Patents by Inventor Hiroaki Nishiuchi
Hiroaki Nishiuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10537128Abstract: A yeast extract containing 0.2% or more of ?-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.Type: GrantFiled: November 16, 2016Date of Patent: January 21, 2020Assignee: AJINOMOTO CO., INC.Inventors: Hiroaki Nishiuchi, Misato Morita, Wataru Hoshino, Junko Yamazaki, Takayuki Ito, Kazuo Yamagishi
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Patent number: 10000760Abstract: Yeast and a yeast extract with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly are provided. By modifying yeast so that intracellular acetolactate synthase activity is reduced, yeast with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly is obtained. An yeast extract is prepared by using the yeast obtained in such a manner as a raw material.Type: GrantFiled: December 21, 2015Date of Patent: June 19, 2018Assignee: AJINOMOTO CO., INC.Inventors: Misato Morita, Hiroaki Nishiuchi
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Publication number: 20170067085Abstract: A yeast extract containing 0.2% or more of ?-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.Type: ApplicationFiled: November 16, 2016Publication date: March 9, 2017Applicant: AJINOMOTO CO., INC.Inventors: Hiroaki NISHIUCHI, Misato MORITA, Wataru HOSHINO, Junko YAMAZAKI, Takayuki ITO, Kazuo YAMAGISHI
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Publication number: 20160177323Abstract: Yeast and a yeast extract with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly are provided. By modifying yeast so that intracellular acetolactate synthase activity is reduced, yeast with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly is obtained. An yeast extract is prepared by using the yeast obtained in such a manner as a raw material.Type: ApplicationFiled: December 21, 2015Publication date: June 23, 2016Applicant: AJINOMOTO CO., INC.Inventors: Misato Morita, Hiroaki Nishiuchi
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Patent number: 9034403Abstract: A yeast extract containing a peptide, such as ?-Glu-X and ?-Glu-X-Gly, wherein X can represent an amino acid or an amino acid derivative other than Cys and derivatives thereof, is prepared by culturing a yeast in a medium containing a peptide such as ?-Glu-X, ?-Glu-X-Gly and X-Gly, and preparing a yeast extract from the obtained cells.Type: GrantFiled: August 24, 2012Date of Patent: May 19, 2015Assignee: AJINOMOTO CO., INC.Inventors: Hiroaki Nishiuchi, Wataru Hoshino, Junko Yamazaki, Toshimi Mizukoshi, Vsevolod Aleksandovich Serebryanyy, Olga Aleksandrovna Sofyanovich, Dmitriy Aleksandrovich Cheshev, V. Elena Matrosova
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Publication number: 20130280381Abstract: A yeast extract containing 0.2% or more of ?-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.Type: ApplicationFiled: March 15, 2013Publication date: October 24, 2013Inventors: Hiroaki Nishiuchi, Misato Morita, Wataru Hoshino, Junko Yamazaki, Takayuki Ito, Kazuo Yamagishi
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Publication number: 20130045305Abstract: A yeast extract containing a peptide, such as ?-Glu-X and ?-Glu-X-Gly, wherein X can represent an amino acid or an amino acid derivative other than Cys and derivatives thereof, is prepared by culturing a yeast in a medium containing a peptide such as ?-Glu-X, ?-Glu-X-Gly and X-Gly, and preparing a yeast extract from the obtained cells.Type: ApplicationFiled: August 24, 2012Publication date: February 21, 2013Applicant: Ajinomoto Co., Inc.Inventors: Hiroaki NISHIUCHI, Wataru Hoshino, Junko Yamazaki, Toshimi Mizukoshi, Vsevolod Aleksandovich Serebryanyy, Olga Aleksandrovna Sofyanovich, Dmitriy Aleksandrovich Cheshev, V. Elena Matrosova
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Patent number: 7569360Abstract: A yeast which harbors a mutant glutathione synthetase having one or both of mutations selected from the group consisting of a mutation to replace a threonine residue at the position 47 with an isoleucine residue and a mutation to replace a glycine residue at the 387-position with an aspartic acid residue and produces ?-glutamylcysteine. The yeast is cultured under suitable conditions, the resultant culture or fractionation product thereof or the resultant culture or fractionation product thereof that had been heat-treated is mixed with food or beverage materials and processed into foods or beverage to produce ?-glutamylcysteine- or cysteine-containing foods or beverage.Type: GrantFiled: May 26, 2004Date of Patent: August 4, 2009Assignee: Ajinomoto Co., Inc.Inventors: Hiroaki Nishiuchi, Reiko Sugimoto
