Abstract: [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided. [Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.

Abstract: The present invention provides an organic thin film that imparts an excellent electron injection property and an excellent electron transport property when it is used as an electron injection layer of an organic EL device, a coating composition suitable for producing the organic thin film, and an organic EL device material for the organic thin film and the coating composition.

Abstract: The present invention aims to provide an organic thin film that imparts an excellent electron injection property and an excellent electron transport property when it is used as an electron injection layer of an organic EL device. The present invention relates to an organic thin film, which is a single film containing a first material which is a hexahydropyrimidopyrimidine compound having a structure of the following formula (1) and a second material which transports electrons, or a laminate film including a film containing the first material and a film containing the second material, wherein R1 is an optionally substituted aromatic hydrocarbon group, an optionally substituted aromatic heterocyclic group, an optionally substituted arylalkylene group, an optionally substituted divalent to tetravalent acyclic or cyclic hydrocarbon group, a group of a combination of two or more of these groups, or a group of a combination of one or more of these groups and a nitrogen atom; and n is an integer of 1 to 4.

Abstract: Compounds of formula (I): in which the variables are defined herein, are useful for the treatment of cancer in patients which express the EGFR T790M mutation.

Abstract: [Problem] A compound which is useful as an inhibitor on EGFR T790M mutation kinase activity is provided. [Means for Solution] The present inventors have investigated a compound having an inhibitory action on an EGFR T790M mutation kinase, and have found that a pyrazinecarboxamide compound has an inhibitory action on an EGFR T790M mutation kinase, thereby completing the present invention.

Abstract: A work vehicle includes a front loader mounted at a front portion of the work vehicle to be vertically pivotable, a driving control device, and a canopy device for covering the driving control device from above, the canopy device including a roof disposed upwardly of the driving control device and a support body for supporting the roof. The roof includes a front visor portion which projects, in a plan view thereof, to a position same as or more forwardly of a front end portion of the driving control device. To a lower face of said front visor portion, there are attached a pair of right and left front illumination lamps, and there is provided an upper concave portion at the right/left center thereof. A lower face of the upper concave portion is formed as an inclined face which is inclined upward from a rear portion to a front edge of the front visor portion so as to be located at a higher position than the attaching position of the front illumination lamps.

Abstract: [Problem] A compound, which can be used for preventing or treating diseases, in which 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided. [Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11?-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.

Abstract: A work apparatus to be mounted to a work vehicle includes: a pair of cylindrical masts 35 disposed erect on right and left sides of a vehicle body having a control valve; a boom 91 pivotally supported to the masts; an implement pivotally supported to the boom; a boom cylinder 60 for pivoting the boom; an implement cylinder 61 for operating the implement; a boom piping system communicating the control valve with the boom cylinder; and an implement piping system communicating the control valve with the implement cylinder; wherein a channel constituting member 84 constituting the boom piping system extends vertically within each mast; one end of the channel constituting member 84 extends to the outside at a lower portion of the mast to be connected with the control valve; and the other end of the channel constituting member 84 extends to the outside at an upper portion of the mast 35 to be connected with boom cylinder 60.

Abstract: This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.

Abstract: [Problem] A compound which is useful as an anti-obesity agent is provided. [Means for Solution] The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases, and as a result, they have found that the diacylethylenediamine compound of the present invention has an excellent DGAT1 inhibitory action, thereby completing the present invention. That is, the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.

Abstract: [Problem] A compound, which can be used for preventing or treating diseases, in which 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided. [Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11?-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.

Abstract: A vibration-isolating device for a steering wheel of a travelling working vehicle equipped with a wheel steering mechanism includes a first steering shaft (32) that transmits rotational displacement, the first steering shaft being operatively connected to the steering wheel (7); a second steering shaft (33) that transmits rotational displacement, the second steering shaft being operatively connected to the wheel steering mechanism (P, 23); and a vibration-isolating connecting mechanism (31) that operatively connects the first steering shaft (32) and the second steering shaft (33) to each other so that rotational displacement can be transmitted. When the angles of rotational displacement of the first steering shaft (32) and the second steering shaft (33) are within ranges of rotation angles for linearly driving the vehicle, rotational displacement cannot be transmitted between the first steering shaft (32) and the second steering shaft (33).

