Abstract: An OCT device includes a controller configured to: acquire OCT data of a tissue of a subject in a depth direction that is generated by processing interference signal detected by a light receiving element; and perform a correction process to reduce an effect by a noise floor in the OCT data using a plurality of correction amounts each of which is set in accordance with depth at a corresponding data acquisition position. Strength of the noise floor varies depending on the depth of the data acquisition position.

Abstract: The impeller of a rotating machine according to at least one embodiment of the present discloser is provided with: a disc; a cover disposed on an opposite side of a radial passage from the disc in an axial direction; and a blade disposed between the disc and the cover. In a dimensionless position along a camber line of the blade when the position of a leading edge of the blade is defined as 0 and the position of a trailing edge of the blade is defined as 1, a position where an angle difference between a first blade angle at a disc-side end portion of the blade and a second blade angle at a cover-side end portion of the blade is maximum is in a range of 0.5 or more and 1 or less. The first blade angle is ?10 degrees or more and 0 degrees or less at the position where the angle difference is maximum.

Abstract: A centrifugal compressor includes an impeller, a return channel including a return vane for guiding a main stream of a fluid to be compressed by the impeller from an outer side of a main shaft of the impeller in a radial direction toward an inner side, stages of compressor units connected to a downstream side of the return channel and including a first bent channel for changing the main stream to a direction along the main shaft, and an intermediate suction channel connected to the return channel in at least one of the compressor units to merge a suctioned fluid to the main stream. The intermediate suction channel includes a chamber having a scroll shape and passing the suctioned fluid therethrough, and an inlet guide vane for guiding the suctioned fluid. The inlet guide vane is integrated with the return vane in the connected return channel.

Abstract: The impeller of a rotating machine according to at least one embodiment of the present discloser is provided with: a disc; a cover disposed on an opposite side of a radial passage from the disc in an axial direction; and a blade disposed between the disc and the cover. In a dimensionless position along a camber line of the blade when the position of a leading edge of the blade is defined as 0 and the position of a trailing edge of the blade is defined as 1, a position where an angle difference between a first blade angle at a disc-side end portion of the blade and a second blade angle at a cover-side end portion of the blade is maximum is in a range of 0.5 or more and 1 or less. The first blade angle is ?10 degrees or more and 0 degrees or less at the position where the angle difference is maximum.

Abstract: Provided is a humanized antibody that, through IGF-I receptor, increases muscle mass but does not lower the blood glucose level. This humanized antibody: is an anti-IGF-I receptor humanized antibody, a fragment thereof, or a derivative thereof; has a specific amino acid sequence such as SEQ ID NOs: 1 to 6 serving as a CDR sequence; and specifically binds to IGF-I receptor extracellular domain.

Abstract: A suction-and-discharge flow path includes a circumferential flow path that extends in an arc shape about an axis and an external communication path that is connected to both ends of the circumferential flow path. The circumferential flow path has a uniform flow path cross-sectional area in a circumferential direction, and a convex curved surface having a convex curved surface shape is provided between an outer peripheral wall surface of the circumferential flow path and a second inner wall surface of the external communication path. In a case where, when viewed in the axis direction, a curvature radius of the convex curved surface is defined as R and a radial dimension of the circumferential flow path is defined as W, a relationship of W?R?3W is established.

Abstract: A silencing device includes: a flow path forming plate having a flow path forming surface for forming a wall surface of a flow path through which fluid flows; and a cavity defining portion for defining a cavity on the reverse surface side of the flow path forming plate, the reverse surface being located on the reverse side of the flow path forming surface. The flow path forming plate has formed therein a plurality of fine through-holes which are configured to provide communication between the flow path forming surface and the reverse surface and which has a diameter from 0.01 mm to 0.5 mm.

Abstract: The present invention provides a centrifugal compressor (1) including: a first casing (19); a second casing (20) which is disposed on a downstream side of the first casing (19) and has an outer diameter larger than an outer diameter of the first casing; a first impeller (3a) which is disposed on a radially inner side of the first casing; a first return flow path (29a) which is disposed on a radially inner side of the first casing; a second impeller (3b) which is disposed on a radially inner side of the second casing and connected to a downstream side of the first return flow path (29a); an intermediate suction flow path (10) which is disposed on the radially inner side of the second casing and additionally supplies the fluid to a flow path between the first return flow path (29a) and the second impeller (3b); and a second return flow path (29b) which is disposed on the radially inner side of the second casing (20), wherein an outer diameter of the intermediate suction flow path (10) and an outer diameter of t

Abstract: A multi-stage centrifugal compressor includes: a rotor including a plurality of impellers disposed in a plurality of stages in an axial direction; a plurality of diaphragms each including a guide flow path that guides a fluid discharged radially outward from one of the impellers to an adjacent impeller on the following stage, and a communication hole extended from a bottom portion of the guide flow path; a casing that accommodates the plurality of diaphragms therein; and an axial flow path that connects the plurality of communication holes to each other. The casing includes a drain flow path disposed only between the communication hole that is the closest to a suction nozzle and the communication hole that is the closest to an ejection nozzle.