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Patent number: 7553638Abstract: Food containing ?-glutamylcysteine or cysteine is produced by culturing Candida utilis containing 1% by weight or more of ?-glutamylcysteine per dry cells in logarithmic growth phase when cultured in a minimal medium, for example, Candida utilis in which a gene encoding glutathione synthetase is modified so that intracellular glutathione synthetase activity is reduced, under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.Type: GrantFiled: September 27, 2004Date of Patent: June 30, 2009Assignee: Ajinomoto Co., Inc.Inventors: Hiroaki Nishiuchi, Yasushi Nishimura, Motonaka Kuroda
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Publication number: 20090136624Abstract: The present invention provides lactic acid bacteria producing Nisin, a method for selecting the same, and foods or feeds using the lactic acid bacteria.Type: ApplicationFiled: January 26, 2009Publication date: May 28, 2009Applicant: Ajinomoto Co., Inc.Inventors: Naoko TANAKA, Hiroaki NISHIUCHI, Akinori UEHARA, Nobutoshi MATSUMOTO
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Patent number: 7410790Abstract: The yeast which has ?-glutamylcysteine-producing ability and is auxotrophic for pantothenic acid is proliferated in a medium containing a sufficient amount of pantothenic acid, and then it is cultured in a medium containing a limited amount of pantothenic acid to increase the ?-glutamylcysteine content in its cells, whereby the yeast in which ?-glutamylcysteine is accumulated is obtained.Type: GrantFiled: December 11, 2003Date of Patent: August 12, 2008Assignee: Ajinomoto Co., Inc.Inventors: Mariko Suehiro, Hiroaki Nishiuchi, Yasushi Nishimura
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Patent number: 7297513Abstract: A gene encoding glutathione synthetase from Candida utilis is provided and food containing ?-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by means of a gene encoding glutathione synthetase under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.Type: GrantFiled: August 11, 2004Date of Patent: November 20, 2007Assignee: Ajinomoto Co., Inc.Inventors: Hiroaki Nishiuchi, Yasushi Nishimura
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Publication number: 20070020250Abstract: The present invention provides lactic acid bacteria producing Nisin, a method for selecting the same, and foods or feeds using the lactic acid bacteria.Type: ApplicationFiled: August 23, 2006Publication date: January 25, 2007Applicant: Ajinomoto Co., Inc.Inventors: Naoko Tanaka, Hiroaki Nishiuchi, Akinori Uehara, Nobutoshi Matsumoto
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Patent number: 7160570Abstract: The present invention relates to a method for the manufacture of a food material containing high quantities of cysteine. In this method, a yeast extract is prepared from yeast cells that contains ?-glutamylcysteine and the extract is concentrated by controlling the temperature to be not greater than 60° C. to prepare a food material in a liquid form, wherein the concentration of solids is at least 10% and the resulting food material is maintained at 70 to 130° C.Type: GrantFiled: March 10, 2004Date of Patent: January 9, 2007Assignee: Ajinomoto Co., Inc.Inventors: Hiroaki Nishiuchi, Yuki Nishimori, Yasushi Nishimura
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Patent number: 7118775Abstract: The present invention relates to a method for producing a cysteine-rich food material by maintaining a food material containing ?-glutamylcysteine at a ratio of at least 1 wt % to the solid content thereof at a temperature ranging from 50 to 120° C. and at a pH ranging from 1 to 7. This process is conducted in the absence of a sugar and in the presence of water. The present invention also relates to a method for producing a cysteine-rich food material by reacting the food material with a ?-glutamyl peptide hydrolase at a pH ranging from 3 to 9 and at a temperature ranging from 15 to 70° C. in the present of water. Further, the present invention relates to a method for producing a flavor-enhancing material for use in food, food products obtained by these processes, and yeast cells or extracts for use in food products.Type: GrantFiled: December 2, 2002Date of Patent: October 10, 2006Assignee: Ajinomoto Co., Inc.Inventors: Masanori Kohmura, Yasushi Nishimura, Koh-ichiro Sano, Hirokazu Kawaguchi, Gaku Hibino, Reiko Sugimoto, Hiroaki Nishiuchi, Hidehiko Wakabayashi, Yoichi Ueda, Minori Ishiguro, legal representative, Tatsuya Ishiguro, legal representative, Shouji Ishiguro, legal representative, Youhei Ishiguro, legal representative, Kyousuki Ishiguro, deceased
