Patents by Inventor Hirohiko Yamauchi
Hirohiko Yamauchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5667762Abstract: There is disclosed an agent for preventing the adhesion of thallium 201 to a container which comprises a reducing substance as an active ingredient. There is also disclosed a radioactive diagnostic agent wherein the adhesion of thallium 201 to a container is prevented which comprises thallium 201 and a reducing substance.Type: GrantFiled: April 10, 1996Date of Patent: September 16, 1997Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Makoto Fukushima, Kazuhiro Kimura, Hirohiko Yamauchi, Kenichi Morishita, Keietsu Takahashi
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Patent number: 5274082Abstract: A chelating compound of the formula:(R--NHOC--CH.sub.2).sub.n --A--(CH.sub.2 COOH).sub.m (I)wherein R is an aromatic ring-containing organic group, A is a residue of an aminopolyacetic acid excluding acetic acid groups (--CH.sub.2 COOH) therefrom, m is an integer of at least two and n is an integer of 1 or 2, or its salt, which has a specificity to a hepatobiliary system so that a complex formed between said chelating compound and a metallic element through a coordinate bond is useful as a diagnostic or therapeutic agent for hepatobiliary organs and tissues.Type: GrantFiled: February 25, 1992Date of Patent: December 28, 1993Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Shigemi Seri, Hirohiko Yamauchi, Makoto Azuma, Yoji Arata
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Patent number: 5196576Abstract: A chelating compound of the formula:(R-NHOC-CH.sub.2).sub.n --A--(CH.sub.2 COOH).sub.m (I)wherein R is an aromatic ring-containing organic group, A is a residue of an aminopolyacetic acid excluding acetic acid groups (--CH.sub.2 COOH) therefrom, m is an integer of at least two and n is an integer of 1 or 2, or its salt, which has a specificity to a hepatobiliary system so that a complex formed between said chelating compound and a metallic element through a covalent bond is useful as a diagnostic or therapeutic agent for hepatobiliary organs and tissues.Type: GrantFiled: April 9, 1991Date of Patent: March 23, 1993Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Shigemi Seri, Hirohiko Yamauchi, Makoto Azuma, Yoji Arata
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Patent number: 5138039Abstract: A chelating compound of the formula:(R--NHOC--CH.sub.2).sub.n --A--(CH.sub.2 COOH).sub.m (I)wherein R is an aromatic ring-containing organic group, A is a residue of an aminopolyacetic acid excluding acetic acid groups (--CH.sub.2 COOH) therefrom, m is an integer of at least two and n is an integer of 1 or 2, or its salt, which has a specificity to a hepatobiliary system so that a complex formed between said chelating compound and a metallic element through a coordinate bond is useful and a diagnostic or therapeutic agent for hepatobiliary organs and tissues.Type: GrantFiled: August 15, 1991Date of Patent: August 11, 1992Assignee: Nihon Medi-Physics Co., LtdInventors: Shigemi Seri, Hirohiko Yamauchi, Makoto Azuma, Yoji Arata
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Patent number: 5096693Abstract: A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.Type: GrantFiled: February 15, 1991Date of Patent: March 17, 1992Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Makoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
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Patent number: 5071636Abstract: A polyaminedithiol compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.11 and R.sub.12 are each a lower alkyl group, R.sub.21 is a hydrogen atom or a lower alkyl group, and R.sub.3 and R.sub.13 are each a hydrogen atom or a nitrogen-containing organic group, provided that at least one of R.sub.3 and R.sub.13 is a nitrogen-containing organic group, which is used for imaging of the regional cerebral blood flow.Type: GrantFiled: December 28, 1988Date of Patent: December 10, 1991Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Hirohiko Yamauchi, Jun Takahashi, Sakae Okano, Shigemi Seri, Makoto Azuma
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Patent number: 5015462Abstract: A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.Type: GrantFiled: June 8, 1989Date of Patent: May 14, 1991Assignee: Nihon Medi-Physics Co. Ltd.Inventors: Makoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
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Patent number: 4996312Abstract: A porphyrin compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each --CH.dbd.CH.sub.2, --CH.sub.2 CHJ.sub.3, --CH(O-lower alkanoyl)CH.sub.3, --CH(OR)CH.sub.3 or --CH(O-lower alkylene-OR)CH.sub.3 ; R.sub.3 is --H, --COOH, --COO-lower alkyl, --COO-lower alkylene-OR or --COO-lower alkylene-OOC-Z; R.sub.4 is --H, -lower alkyl or -lower alkylene-OR; R is --H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R.sub.3 therefrom; A is --CH.sub.2 -- or --CO--; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfunctional carboxyl compound, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.Type: GrantFiled: April 19, 1989Date of Patent: February 26, 1991Assignees: Nihon Medi-Physics Co., Ltd., Toyo Hakka Kogyo Co., Ltd.Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata, Hirohiko Yamauchi, Nobuo Ueda, Masaaki Hazue
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Patent number: 4880616Abstract: A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.Type: GrantFiled: December 17, 1987Date of Patent: November 14, 1989Assignee: Nihon Medi-Physics Co., LtdInventors: Makoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
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Patent number: 4849207Abstract: A porphyrin compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each --CH.dbd.CH.sub.2, --CH.sub.2 CH.sub.3, --CH(O-lower alkanoyl)CH.sub.3, --CH(OR)CH.sub.3 or --CH(O-lower alkylene-OR)CH.sub.3 ; R.sub.3 is --H, --COOH, --COO-lower alkyl, --COO-lower alkylene-OR or --COO-lower alkylene-OOC-Z; R.sub.4 is --H, -lower alkyl or -lower alkylene-OR; R is --H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R.sub.3 therefrom; A is --CH.sub.2 -- or --CO--; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfuntional carboxyl compound, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.Type: GrantFiled: October 23, 1986Date of Patent: July 18, 1989Assignees: Nihon Medi-Physics Co., Ltd., Toyo Hakka Kogyo Co., Ltd.Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata, Hirohiko Yamauchi, Nobuo Ueda, Masaaki Hazue