Patents by Inventor Hiroaki Nishiuchi

Hiroaki Nishiuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10537128
    Abstract: A yeast extract containing 0.2% or more of ?-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: January 21, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Hiroaki Nishiuchi, Misato Morita, Wataru Hoshino, Junko Yamazaki, Takayuki Ito, Kazuo Yamagishi
  • Patent number: 10000760
    Abstract: Yeast and a yeast extract with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly are provided. By modifying yeast so that intracellular acetolactate synthase activity is reduced, yeast with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly is obtained. An yeast extract is prepared by using the yeast obtained in such a manner as a raw material.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: June 19, 2018
    Assignee: AJINOMOTO CO., INC.
    Inventors: Misato Morita, Hiroaki Nishiuchi
  • Publication number: 20170067085
    Abstract: A yeast extract containing 0.2% or more of ?-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.
    Type: Application
    Filed: November 16, 2016
    Publication date: March 9, 2017
    Applicant: AJINOMOTO CO., INC.
    Inventors: Hiroaki NISHIUCHI, Misato MORITA, Wataru HOSHINO, Junko YAMAZAKI, Takayuki ITO, Kazuo YAMAGISHI
  • Publication number: 20160177323
    Abstract: Yeast and a yeast extract with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly are provided. By modifying yeast so that intracellular acetolactate synthase activity is reduced, yeast with a high content of Abu, ?-Glu-Abu, and/or ?-Glu-Abu-Gly is obtained. An yeast extract is prepared by using the yeast obtained in such a manner as a raw material.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 23, 2016
    Applicant: AJINOMOTO CO., INC.
    Inventors: Misato Morita, Hiroaki Nishiuchi
  • Patent number: 9034403
    Abstract: A yeast extract containing a peptide, such as ?-Glu-X and ?-Glu-X-Gly, wherein X can represent an amino acid or an amino acid derivative other than Cys and derivatives thereof, is prepared by culturing a yeast in a medium containing a peptide such as ?-Glu-X, ?-Glu-X-Gly and X-Gly, and preparing a yeast extract from the obtained cells.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: May 19, 2015
    Assignee: AJINOMOTO CO., INC.
    Inventors: Hiroaki Nishiuchi, Wataru Hoshino, Junko Yamazaki, Toshimi Mizukoshi, Vsevolod Aleksandovich Serebryanyy, Olga Aleksandrovna Sofyanovich, Dmitriy Aleksandrovich Cheshev, V. Elena Matrosova
  • Publication number: 20130280381
    Abstract: A yeast extract containing 0.2% or more of ?-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 24, 2013
    Inventors: Hiroaki Nishiuchi, Misato Morita, Wataru Hoshino, Junko Yamazaki, Takayuki Ito, Kazuo Yamagishi
  • Publication number: 20130045305
    Abstract: A yeast extract containing a peptide, such as ?-Glu-X and ?-Glu-X-Gly, wherein X can represent an amino acid or an amino acid derivative other than Cys and derivatives thereof, is prepared by culturing a yeast in a medium containing a peptide such as ?-Glu-X, ?-Glu-X-Gly and X-Gly, and preparing a yeast extract from the obtained cells.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 21, 2013
    Applicant: Ajinomoto Co., Inc.
    Inventors: Hiroaki NISHIUCHI, Wataru Hoshino, Junko Yamazaki, Toshimi Mizukoshi, Vsevolod Aleksandovich Serebryanyy, Olga Aleksandrovna Sofyanovich, Dmitriy Aleksandrovich Cheshev, V. Elena Matrosova
  • Patent number: 7569360
    Abstract: A yeast which harbors a mutant glutathione synthetase having one or both of mutations selected from the group consisting of a mutation to replace a threonine residue at the position 47 with an isoleucine residue and a mutation to replace a glycine residue at the 387-position with an aspartic acid residue and produces ?-glutamylcysteine. The yeast is cultured under suitable conditions, the resultant culture or fractionation product thereof or the resultant culture or fractionation product thereof that had been heat-treated is mixed with food or beverage materials and processed into foods or beverage to produce ?-glutamylcysteine- or cysteine-containing foods or beverage.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: August 4, 2009
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroaki Nishiuchi, Reiko Sugimoto
  • Patent number: 7553638
    Abstract: Food containing ?-glutamylcysteine or cysteine is produced by culturing Candida utilis containing 1% by weight or more of ?-glutamylcysteine per dry cells in logarithmic growth phase when cultured in a minimal medium, for example, Candida utilis in which a gene encoding glutathione synthetase is modified so that intracellular glutathione synthetase activity is reduced, under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: June 30, 2009
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroaki Nishiuchi, Yasushi Nishimura, Motonaka Kuroda
  • Publication number: 20090136624
    Abstract: The present invention provides lactic acid bacteria producing Nisin, a method for selecting the same, and foods or feeds using the lactic acid bacteria.
    Type: Application
    Filed: January 26, 2009
    Publication date: May 28, 2009
    Applicant: Ajinomoto Co., Inc.
    Inventors: Naoko TANAKA, Hiroaki NISHIUCHI, Akinori UEHARA, Nobutoshi MATSUMOTO
  • Patent number: 7410790
    Abstract: The yeast which has ?-glutamylcysteine-producing ability and is auxotrophic for pantothenic acid is proliferated in a medium containing a sufficient amount of pantothenic acid, and then it is cultured in a medium containing a limited amount of pantothenic acid to increase the ?-glutamylcysteine content in its cells, whereby the yeast in which ?-glutamylcysteine is accumulated is obtained.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: August 12, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mariko Suehiro, Hiroaki Nishiuchi, Yasushi Nishimura
  • Patent number: 7297513
    Abstract: A gene encoding glutathione synthetase from Candida utilis is provided and food containing ?-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by means of a gene encoding glutathione synthetase under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: November 20, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroaki Nishiuchi, Yasushi Nishimura
  • Publication number: 20070020250
    Abstract: The present invention provides lactic acid bacteria producing Nisin, a method for selecting the same, and foods or feeds using the lactic acid bacteria.
