Abstract: The present invention provides a versatile method which has a high diagnostic accuracy rate on the suitability of esophageal cancer for endoscopic therapy and enables the simple and objective determination of the suitability or unsuitability for endoscopic therapy.

Abstract: Disclosed is a method for assisting prediction of onset of cerebral infarction, based on the number of red blood cells contained in a blood sample collected from a subject, comprising the steps of: calculating an exponent value for the prediction from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method, comparing the exponent value with a reference range, and suggesting that the subject develops cerebral infarction when the exponent value is outside the reference range.

Abstract: A highly practical biomarker that is specific to esophageal cancer and minimally invasive is provided. hsa-miR-619-5p in urine, hsa-milt-1273f in urine, hsa-miR-3135b in urine, hsa-miR-4327 in urine, and hsa-miR-150-3p in urine were identified as esophageal cancer biomarkers. Esophageal cancer contraction is determined by using the expression level of these microRNAs as an index.

Abstract: The present invention provides a colorectal cancer diagnostic marker which can determine the presence or absence of colorectal cancer with high accuracy and which can also detect early-stage colorectal cancer with high sensitivity; a method which is for assisting the diagnosis of colorectal cancer, and measures an expression level of the colorectal cancer diagnostic marker; a method for collecting data for diagnosis of colorectal cancer; a method for diagnosing colorectal cancer; a method for treating colorectal cancer; a colorectal cancer diagnostic kit including a primer that is specific to the colorectal cancer diagnostic marker; and a therapeutic agent for colorectal cancer containing an inhibitor of the colorectal cancer diagnostic marker. The colorectal cancer diagnostic marker of the present invention is at least one microRNA selected from a group consisting of hsa-miR-129-1-3p, hsa-miR-566, and hsa-miR-598-5p.

Abstract: Disclosed is a method for assisting prediction of onset of cerebral infarction, based on the number of red blood cells contained in a blood sample collected from a subject, comprising the steps of: calculating an exponent value for the prediction from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method, comparing the exponent value with a reference range, and suggesting that the subject develops cerebral infarction when the exponent value is outside the reference range.

Abstract: A pattern matching unit performs pattern matching on present data obtained this time in clinical examination of a part of a subject and previous data obtained last time in the clinical examination of the part with reference patterns. Reference patterns that are most closely approximate to the present data and the previous data are selected. A distance calculator calculates a distance between selected reference patterns. A determining unit determines whether a re-examination is necessary based on the distance.

Abstract: A blood cell analyzer comprising: a detector for detecting predetermined component of leukocytes contained in a specimen; and a controller, including a memory under the control of a processor, the memory storing: correlation information relating to the correlation between leukocyte distribution data and either stab neutrophil or segmented leukocyte classification data; and instructions enabling the processor to carry out operations, comprising: (a) obtaining leukocyte distribution data of a subject based on the detection results of the detector; (b) obtaining the stab neutrophil or segmented leukocyte classification data based on the correlation information and the leukocyte distribution data of the subject; and (c) outputting the obtained stab neutrophil or segmented leukocyte classification data. A blood cell analyzing method and a computer program product is also disclosed.

Abstract: Electrophoresis waveform data and a prediction equation for predicting the amount of a substance in an analyte or the presence of a disease in the living body from which the analyte was obtained are recorded. The prediction equation is a regression equation in which the explanatory variable is an absorbance value corresponding to a mobility in corrected waveform data generated as a result of electrophoresis waveform data on a plurality of analytes, and the criterion variable is the amount of the substance or the presence of a disease. The test value prediction method includes a step of generating corrected waveform data by performing normalization and area correction on the electrophoresis waveform data recorded in the recording unit, and a step of calculating a prediction value of the amount of the specific substance by substituting the absorbance value from the mobility, with an absorbance value from the corrected waveform data.

Abstract: The object of the present invention is to provide an apparatus, a method, a program, and a self-organizing map which are capable of normalizing mobility without using a marker, as well as a substance detection method, a program, a detection rule creating method, and a data structure which use normalized mobility. The mobility normalizing method comprises the steps of determining a plurality of warping functions converting data to be corrected, which is unit time sequence data obtained by measuring mobility, to the respective plurality of reference waveform data sets, and a DTW distance associated with each warping function; evaluating a minimum value of the plurality of DTW distances, and determining the warping function associated with the determined minimum DTW distance; determining a slope and an intercept of a straight line approximating the determined warping function; and correcting the data to be corrected using a linear function specified by the slope and the intercept.

Abstract: A heat sink capable of permitting heat transfer from an electronic component to the heat sink to be effectively promoted while reducing a manufacturing cost of the heat sink and increasing yields thereof. The heat sink includes a base plate adaptable to be kept in direct contact with an electronic component which requires that heat be dissipated therefrom during operation thereof and radiation fins arranged so as to project from the base plate. The base plate includes a main base plate section made of a main material of which the radiation fins are made and a heat transfer promoting base plate section made of a heat transfer promoting material different from the material of which the main base plate section is made. The heat transfer promoting material is integrated with said main material at a stage at which working of a workpiece.

