Patents by Inventor Hiromi Hijiya

Hiromi Hijiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5652124
    Abstract: .alpha.-Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the .alpha.-bond, is formed by a saccharide-transferring enzyme in a liquid containing hesperidin and .alpha.-glucosyl saccharide. The .alpha.-glycosyl hesperidin is easily recovered from the reaction mixture with a synthetic macroporous resin. .alpha.-Glycosyl hesperidin is superior in water-solubility, substantially tasteless and odorless, free of toxicity, and readily hydrolyzable in vivo into hesperidin and D-glucose to exhibit the physiological activity inherent to hesperidin. Thus, .alpha.-glycosyl hesperidin is favorably usable in vitamin P-enriching agents, foods, beverages, tobaccos, foods, pet foods, pharmaceuticals for susceptive diseases, cosmetics and plastics.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: July 29, 1997
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Toshio Miyake
  • Patent number: 5627157
    Abstract: .alpha.-Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the .alpha.-bond, is formed by a saccharide-transferring enzyme in a liquid containing hesperidin and .alpha.-glucosyl saccharide. The .alpha.-glycosyl hesperidin is easily recovered from the reaction mixture with a synthetic macroporous resin. .alpha.-Glycosyl hesperidin is superior in water-solubility, substantially tasteless and odorless, free of toxicity, and readily hydrolyzable in vivo into hesperidin and D-glucose to exhibit the physiological activity inherent to hesperidin. Thus, .alpha.-glycosyl hesperidin is favorably usable in vitamin P-enriching agents, foods, beverages, tobaccos, foods, pet foods, pharmaceuticals for susceptive diseases, cosmetics and plastics.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: May 6, 1997
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Toshio Miyake
  • Patent number: 5145781
    Abstract: Alpha-glycosyl rutin is formed at a high concentration by allowing a saccharide-transferring enzyme to act on a high-rutin content liquid in suspension or solution to effect saccharide-transfer reaction. The resultant alpha-glycosyl rutin is easily recovered from the reaction mixture by allowing it to contact with a synthetic macroreticular resin. Alpha-glycosyl rutin is superior in water-solubility, resistance to light and stability to intact rutin, as well as having the physiological activities as intact rutin has. Thus, alpha-glycosyl rutin is favorably usable as a yellow coloring agent, antioxidant, stabilizer, fading-preventing agent, quality-improving agent, preventive, remedy, uv-absorbent and deterioration-preventing agent in foods, beverages, tobaccos, cigarettes, feeds, pet foods, pharmaceuticals for susceptive diseases, cosmetics including skin-refining agent and skin-whitening agent, and plastics, in addition to the use in vitamin P-enriching agents.
    Type: Grant
    Filed: March 7, 1990
    Date of Patent: September 8, 1992
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Yukio Suzuki, Kei Suzuki, Masaru Yoneyama, Hiromi Hijiya, Toshio Miyake
  • Patent number: 4927636
    Abstract: Pullulan forms an association complex with PEG in a hydrous system. The assocation complex, as well as its pullulan and PEG components, exerts a decreased solubility in water. The association reduces or even eliminates the excessively high water-solubility, threading and stickiness of pullulan so that this extends the uses of pullulan and PEG such as those in gradually disintegrable- and sustained release-shaped articles for consumer's products, toiletries, cosmetics, pharmaceuticals and feeds.
    Type: Grant
    Filed: November 3, 1987
    Date of Patent: May 22, 1990
    Assignee: 501 Kabushiki Kaisha Hayashibara Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Toshio Miyake
  • Patent number: 4917916
    Abstract: The present invention relates to anhydrous crystals of maltitol and the whole crystalline hydrogenated starch hydrolysate mixture solid containing the crystals, and processes for the production and use thereof.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: April 17, 1990
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Mamoru Hirao, Hiromi Hijiya, Toshio Miyaka
  • Patent number: 4831022
    Abstract: A novel EPA/CD inclusion compound and a food product containing the same are disclosed. The undesirable odor of EPA is masked by including it into such EPA/CD inclusion compound. Gamma-CD is most favorable because it includes much more EPA, and highly stabilizes it. The EPA/CD inclusion compound is advantageously usable in perorally- or parenterally-usable products directed to the promotion or maintenance of health.
    Type: Grant
    Filed: September 15, 1988
    Date of Patent: May 16, 1989
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Masakazu Mitsuhashi, Toshi Miyake
  • Patent number: 4789559
    Abstract: The present invention relates to anhydrous crystals of maltitol and the whole crystalline hydrogenated starch hydrolysate mixture solid containing the crystals, and processes for the production and use thereof.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: December 6, 1988
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Mamoru Hirao, Hiromi Hijiya, Toshio Miyaka
  • Patent number: 4777162
    Abstract: A novel EPA/CD inclusion compound and a food product containing the same are disclosed. The undesirable odor of EPA is masked by including it into such EPA/CD inclusion compound. Gamma-CD is most favorable because it includes much more EPA, and highly stabilizes it. The EPA/CD inclusion compound is advantageously usable in perorally- or parenterally-usable products directed to the promotion or maintenance of health.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: October 11, 1988
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Masakazu Mitsuhashi, Toshio Miyake
  • Patent number: 4775749
    Abstract: A novel EPA/CD inclusion compound and a food product containing the same are disclosed. The undesirable odor of EPA is masked by including it into such EPA/CD inclusion compound. Gamma-CD is most favorable because it includes much more EPA, and highly stabilizes it. The EPA/CD inclusion compound is advantageously usable in perorally- or parenterally-usable products directed to the promotion or maintenance of health.