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Publication number: 20050220937Abstract: The present invention relates to a seasoning and a processed food which are obtained by processing a fermented soybean paste-like foodstuff, and a method of the production thereof.Type: ApplicationFiled: March 31, 2005Publication date: October 6, 2005Applicant: Ajinomoto Co., Inc.Inventors: Keiko Ito, Atsuko Kayahara, Gaku Hibino, Yutaka Nishimura, Yasushi Nishimura, Hiroaki Nishiuchi
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Publication number: 20050196836Abstract: A yeast which harbors a mutant glutathione synthetase having one or both of mutations selected from the group consisting of a mutation to replace a threonine residue at the position 47 with an isoleucine residue and a mutation to replace a glycine residue at the 387-position with an aspartic acid residue and produces ?-glutamylcysteine. The yeast is cultured under suitable conditions, the resultant culture or fractionation product thereof or the resultant culture or fractionation product thereof that had been heat-treated is mixed with food or beverage materials and processed into foods or beverage to produce ?-glutamylcysteine- or cysteine-containing foods or beverage.Type: ApplicationFiled: May 26, 2004Publication date: September 8, 2005Applicant: Ajinomoto Co., Inc.Inventors: Hiroaki Nishiuchi, Reiko Sugimoto
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Publication number: 20050074835Abstract: A gene encoding glutathione synthetase from Candida utilis is provided and food containing ?-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by means of a gene encoding glutathione synthetase under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.Type: ApplicationFiled: August 11, 2004Publication date: April 7, 2005Applicant: Ajinomoto Co., Inc.Inventors: Hiroaki Nishiuchi, Yasushi Nishimura
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Publication number: 20050042328Abstract: Food containing ?-glutamylcysteine or cysteine is produced by culturing Candida utilis containing 1% by weight or more of ?-glutamylcysteine per dry cells in logarithmic growth phase when cultured in a minimal medium, for example, Candida utilis in which a gene encoding glutathione synthetase is modified so that intracellular glutathione synthetase activity is reduced, under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.Type: ApplicationFiled: September 27, 2004Publication date: February 24, 2005Applicant: Ajinomoto Co., Inc.Inventors: Hiroaki Nishiuchi, Yasushi Nishimura, Motonaka Kuroda
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Publication number: 20040265471Abstract: The present invention relates to a method for producing a cysteine-rich food material by maintaining a food material containing &ggr;-glutamylcysteine at a ratio of at least 1 wt % to the solid content thereof at a temperature ranging from 50 to 120° C. and at a pH ranging from 1 to 7. This process is conducted in the absence of a sugar and in the presence of water. The present invention also relates to a method for producing a cysteine-rich food material by reacting the food material with a &ggr;-glutamyl peptide hydrolase at a pH ranging from 3 to 9 and at a temperature ranging from 15 to 70° C. in the present of water. Further, the present invention relates to a method for producing a flavor-enhancing material for use in food, food products obtained by these processes, and yeast cells or extracts for use in food products.Type: ApplicationFiled: December 2, 2002Publication date: December 30, 2004Applicant: AJINOMOTO CO. INCInventors: Masanori Kohmura, Yasushi Nishimura, Koh-ichiro Sano, Hirokazu Kawaguchi, Gaku Hibino, Reiko Sugimoto, Hiroaki Nishiuchi, Hidehiko Wakabayashi, Yoichi Ueda, Kyousuke Ishiguro, Minori Ishiguro, Tatsuya Ishiguro, Shouji Ishiguro, Youhei Ishiguro