Abstract: There is provided a compound which can be used for therapy of diseases in which 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) participates, in particular diabetes, insulin resistance. It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11?-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.

Abstract: A work vehicle with a working implement, comprising: a control lever 49 for controlling the working implement 3, the control lever being rockably disposed laterally of a driver's seat 16 mounted on a vehicle body 7; a control valve 52 disposed laterally of the vehicle body for controlling actuators 32, 44 that drive the working implement; and interlocking links 56, 57 for interlocking the control lever and spools 54, 55 of the control valve 52, and transmitting rocking of the control lever to the spools; wherein the control lever 49 and the spools 54, 55 are staggered transversely and longitudinally of the vehicle body 7, and the interlocking links 56, 57 are bent, one end of each interlocking link being connected to a first link connector 72, 68c connected to the control lever, the other end of each interlocking link being connected to a second link connector connected to one of the spools.

Abstract: A vibration-isolating device for a steering wheel of a travelling working vehicle equipped with a wheel steering mechanism includes a first steering shaft (32) that transmits rotational displacement, the first steering shaft being operatively connected to the steering wheel (7); a second steering shaft (33) that transmits rotational displacement, the second steering shaft being operatively connected to the wheel steering mechanism (P, 23); and a vibration-isolating connecting mechanism (31) that operatively connects the first steering shaft (32) and the second steering shaft (33) to each other so that rotational displacement can be transmitted. When the angles of rotational displacement of the first steering shaft (32) and the second steering shaft (33) are within ranges of rotation angles for linearly driving the vehicle, rotational displacement cannot be transmitted between the first steering shaft (32) and the second steering shaft (33).

Abstract: This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.

Abstract: [Problem] To provide a compound which may be used in treating diseases in which 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) is concerned, especially diabetes and insulin resistance. [Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11?-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.

Abstract: A boom assembly is bent at a longitudinal center portion thereof to present an upwardly convex shape. The assembly includes a front boom body and a rear boom body. The front boom body and the rear main body each includes a main body consisting essentially of a pair of right and left lateral plates and a top plate interconnecting upper edges of the respective lateral plates. The main body is formed with an upper face and a lower edge thereof being bent in a longitudinal direction thereof into an arc face having a predetermined radius of curvature. The front or rear main body further includes a bottom plate disposed downwardly of the top plate and between the right and left lateral plates. Each main body is formed by bending a plate member into a reverse U-shaped cross section and each bottom plate is comprised of a plate member provided separately from the plate member forming the main body.

Abstract: A work vehicle includes a front loader mounted at a front portion of the work vehicle to be vertically pivotable, a driving control device, and a canopy device for covering the driving control device from above, the canopy device including a roof disposed upwardly of the driving control device and a support body for supporting the roof. The roof includes a front visor portion which projects, in a plan view thereof, to a position same as or more forwardly of a front end portion of the driving control device. To a lower face of said front visor portion, there are attached a pair of right and left front illumination lamps, and there is provided an upper concave portion at the right/left center thereof. A lower face of the upper concave portion is formed as an inclined face which is inclined upward from a rear portion to a front edge of the front visor portion so as to be located at a higher position than the attaching position of the front illumination lamps.

Abstract: A work vehicle includes a pair of, right and left booms detachably attached to a vehicle body, an implement attached to leading ends of the booms and a stand for supporting the booms with the implement being placed on a ground surface when the booms are detached from the vehicle body. The stand includes a pair of, right and left stand members provided in correspondence with the right and left booms and a stand connecting member for interconnecting the stand members. Each stand member is attached to the boom corresponding thereto in such a manner that the stand is movable between a use position in which each stand member projects downwardly from the boom for supporting the boom and a non-use position in which each stand member extends along the boom.