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: October 4, 1988
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Masakazu Mitsuhashi, Toshio Miyake
  • Patent number: 4725387
    Abstract: The present invention relates to anhydrous crystals of maltitol and the whole crystalline hydrogenated starch hydrolysate mixture solid containing the crystals, and processes for the production and use thereof.
    Type: Grant
    Filed: January 30, 1985
    Date of Patent: February 16, 1988
    Assignee: Kabushiki Kaisha Hayashibara Seitbutsu Kagaku Kenkyujo
    Inventors: Mamoru Hirao, Hiromi Hijiya, Toshio Miyaka
  • Patent number: 4717765
    Abstract: The present invention relates to anhydrous crystals of maltitol and the whole crystalline hydrogenated starch hydrolysate mixture solid containing the crystals, and processes for the production and use thereof.
    Type: Grant
    Filed: December 9, 1985
    Date of Patent: January 5, 1988
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Mamoru Hirao, Hiromi Hijiya, Toshio Miyaka
  • Patent number: 4623394
    Abstract: A novel molded article exhibiting a gradual disintegration effect is prepared with pullulan. The effect is imparted by incorporating heteromannan into a pullulan molded article in an amount not exceeding the weight of the pullulan used. Galactomannans (e.g. guar gum, tara gum, and locust bean gum) and glucomannans (e.g. konjak mannan) are feasible as the heteromannan. The molded article is advantageously usable for industrial materials, pharmaceuticals, consumers' products, etc.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: November 18, 1986
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Satoshi Nakamura, Hiromi Hijiya, Toshio Miyake
  • Patent number: 4621137
    Abstract: The present invention relates to food products containing a novel alpha-glycosyl ginsenoside wherein one or more alpha-glucosyl moieties are bound to ginsenoside residue, and a process for producing the food products. Such alpha-glycosyl ginsenoside is obtainable by subjecting an aqueous solution of ginsenoside and an alpha-glucosyl saccharide to an alpha-glucosyl transferase.
    Type: Grant
    Filed: December 16, 1983
    Date of Patent: November 4, 1986
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Toshio Miyake, Hiromi Hijiya, Shinji Suzuki, Teruo Matsumoto
  • Patent number: 4562020
    Abstract: A continuous process for producing a self-supporting glucan film, comprises casting an aqueous glucan solution on the surface of a corona-treated endless heat-resistant plastic belt, drying the glucan solution thereon while heating, and releasing the resultant self-supporting glucan film therefrom. Suitable glucans are those which substantially consist of repeating maltotriose units, such as pullulan or elsinan.
    Type: Grant
    Filed: December 1, 1983
    Date of Patent: December 31, 1985
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Toshio Miyake
  • Patent number: 4557927
    Abstract: Novel alpha-glycosylated soybean glycosides wherein one or more glucosyl residues are bound to the soybean glycoside moiety are prepared. Alpha-glycosylation can be enzymatically achieved by subjecting an aqueous solution containing a soybean glycoside, e.g. soyasaponin or isoflavonoid, and an alpha-glucosyl saccharide to an alpha-glucosyl transferase. Suitable alpha-glucosyl saccharides are liquefied starch, partially hydrolyzed starch and sucrose. Alpha-glucosidase, alpha-amylase, cyclodextrin glucanotransferase, dextransucrase, dextran dextrinase and amylosucrase are usable as the alpha-glucosyl transferase. Since in the alpha-glycosylated soybean glycosides the undesirable bitter, astringent, harsh and lingering choky tastes which are common in intact soybean glycosides are reduced or even eliminated by the alpha-glycosylation, they are suitable for use in food products or orally-usable products wherein taste is an important factor.
    Type: Grant
    Filed: February 22, 1984
    Date of Patent: December 10, 1985
    Assignee: Kabushiki Kaisha Hoyashibara
    Inventors: Toshio Miyake, Hiromi Hijiya, Shinji Suzuki, Teruo Matsumoto
  • Patent number: 4537763
    Abstract: New .alpha.-glycosyl glycyrrhizins bearing two or more .alpha.-glucose residues are prepared. Such .alpha.-glycosylation is carried out by subjecting an aqueous solution of glycyrrhizin (or a salt thereof) and an amylaceous substance (e.g. starch or cyclodextrin) to the enzymatic action of an .alpha.-glycosyl transferase (e.g. cyclodextrin glucanotrasferase). The .alpha.-glycosyl glycyrrhizins are low-caloric, low-cariogenic, mild, non-bitter, non-lingering sweeteners which may be advantageously incorporated into foods, beverages, cosmetics, dentifrices and drugs.
    Type: Grant
    Filed: June 11, 1982
    Date of Patent: August 27, 1985
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Toshio Miyake, Hiromi Hijiya
  • Patent number: 4408041
    Abstract: The present invention relates to anhydrous crystals of maltitol and the whole crystalline hydrogenated starch hydrolysate mixture solid containing the crystals, and processes for the production and use thereof.
    Type: Grant
    Filed: November 13, 1981
    Date of Patent: October 4, 1983
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Mamoru Hirao, Hiromi Hijiya, Toshio Miyaka