 4, 2007Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Patent number: 7132268Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: GrantFiled: September 13, 2004Date of Patent: November 7, 2006Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Publication number: 20050032169Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: ApplicationFiled: September 13, 2004Publication date: February 10, 2005Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Patent number: 6806076Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: GrantFiled: October 12, 2000Date of Patent: October 19, 2004Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
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Patent number: 6468780Abstract: Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or CompType: GrantFiled: April 10, 2001Date of Patent: October 22, 2002Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yutaka Takano, Masaru Hasegawa, Hideo Mori, Katsuhiko Ando, Keiko Ochiai, Hiroaki Motoyama, Akio Ozaki
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Publication number: 20010053542Abstract: Disclosed is a process for producing a compound represented by general formula (II-a): 1Type: ApplicationFiled: April 10, 2001Publication date: December 20, 2001Inventors: Yutaka Takano, Masaru Hasegawa, Hideo Mori, katsuhiko Ando, Keiko Ochiai, Hiroaki Motoyama, Akio Ozaki
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Patent number: 6245535Abstract: Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or CompType: GrantFiled: February 2, 2000Date of Patent: June 12, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yutaka Takano, Masaru Hasegawa, Hideo Mori, Katsuhiko Ando, Keiko Ochiai, Hiroaki Motoyama, Akio Ozaki
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Patent number: 5681383Abstract: A surface-treating agent for a high-temperature refractory material, essentially consisting of 35.0 to 50.0 wt % of sodium silicate, 1.0 to 10.0 wt % of lithium compound, 1.0 to 10.0 wt % of alkali borate, 1 to 10.0 wt % of an organic silicone compound represented by the formula, R--Si(OH).sub.2 Na, wherein R stands for an alkyl group of 1 to 12 carbon atoms, and water and having a viscosity of not more than 100 cps at 20.degree. C., and a method for the surface treatment of a high-temperature refractory material, essentially consisting of rapidly spraying the treating agent mentioned above onto the surface of the refractory material when it is at a temperature in the range of 500.degree. to 1200.degree. C., thereby forming a layer of the treating agent in a molten state, and retaining the layer at a temperature of at least 1100.degree. C.Type: GrantFiled: October 5, 1995Date of Patent: October 28, 1997Inventors: Takeshi Andoh, Yasuyuki Yamaguchi, Tadakatu Kisi, Hiroaki Motoyama, Yoshimi Imoto, Matsumi Hirao
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Patent number: 5217883Abstract: Disclosed is a process for producing amino acids such as L-threohine and L-lysine, which comprises culturing, in a medium containing methanol as a major carbon source, a microorganism which belongs to the genus Methylobacillus and which has an ability to produce the amino acid(s) and resistance to at least one member selected from the group consisting of L-threonine, L-lysine and an amino acid analogue, said microorganism being obtained by mutation of a parent strain which belongs to the genus Methylobacillus and which has an enhanced sensitivity to at least one of an antibiotic and an amino acid analogue; allowing the amino acid(s) to accumulate in the culture; and recovering the amino acid(s) therefrom.Type: GrantFiled: August 2, 1991Date of Patent: June 8, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hideharu Anazawa, Hiroaki Motoyama, Sadao Teshiba