Abstract: The present invention provides a centrifugal compressor (1) including: a first casing (19); a second casing (20) which is disposed on a downstream side of the first casing (19) and has an outer diameter larger than an outer diameter of the first casing; a first impeller (3a) which is disposed on a radially inner side of the first casing; a first return flow path (29a) which is disposed on a radially inner side of the first casing; a second impeller (3b) which is disposed on a radially inner side of the second casing and connected to a downstream side of the first return flow path (29a); an intermediate suction flow path (10) which is disposed on the radially inner side of the second casing and additionally supplies the fluid to a flow path between the first return flow path (29a) and the second impeller (3b); and a second return flow path (29b) which is disposed on the radially inner side of the second casing (20), wherein an outer diameter of the intermediate suction flow path (10) and an outer diameter of t

Abstract: A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.

Abstract: A silencing device includes: a flow path forming plate having a flow path forming surface for forming a wall surface of a flow path through which fluid flows; and a cavity defining portion for defining a cavity on the reverse surface side of the flow path forming plate, the reverse surface being located on the reverse side of the flow path forming surface. The flow path forming plate has formed therein a plurality of fine through-holes which are configured to provide communication between the flow path forming surface and the reverse surface and which has a diameter from 0.01 mm to 0.5 mm.

Abstract: A suction-and-discharge flow path includes a circumferential flow path that extends in an arc shape about an axis and an external communication path that is connected to both ends of the circumferential flow path. The circumferential flow path has a uniform flow path cross-sectional area in a circumferential direction, and a convex curved surface having a convex curved surface shape is provided between an outer peripheral wall surface of the circumferential flow path and a second inner wall surface of the external communication path. In a case where, when viewed in the axis direction, a curvature radius of the convex curved surface is defined as R and a radial dimension of the circumferential flow path is defined as W, a relationship of W?R?3W is established.

Abstract: A centrifugal compressor includes an impeller, a return channel including a return vane for guiding a main stream of a fluid to be compressed by the impeller from an outer side of a main shaft of the impeller in a radial direction toward an inner side, stages of compressor units connected to a downstream side of the return channel and including a first bent channel for changing the main stream to a direction along the main shaft, and an intermediate suction channel connected to the return channel in at least one of the compressor units to merge a suctioned fluid to the main stream. The intermediate suction channel includes a chamber having a scroll shape and passing the suctioned fluid therethrough, and an inlet guide vane for guiding the suctioned fluid. The inlet guide vane is integrated with the return vane in the connected return channel.

Abstract: Provided is a robot and a control method thereof in which the motion of an arm 12 as a specified limb among a plurality of limbs 12 and 14 extended from a body 10 is controlled according to a specified trajectory. If a first interaction state, in which a hand 126, which is an end effector, interacts with a horizontal wood member L (j) of a ladder L in a first mode is implemented, then a control command is given to an actuator 41 that drives the hand 126 to cause the hand 126 to perform a grasping motion, thereby implementing a second interaction state, in which the hand 126 interacts with the horizontal wood member L (j) in a second manner. If the second interaction state is implemented, a control command is given to a brake 42 to maintain a motion halt state of the hand 126.

Abstract: A multi-stage centrifugal compressor includes: a rotor including a plurality of impellers disposed in a plurality of stages in an axial direction; a plurality of diaphragms each including a guide flow path that guides a fluid discharged radially outward from one of the impellers to an adjacent impeller on the following stage, and a communication hole extended from a bottom portion of the guide flow path; a casing that accommodates the plurality of diaphragms therein; and an axial flow path that connects the plurality of communication holes to each other. The casing includes a drain flow path disposed only between the communication hole that is the closest to a suction nozzle and the communication hole that is the closest to an ejection nozzle.

Abstract: Provide is a robot and a control method thereof in which the motion of an arm 12 as a specified limb among a plurality of limbs 12 and 14 extended from a body 10 is controlled according to a specified trajectory. If a first interaction state, in which a hand 126, which is an end effector, interacts with a horizontal wood member L (j) of a ladder L in a first mode is implemented, then a control command is given to an actuator 41 that drives the hand 126 to cause the hand 126 to perform a grasping motion, thereby implementing a second interaction state, in which the hand 126 interacts with the horizontal wood member L (j) in a second manner. If the second interaction state is implemented, a control command is given to a brake 42 to maintain a motion halt state of the hand 126.

Abstract: A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.

Abstract: An ultrasonic sensor device includes a substrate, a piezoelectric vibrator, and a Q-factor adjuster. The piezoelectric vibrator includes a pair of detection electrodes that face each other in a thickness direction of the substrate and a piezoelectric body interposed between the electrodes. The piezoelectric vibrator provides a membrane structure which is formed on a surface of the substrate and has rigidity lower than that of a remaining portion of the substrate. An ultrasonic wave is transmitted by the piezoelectric vibrator, and its reflected wave is received by the same piezoelectric vibrator. The Q-factor adjuster adjusts a Q-factor of the piezoelectric vibrator so that the Q-factor can be larger during a transmission period where the piezoelectric vibrator transmits the ultrasonic wave than during a reception period where the piezoelectric vibrator receives the ultrasonic wave.

Abstract: A complex device includes: a substrate having a thick portion, a cavity and a membrane for bridging the cavity; and multiple piezoelectric elements having a lower electrode, a piezoelectric film and an upper electrode. A part of the piezoelectric elements has a projecting portion arranged on the upper electrode. The part of piezoelectric elements (30) provides a vertical pressure detection element. The piezoelectric elements further have an ultrasonic element other than the vertical pressure detection element. The ultrasonic element is arranged over at least the cavity of the substrate in a horizontal direction.