Patents by Inventor Hiroharu Kawahara

Hiroharu Kawahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190153498
    Abstract: The present invention provides a production method of a protein including suspension culture of a cell having protein production ability in a medium composition containing nanofiber under physical disruption conditions and in a state of being attached to the nanofiber.
    Type: Application
    Filed: April 4, 2017
    Publication date: May 23, 2019
    Applicants: NISSAN CHEMICAL CORPORATION, NATIONAL INSTITUTE OF TECHNOLOGY, JAPAN
    Inventors: Tatsuro KANAKI, Hisato HAYASHI, Hiroharu KAWAHARA
  • Patent number: 10017805
    Abstract: The present invention relates to a protein production accelerating agent that has enabled to largely increase the produced amount of a desired protein by adding polysaccharides to a medium for animal cells containing a serum or serum alternative, and a production method of a protein using a medium containing the protein production accelerating agent.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: July 10, 2018
    Assignees: Nissan Chemical Industries, Ltd., Institute of National Colleges of Tehcnology, Japan
    Inventors: Misayo Tomura, Takehisa Iwama, Koichiro Saruhashi, Taito Nishino, Masato Horikawa, Hiroharu Kawahara
  • Patent number: 9511124
    Abstract: This invention provides an anti-allergic substance that effectively inhibits allergic symptoms by inhibiting production of the IgE antibody associated with the development of allergies. Anti-allergic substances, pharmaceutical products (i.e., anti-allergic agents), and food (i.e., food with health-promoting benefits) containing strawberry-derived glyceraldehyde-3-phosphate do not cause side effects such as those caused by steroids, and such substances can be consumed through daily meals and can alleviate allergic symptoms.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: December 6, 2016
    Assignee: Institute of National Colleges of Technology, Japan
    Inventors: Hiroharu Kawahara, Yuichi Inoue
  • Publication number: 20140162318
    Abstract: [Summary] The present invention relates to a protein production accelerating agent that has enabled to largely increase the produced amount of a desired protein by adding polysaccharides to a medium for animal cells containing a serum or serum alternative, and a production method of a protein using a medium containing the protein production accelerating agent.
    Type: Application
    Filed: August 23, 2013
    Publication date: June 12, 2014
    Applicants: Institute of National Colleges of Technology, Japan, Nissan Chemical Industries, Ltd.
    Inventors: Misayo TOMURA, Takehisa IWAMA, Koichiro SARUHASHI, Taito NISHINO, Masato HORIKAWA, Hiroharu KAWAHARA
  • Publication number: 20140037690
    Abstract: This invention provides an anti-allergic substance that effectively inhibits allergic symptoms by inhibiting production of the IgE antibody associated with the development of allergies. Anti-allergic substances, pharmaceutical products (i.e., anti-allergic agents), and food (i.e., food with health-promoting benefits) containing strawberry-derived glyceraldehyde-3-phosphate do not cause side effects such as those caused by steroids, and such substances can be consumed through daily meals and can alleviate allergic symptoms.
    Type: Application
    Filed: April 17, 2012
    Publication date: February 6, 2014
    Inventors: Hiroharu Kawahara, Yuichi Inque
  • Patent number: 7678570
    Abstract: A novel human cell strain enabling the continuous production of a desired protein with high efficiency, comprising a novel human cell strain established by transforming a human cell strain whose total intracellular protein weight is 0.1 to 1 mg per 1,000,000 cells; with the novel human cell strain being further characterized in that after a gene encoding a desired protein is transfected into it, the transfected cell is subsequently cultured.
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: March 16, 2010
    Assignee: Kitakyushu Foundation for the Advancement of Industry, Science and Technology
    Inventor: Hiroharu Kawahara
  • Publication number: 20070196896
    Abstract: A novel human cell strain enabling the continuous production of a desired protein with high efficiency, comprising a novel human cell strain established by transforming a human cell strain whose total intracellular protein weight is 0.1 to 1 mg 1,000,000 cells; with the novel human cell strain being further characterized in that after a gene encoding a desired protein is transfected into it, the transfected cell is subsequently cultured.
    Type: Application
    Filed: October 27, 2004
    Publication date: August 23, 2007
    Inventor: Hiroharu Kawahara
  • Patent number: 6013518
    Abstract: Provided are a human immunocompetent fused cell line, characterized in that any one of a mutant cell selected from the group consisting of ICLU-B, ICLU-T and ICLU-E is used as a parent cell line, wherein said mutant cell is obtained by selecting an 8-azaguanine- or 6-thioguanine-resistant clone from a human Burkitt lymphoma cell line Raji, a human T-cell lymphocytic leukemia cell line PEER and a human eosinophilic leukemia cell line EoL-1, and then treating said clone in order to capable of serum-free culture, and a method of obtaining said human immunocompetent fused cell line.The human immunocoipetent fused cell line obtained by the present invention is used to investigate food functions, novel drugs and production thereof with the view to the elucidation of mechanisms of phenomena of an immune system such as allergies, cancers and the like using human cell lines, and the prevention, diagnosis and therapy of these diseases.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: January 11, 2000
    Assignees: Director-General of National Research Institute of Vegetables, Ornamental Plants and Tea, Ministry of Agriculture, Forestry and Fisheries, Bio-oriented Technology Research Advancement Institution
    Inventors: Kenkou Tsuji, Mari Yamamoto, Kazuhiro Osada, Hiroharu Kawahara
  • Patent number: 5739540
    Abstract: A nuclear medicine diagnostic apparatus, particularly involving emission computed tomography, wherein absorption correction is performed by a gamma ray source including a plurality of line sources arrayed in a common plane. Each line source produces a radiation distribution having a peak and defining a half-width distance at which the radiation from the line source is attenuated by one-half. The plurality of line sources are arranged at a pitch equal to the half-width distance or an integral multiple of the half-width distance. In one embodiment, a serpentine line source is used having straight line portions and a plurality of bent portions, with the straight line portions arrayed parallel to each other at a pitch equal to the half-width distance or an integral multiple of the half-width distance.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: April 14, 1998
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Nobutoku Motomura, Takashi Ichihara, Hiroharu Kawahara