Abstract: The electrophotographic electroconductive member includes a support having an electroconductive outer surface, and an electroconductive layer on the surface of the support. The electroconductive layer has a matrix containing a crosslinked product of a first rubber, and domains dispersed in the matrix, and the domains each contain a crosslinked product of a second rubber and electroconductive particles. The matrix has a volume resistivity R1 of more than 1.0×1012 ?·cm, and the domains each have a volume resistivity R2 lower than the volume resistivity R1 of the matrix. The electroconductive layer further has a pore, and an inner wall of the pore is constituted by a part of the matrix and a part of the domains. The domains constituting the inner wall protrude into the pore at sites on the inner wall.

Abstract: An electro-conductive member for an electrophotographic image forming apparatus for which a change in resistance value is small even when a large current is applied at a high voltage for a long period of time is provided. The electro-conductive member includes a support having an electro-conductive outer surface and an electro-conductive layer on the outer surface of the support, in which the electro-conductive layer has a matrix including a cross-linked product of a first rubber and domains dispersed in the matrix, the domains include a cross-linked product of a second rubber different from the first rubber and an electrically conductive agent, and the cross-linked product of the second rubber has, in a molecule, a structural unit represented by Structural Formula (I). [—(CH2)n—O—]??Structural Formula (I) In Structural Formula (I), n is an integer of 1 to 3.

Abstract: A roller for electrophotography that has a low electric resistance value and that is still further reduced in contaminating property of other member is provided. The roller includes an electro-conductive mandrel and a surface layer having an electro-conductive foam. The electro-conductive foam includes a vulcanized product of an unvulcanized rubber composition including an acrylonitrile-butadiene rubber and a hydrin rubber. The vulcanized product has a matrix-domain structure having a sea phase and an island phase, contains ethylene oxide of 8.0% by mass or more and 20.0% by mass or less based on a total amount of the vulcanized product, and has a spin-spin relaxation time T2 of 750 ?s<T2<930 ?s.

Abstract: A roller for electrophotography that has a low electric resistance value and that is still further reduced in contaminating property of other member is provided. The roller includes an electro-conductive mandrel and a surface layer having an electro-conductive foam. The electro-conductive foam includes a vulcanized product of an unvulcanized rubber composition including an acrylonitrile-butadiene rubber and a hydrin rubber. The vulcanized product has a matrix-domain structure having a sea phase and an island phase, contains ethylene oxide of 8.0% by mass or more and 20.0% by mass or less based on a total amount of the vulcanized product, and has a spin-spin relaxation time T2 of 750 ?s<T2<930 ?s.

Abstract: A roller for electrophotography that has a low electric resistance value and that is still further reduced in contaminating property of other member is provided. The roller includes an electro-conductive mandrel and a surface layer having an electro-conductive foam. The electro-conductive foam includes a vulcanized product of an unvulcanized rubber composition including an acrylonitrile-butadiene rubber and a hydrin rubber. The vulcanized product has a matrix-domain structure having a sea phase and an island phase, contains ethylene oxide of 8.0% by mass or more and 20.0% by mass or less based on a total amount of the vulcanized product, and has a spin-spin relaxation time T2 of 750 ?s<T2<930 ?s.

Abstract: A compound having an URAT1 inhibitory activity, and an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.

Abstract: A compound having an URAT1 inhibitory activity, and an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.

Abstract: The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.

Abstract: A roller for electrophotography that has a low electric resistance value and that is still further reduced in contaminating property of other member is provided. The roller includes an electro-conductive mandrel and a surface layer having an electro-conductive foam. The electro-conductive foam includes a vulcanized product of an unvulcanized rubber composition including an acrylonitrile-butadiene rubber and a hydrin rubber. The vulcanized product has a matrix-domain structure having a sea phase and an island phase, contains ethylene oxide of 8.0% by mass or more and 20.0% by mass or less based on a total amount of the vulcanized product, and has a spin-spin relaxation time T2 of 750 ?s<T2<930 ?s.

Abstract: The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below.

Abstract: The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below.

Abstract: The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.

Abstract: The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below.

Abstract: The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below.

Abstract: Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.

Abstract: A contact charging roller includes a support member and a conductive coating member. The conductive coating member is composed of a seamless tube that contains at least (1) a non-polar resin or a styrene-type thermoplastic elastomer excluding a poly(styrene-hydrogentaged butadiene-styrene) block terpolymer and (2) a polar resin or an elastomer having a polar functional group containing at least nitrogen or oxygen, and contains carbon black in an amount of 10% to 60% by mass with respect to the total mass of the non-polar resin or elastomer and the polar resin or elastomer.

Abstract: Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.

Abstract: Charging roller has at least a support member and a conductive covering member, the charging roller where a value of tan ? expressed in a ratio of a storage elastic modulus and a loss elastic modulus by dynamic viscoelasticity in a cross sectional direction of the charging roller at 25° C. is 0.2 or more in a range of 1 to 20 kHz and 0.2 or less in a range of 1 to 10 Hz, or a charging roller where the conductive covering member is constructed of two or more layers and a value of tan ? in at least one layer other than a surface layer is 0.2 or more at 10 Hz in a range of 10 to 50° C. and a value of tan ? in a cross sectional direction of the whole charging roller is 0.2 or less at 10 Hz in a range of 10 to 50° C.

Abstract: In a conductive roller having a conductive substrate, a conductive elastic layer and a conductive cover layer, the conductive cover layer is formed of a seamless tube containing a thermoplastic polymer, the surface of the conductive roller is coated with an inorganic compound the particle surfaces of which have been subjected to hydrophobic treatment, and the roller having been coated therewith has a glossiness of from 7.5% or more to less than 22.0%. This conductive roller can make toner and external additives less adhere to the roller surface, can prevent the faulty images due to the adhesion of photosensitive-member abrasion dust and can well perform charging in the image reproduction from the initial stage to the last.

Abstract: A charging roller for a contact charging assembly is provided including a conductive substrate, an elastic layer which covers the periphery of the conductive substrate, and a seamless tube externally so fitted as to cover the periphery of the elastic layer. The seamless tube constitutes a surface layer of the charging roller, and the charging roller has a surface of 3.0 ?m or less in ten-point average roughness (Rz jis 94) and 0.10 mm or less in roughness curve average length (RSm).