    Type: Application
    Filed: August 23, 2006
    Publication date: January 25, 2007
    Applicant: Ajinomoto Co., Inc.
    Inventors: Naoko Tanaka, Hiroaki Nishiuchi, Akinori Uehara, Nobutoshi Matsumoto
  • Patent number: 7160570
    Abstract: The present invention relates to a method for the manufacture of a food material containing high quantities of cysteine. In this method, a yeast extract is prepared from yeast cells that contains ?-glutamylcysteine and the extract is concentrated by controlling the temperature to be not greater than 60° C. to prepare a food material in a liquid form, wherein the concentration of solids is at least 10% and the resulting food material is maintained at 70 to 130° C.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: January 9, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroaki Nishiuchi, Yuki Nishimori, Yasushi Nishimura
  • Patent number: 7118775
    Abstract: The present invention relates to a method for producing a cysteine-rich food material by maintaining a food material containing ?-glutamylcysteine at a ratio of at least 1 wt % to the solid content thereof at a temperature ranging from 50 to 120° C. and at a pH ranging from 1 to 7. This process is conducted in the absence of a sugar and in the presence of water. The present invention also relates to a method for producing a cysteine-rich food material by reacting the food material with a ?-glutamyl peptide hydrolase at a pH ranging from 3 to 9 and at a temperature ranging from 15 to 70° C. in the present of water. Further, the present invention relates to a method for producing a flavor-enhancing material for use in food, food products obtained by these processes, and yeast cells or extracts for use in food products.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: October 10, 2006
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masanori Kohmura, Yasushi Nishimura, Koh-ichiro Sano, Hirokazu Kawaguchi, Gaku Hibino, Reiko Sugimoto, Hiroaki Nishiuchi, Hidehiko Wakabayashi, Yoichi Ueda, Minori Ishiguro, legal representative, Tatsuya Ishiguro, legal representative, Shouji Ishiguro, legal representative, Youhei Ishiguro, legal representative, Kyousuki Ishiguro, deceased
  • Publication number: 20050220937
    Abstract: The present invention relates to a seasoning and a processed food which are obtained by processing a fermented soybean paste-like foodstuff, and a method of the production thereof.
    Type: Application
    Filed: March 31, 2005
    Publication date: October 6, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Keiko Ito, Atsuko Kayahara, Gaku Hibino, Yutaka Nishimura, Yasushi Nishimura, Hiroaki Nishiuchi
  • Publication number: 20050196836
    Abstract: A yeast which harbors a mutant glutathione synthetase having one or both of mutations selected from the group consisting of a mutation to replace a threonine residue at the position 47 with an isoleucine residue and a mutation to replace a glycine residue at the 387-position with an aspartic acid residue and produces ?-glutamylcysteine. The yeast is cultured under suitable conditions, the resultant culture or fractionation product thereof or the resultant culture or fractionation product thereof that had been heat-treated is mixed with food or beverage materials and processed into foods or beverage to produce ?-glutamylcysteine- or cysteine-containing foods or beverage.
    Type: Application
    Filed: May 26, 2004
    Publication date: September 8, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Hiroaki Nishiuchi, Reiko Sugimoto
  • Publication number: 20050074835
    Abstract: A gene encoding glutathione synthetase from Candida utilis is provided and food containing ?-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by means of a gene encoding glutathione synthetase under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.
    Type: Application
    Filed: August 11, 2004
    Publication date: April 7, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Hiroaki Nishiuchi, Yasushi Nishimura
  • Publication number: 20050042328
    Abstract: Food containing ?-glutamylcysteine or cysteine is produced by culturing Candida utilis containing 1% by weight or more of ?-glutamylcysteine per dry cells in logarithmic growth phase when cultured in a minimal medium, for example, Candida utilis in which a gene encoding glutathione synthetase is modified so that intracellular glutathione synthetase activity is reduced, under a suitable condition and mixing the obtained culture or a fraction thereof or the culture or a fraction thereof subjected to heat treatment with a raw material of food or drink to process food or drink.
    Type: Application
    Filed: September 27, 2004
    Publication date: February 24, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Hiroaki Nishiuchi, Yasushi Nishimura, Motonaka Kuroda
  • Publication number: 20040265471
    Abstract: The present invention relates to a method for producing a cysteine-rich food material by maintaining a food material containing &ggr;-glutamylcysteine at a ratio of at least 1 wt % to the solid content thereof at a temperature ranging from 50 to 120° C. and at a pH ranging from 1 to 7. This process is conducted in the absence of a sugar and in the presence of water. The present invention also relates to a method for producing a cysteine-rich food material by reacting the food material with a &ggr;-glutamyl peptide hydrolase at a pH ranging from 3 to 9 and at a temperature ranging from 15 to 70° C. in the present of water. Further, the present invention relates to a method for producing a flavor-enhancing material for use in food, food products obtained by these processes, and yeast cells or extracts for use in food products.
    Type: Application
    Filed: December 2, 2002
    Publication date: December 30, 2004
    Applicant: AJINOMOTO CO. INC
    Inventors: Masanori Kohmura, Yasushi Nishimura, Koh-ichiro Sano, Hirokazu Kawaguchi, Gaku Hibino, Reiko Sugimoto, Hiroaki Nishiuchi, Hidehiko Wakabayashi, Yoichi Ueda, Kyousuke Ishiguro, Minori Ishiguro, Tatsuya Ishiguro, Shouji Ishiguro, Youhei Ishiguro