Patents by Inventor Hiromi Torii

Hiromi Torii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process of making ?-aminooxyketone/?-aminooxyaldehyde and ?-hydroxyketone/?-hydroxyaldehyde compounds and a process of making reaction products from cyclic ?, ?-unsaturated ketone substrates and nitroso substrates
    Patent number: 8372985
    Abstract: The present invention is directed to a process of making ?-aminooxyketone and ?-hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV): wherein Xa-Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the ?-aminooxyketone compound formed to the ?-hydroxyketone compound. The present invention results in ?-aminooxyketone and ?-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol/Michael reaction. The substrates of this reaction are generally cyclic ?,?-unsaturated ketone substrate and a nitroso substrate.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: February 12, 2013
    Assignee: Japan Science and Technology Agency
    Inventors: Norie Momiyama, Hiromi Torii, Susumu Saito, Hisashi Yamamoto, Yuhei Yamamoto
  • PROCESS OF MAKING ALPHA-AMINOOXYKETONE/ALPHA-AMINOOXYALDEHYDE AND ALPHA-HYDROXYKETONE/ALPHA-HYDROXYALDEHYDE COMPOUNDS AND A PROCESS MAKING REACTION PRODUCTS FROM CYCLIC ALPHA, BETA-UNSATURATED KETONE SUBSTRATES AND NITROSO SUBSTRATES
    Publication number: 20120302792
    Abstract: The present invention is directed to a process of making ?-aminooxyketone and ?-hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV): wherein Xa-Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the ?-aminooxyketone compound formed to the ?-hydroxyketone compound. The present invention results in ?-aminooxyketone and ?-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol/Michael reaction. The substrates of this reaction are generally cyclic ?,?-unsaturated ketone substrate and a nitroso substrate.
    Type: Application
    Filed: August 3, 2012
    Publication date: November 29, 2012
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: NORIE MOMIYAMA, HIROMI TORII, SUSUMU SAITO, HISASHI YAMAMOTO, YUHEI YAMAMOTO
  • Process of making alpha-aminooxyketone/alpha-aminooxyaldehyde and alpha-hydroxyketone/alpha-hydroxyaldehyde compounds and a process making reaction products from cyclic alpha, beta-unsaturated ketone substrates and nitroso substrates
    Patent number: 8252941
    Abstract: The present invention is directed to a process of making ?-aminooxyketone and ?-hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV): wherein Xa—Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the ?-aminooxyketone compound formed to the ?-hydroxyketone compound. The present invention results in ?-aminooxyketone and ?-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol/Michael reaction. The substrates of this reaction are generally cyclic ?,?-unsaturated ketone substrate and a nitroso substrate.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: August 28, 2012
    Assignee: Japan Science and Technology Agency
    Inventors: Norie Momiyama, Hiromi Torii, Susumu Saito, Hisashi Yamamoto, Yuhei Yamamoto
  • Process of making ?-aminooxyketone/?-aminooxyaldehyde and ?-hydroxyketone/?-hydroxyaldehyde compounds and a process making reaction products from cyclic ?,?-unsaturated ketone substrates and nitroso substrates
    Patent number: 7872123
    Abstract: The present invention is directed to a process of making ?-aminooxyketone and ?-hydroxyketone compounds. The synthetic pathway involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV): wherein Xa-Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the ?-aminooxyketone compound formed to the ?-hydroxyketone compound which results in ?-aminooxyketone and ?-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol/Michael reaction involving a cyclic ?,?-unsaturated ketone substrate and a nitroso substrate. This methodology involves reacting the cyclic ?,?-unsaturated ketone substrate and the nitroso substrate in the presence of a proline-based catalyst, to provide a heterocyclic product.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: January 18, 2011
    Assignee: Japan Science And Technology Agency
    Inventors: Norie Momiyama, Hiromi Torii, Susumu Saito, Hisashi Yamamoto, Yuhei Yamamoto
  • PROCESS OF MAKING ALPHA-AMINOOXYKETONE/ALPHA-AMINOOXYALDEHYDE AND ALPHA-HYDROXYKETONE/ALPHA-HYDROXYALDEHYDE COMPOUNDS AND A PROCESS MAKING REACTION PRODUCTS FROM CYCLIC ALPHA, BETA-UNSATURATED KETONE SUBSTRATES AND NITROSO SUBSTRATES
    Publication number: 20100099915
    Abstract: The present invention is directed to a process of making ?-aminooxyketone and ?-hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV): wherein Xa—Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the ?-aminooxyketone compound formed to the ?-hydroxyketone compound. The present invention results in ?-aminooxyketone and ?-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol/Michael reaction. The substrates of this reaction are generally cyclic ?,?-unsaturated ketone substrate and a nitroso substrate.
    Type: Application
    Filed: October 14, 2009
    Publication date: April 22, 2010
    Inventors: Norie Momiyama, Hiromi Torii, Susumu Saito, Hisashi Yamamoto, Yuhei Yamamoto
  • Process of making alpha-aminooxyketone/alpha-aminooxyaldehyde and alpha-hydroxyketone/alpha-hydroxyaldehyde compounds and a process making reaction products from cyclic alpha,beta-unsaturated ketone substrates and nitroso substrates
    Publication number: 20070037973
    Abstract: The present invention is directed to a process of making ?-aminooxyketone and ?-hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV): wherein Xa—Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the ?-aminooxyketone compound formed to the ?-hydroxyketone compound. The present invention results in ?-aminooxyketone and ?-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol/Michael reaction. The substrates of this reaction are generally cyclic ?,?-unsaturated ketone substrate and a nitroso substrate.
    Type: Application
    Filed: October 25, 2006
    Publication date: February 15, 2007
    Inventors: Norie Momiyama, Hiromi Torii, Susumu Saito, Hisashi Yamamoto, Yuhei Yamamoto