Patents by Inventor Hirohiko Yamauchi

Hirohiko Yamauchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5667762
    Abstract: There is disclosed an agent for preventing the adhesion of thallium 201 to a container which comprises a reducing substance as an active ingredient. There is also disclosed a radioactive diagnostic agent wherein the adhesion of thallium 201 to a container is prevented which comprises thallium 201 and a reducing substance.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: September 16, 1997
    Assignee: Nihon Medi-Physics Co., Ltd.
    Inventors: Makoto Fukushima, Kazuhiro Kimura, Hirohiko Yamauchi, Kenichi Morishita, Keietsu Takahashi
  • Patent number: 5274082
    Abstract: A chelating compound of the formula:(R--NHOC--CH.sub.2).sub.n --A--(CH.sub.2 COOH).sub.m (I)wherein R is an aromatic ring-containing organic group, A is a residue of an aminopolyacetic acid excluding acetic acid groups (--CH.sub.2 COOH) therefrom, m is an integer of at least two and n is an integer of 1 or 2, or its salt, which has a specificity to a hepatobiliary system so that a complex formed between said chelating compound and a metallic element through a coordinate bond is useful as a diagnostic or therapeutic agent for hepatobiliary organs and tissues.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: December 28, 1993
    Assignee: Nihon Medi-Physics Co., Ltd.
    Inventors: Shigemi Seri, Hirohiko Yamauchi, Makoto Azuma, Yoji Arata
  • Patent number: 5196576
    Abstract: A chelating compound of the formula:(R-NHOC-CH.sub.2).sub.n --A--(CH.sub.2 COOH).sub.m (I)wherein R is an aromatic ring-containing organic group, A is a residue of an aminopolyacetic acid excluding acetic acid groups (--CH.sub.2 COOH) therefrom, m is an integer of at least two and n is an integer of 1 or 2, or its salt, which has a specificity to a hepatobiliary system so that a complex formed between said chelating compound and a metallic element through a covalent bond is useful as a diagnostic or therapeutic agent for hepatobiliary organs and tissues.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: March 23, 1993
    Assignee: Nihon Medi-Physics Co., Ltd.
    Inventors: Shigemi Seri, Hirohiko Yamauchi, Makoto Azuma, Yoji Arata
  • Patent number: 5138039
    Abstract: A chelating compound of the formula:(R--NHOC--CH.sub.2).sub.n --A--(CH.sub.2 COOH).sub.m (I)wherein R is an aromatic ring-containing organic group, A is a residue of an aminopolyacetic acid excluding acetic acid groups (--CH.sub.2 COOH) therefrom, m is an integer of at least two and n is an integer of 1 or 2, or its salt, which has a specificity to a hepatobiliary system so that a complex formed between said chelating compound and a metallic element through a coordinate bond is useful and a diagnostic or therapeutic agent for hepatobiliary organs and tissues.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: August 11, 1992
    Assignee: Nihon Medi-Physics Co., Ltd
    Inventors: Shigemi Seri, Hirohiko Yamauchi, Makoto Azuma, Yoji Arata
  • Patent number: 5096693
    Abstract: A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: March 17, 1992
    Assignee: Nihon Medi-Physics Co., Ltd.
    Inventors: Makoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
  • Patent number: 5071636
    Abstract: A polyaminedithiol compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.11 and R.sub.12 are each a lower alkyl group, R.sub.21 is a hydrogen atom or a lower alkyl group, and R.sub.3 and R.sub.13 are each a hydrogen atom or a nitrogen-containing organic group, provided that at least one of R.sub.3 and R.sub.13 is a nitrogen-containing organic group, which is used for imaging of the regional cerebral blood flow.
    Type: Grant
    Filed: December 28, 1988
    Date of Patent: December 10, 1991
    Assignee: Nihon Medi-Physics Co., Ltd.
    Inventors: Hirohiko Yamauchi, Jun Takahashi, Sakae Okano, Shigemi Seri, Makoto Azuma
  • Patent number: 5015462
    Abstract: A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.
    Type: Grant
    Filed: June 8, 1989
    Date of Patent: May 14, 1991
    Assignee: Nihon Medi-Physics Co. Ltd.
    Inventors: Makoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
  • Patent number: 4996312
    Abstract: A porphyrin compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each --CH.dbd.CH.sub.2, --CH.sub.2 CHJ.sub.3, --CH(O-lower alkanoyl)CH.sub.3, --CH(OR)CH.sub.3 or --CH(O-lower alkylene-OR)CH.sub.3 ; R.sub.3 is --H, --COOH, --COO-lower alkyl, --COO-lower alkylene-OR or --COO-lower alkylene-OOC-Z; R.sub.4 is --H, -lower alkyl or -lower alkylene-OR; R is --H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R.sub.3 therefrom; A is --CH.sub.2 -- or --CO--; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfunctional carboxyl compound, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: February 26, 1991
    Assignees: Nihon Medi-Physics Co., Ltd., Toyo Hakka Kogyo Co., Ltd.
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata, Hirohiko Yamauchi, Nobuo Ueda, Masaaki Hazue
  • Patent number: 4880616
    Abstract: A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.
    Type: Grant
    Filed: December 17, 1987
    Date of Patent: November 14, 1989
    Assignee: Nihon Medi-Physics Co., Ltd
    Inventors: Makoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
  • Patent number: 4849207
    Abstract: A porphyrin compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each --CH.dbd.CH.sub.2, --CH.sub.2 CH.sub.3, --CH(O-lower alkanoyl)CH.sub.3, --CH(OR)CH.sub.3 or --CH(O-lower alkylene-OR)CH.sub.3 ; R.sub.3 is --H, --COOH, --COO-lower alkyl, --COO-lower alkylene-OR or --COO-lower alkylene-OOC-Z; R.sub.4 is --H, -lower alkyl or -lower alkylene-OR; R is --H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R.sub.3 therefrom; A is --CH.sub.2 -- or --CO--; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfuntional carboxyl compound, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: July 18, 1989
    Assignees: Nihon Medi-Physics Co., Ltd., Toyo Hakka Kogyo Co., Ltd.
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata, Hirohiko Yamauchi, Nobuo Ueda, Masaaki Hazue