Abstract: A blood cell analyzer comprising: a detector for detecting predetermined component of leukocytes contained in a specimen; and a controller, including a memory under the control of a processor, the memory storing: correlation information relating to the correlation between leukocyte distribution data and either stab neutrophil or segmented leukocyte classification data; and instructions enabling the processor to carry out operations, comprising: (a) obtaining leukocyte distribution data of a subject based on the detection results of the detector; (b) obtaining the stab neutrophil or segmented leukocyte classification data based on the correlation information and the leukocyte distribution data of the subject; and (c) outputting the obtained stab neutrophil or segmented leukocyte classification data. A blood cell analyzing method and a computer program product is also disclosed.

Abstract: Respective components of a leukocyte particle size pattern that includes a plurality of cellular component fractions are separated by performing a mixture density approximation using an EM algorithm, and characteristic parameters of each fraction are clustered. A similarity search with attention paid to a distribution pattern of a cell group of interest is thereby executed. An algorithm capable of doing a highly accurate similarity search from general viewpoints such as a search for the respective cellular components of a leukocyte or a combination of the respective components is developed. In addition, information useful for a diagnosis is provided.

Abstract: A test value prediction apparatus, a test value prediction method, and a test value predicting program, capable of accurately predicting the amount of a specific substance, the presence or absence of a disease, and the like, using electrophoresis waveform.

Abstract: The object of the present invention is to provide an apparatus, a method, a program, and a self-organizing map which are capable of normalizing mobility without using a marker, as well as a substance detection method, a program, a detection rule creating method, and a data structure which use normalized mobility. The mobility normalizing method comprises the steps of determining a plurality of warping functions converting data to be corrected, which is unit time sequence data obtained by measuring mobility, to the respective plurality of reference waveform data sets, and a DTW distance associated with each warping function; evaluating a minimum value of the plurality of DTW distances, and determining the warping function associated with the determined minimum DTW distance; determining a slope and an intercept of a straight line approximating the determined warping function; and correcting the data to be corrected using a linear function specified by the slope and the intercept.

Abstract: Respective components of a leukocyte particle size pattern that includes a plurality of cellular component fractions are separated by performing a mixture density approximation using an EM algorithm, and characteristic parameters of each fraction are clustered. A similarity search with attention paid to a distribution pattern of a cell group of interest is thereby executed. An algorithm capable of doing a highly accurate similarity search from general viewpoints such as a search for the respective cellular components of a leukocyte or a combination of the respective components is developed. In addition, information useful for a diagnosis is provided.

Abstract: A pattern matching unit performs pattern matching on present data obtained this time in clinical examination of a part of a subject and previous data obtained last time in the clinical examination of the part with reference patterns. Reference patterns that are most closely approximate to the present data and the previous data are selected. A distance calculator calculates a distance between selected reference patterns. A determining unit determines whether a re-examination is necessary based on the distance.

Abstract: The clinical test analyzing device (100) includes an appearance pattern storing section (301) that stores a plurality of appearance patterns on analyzing results of a prescribed plurality of items in clinical tests for a prescribed population, a clinical test result input section (302) that inputs analyzing results of the prescribed plurality of items in clinical tests for a subject, and a resemblance calculation section (303) that calculates the degree of resemblance of the analyzing result to the most resembling appearance pattern, based on the analyzing results that was input by the clinical test result input section (302) and the plurality of appearance patterns stored in the appearance pattern storing section (301).

Abstract: A heat sink capable of permitting heat transfer from an electronic component to the heat sink to be effectively promoted while reducing a manufacturing cost of the heat sink and increasing yields thereof. The heat sink includes a base plate adaptable to be kept in direct contact with an electronic component which requires that heat be dissipated therefrom during operation thereof and radiation fins arranged so as to project from the base plate. The base plate includes a main base plate section made of a main material of which the radiation fins are made and a heat transfer promoting base plate section made of a heat transfer promoting material different from the material of which the main base plate section is made. The heat transfer promoting material is integrated with said main material at a stage at which working of a workpiece.

Abstract: A heat sink capable of permitting heat transfer from an electronic component to the heat sink to be effectively promoted while reducing a manufacturing cost of the heat sink and increasing yields thereof. Also, a method for manufacturing such a heat sink. The heat sink includes a base plate adaptable to be kept in direct contact with an electronic component which requires that heat be dissipated therefrom during operation thereof and radiation fins arranged so as to project from the base plate. The base plate includes a main base plate section made of a main material of which the radiation fins are made and a heat transfer promoting base plate section made of a heat transfer promoting material different from the material of which the main base plate section is made. The heat transfer promoting material is integrated with said main material at a stage at which working of a workpiece.

Abstract: An image processing apparatus comprises a memory for storing image data to be formed into an image, a memory holding unit for holding the content of the memory, and a control unit for stopping the memory holding operation by memory holding unit during a stand-by period of the image forming operation.