Patents by Inventor Hiromichi Yonekawa

Hiromichi Yonekawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hairless Transgenic Animal
    Publication number: 20100235926
    Abstract: The present invention provides a hairless transgenic nonhuman animal used in the development of a therapy for dermatitis such as human atopic dermatitis and drug discovery. Specifically, the present invention provides a transgenic nonhuman animal, into which recombinant DNA comprising a heparin-binding EGF gene and a type 2 keratin gene promoter for regulating expression of the above gene has been introduced.
    Type: Application
    Filed: February 8, 2006
    Publication date: September 16, 2010
    Inventors: Hiromichi Yonekawa, Toyoyuki Takada, Hiroshi Shitara, Yoshiaki Kikkawa, Rie Ishii, Kenji Kohno
  • Diabetes Model Animal
    Publication number: 20090217394
    Abstract: The present invention relates to a diabetes animal model. Specifically, the present invention relates to a transgenic nonhuman animal, into which recombinant DNA comprising a gene encoding a diphtheria toxin receptor and an insulin promoter for regulating expression of the above gene has been introduced.
    Type: Application
    Filed: February 27, 2006
    Publication date: August 27, 2009
    Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF
    Inventors: Hiromichi Yonekawa, Kunie Matsuoka, Hiroshi Shitara, Kenji Kohno
  • GFP expression vector localized in mitochondria
    Patent number: 7227052
    Abstract: A system for observing the behaviors of mitochondria during ontogeny and the dynamics of mitochondria in various tissues during pathological development is provided. A pCAGGS expression vector containing green fluorescent protein (GFP) gene and a transgenic animal characterized by expressing GFP specifically in mitochondria are provided.
    Type: Grant
    Filed: September 29, 2001
    Date of Patent: June 5, 2007
    Assignee: Tokyo Metropolitan Organization for Medical Research
    Inventors: Hiromichi Yonekawa, Hiroshi Shitara, Jun-ichi Miyazaki
  • Gfp expression vector localized in mitochondria
    Publication number: 20040154046
    Abstract: A system for observing the behaviors of mitochondria during ontogeny and the dynamics of mitochondria in various tissues during pathological development is provided. A pCAGGS expression vector containing green fluorescent protein (GFP) gene and a transgenic animal characterized by expressing GFP specifically in mitochondria are provided.
    Type: Application
    Filed: April 5, 2004
    Publication date: August 5, 2004
    Inventors: Hiromichi Yonekawa, Hiroshi Shitara, Jun-ichi Miyazaki
  • Hepatitis C animal model
    Patent number: 6429355
    Abstract: A hepatitis type C animal model into which cDNA derived from hepatitis C virus has been introduced. This animal model is useful for clarification of an onset mechanism of hepatitis C and as well as for development of means for treating the disease.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: August 6, 2002
    Assignees: Tokyo Metropolitan Institute of Medical Science, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Michinori Kohara, Takaji Wakita, Hiromichi Yonekawa, Choji Taya, Izumu Saito
  • Transgenic mouse hepatitis C virus model comprising a hepatitis C viral fragment
    Patent number: 6201166
    Abstract: Transgenic mice are described which serve as a model for Hepatitis C infection. The transgenic mice contain, in their germline and somatic cells, the Hepatitis C viral fragment CN2, N24 or CR under the control of a Cre-loxP switch-expression system. Administration of Cre to the mice results in a phenotype of increased serum GTP levels, emergence of acidophilic bodies in the liver, exfoliation of hepatic cells, hypertrophy and hyperplasia of Kupffer's cells, and conglomeration of lymphocytes.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: March 13, 2001
    Assignee: Tokyo Metropolitan Institute of Medical Science
    Inventors: Michinori Kohara, Takaji Wakita, Hiromichi Yonekawa, Choji Taya, Izumu Saito
  • Transgenic animal allergy models and methods for their use
    Patent number: 6118044
    Abstract: Transgenic mice which constitutively express an antibody-type molecule encoded by the transgene and which has an IgE heavy chain constant region and is specific for a pre-defined antigen, provide an allergic reaction to that antigen without prior sensitization and are useful as allergy models.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: September 12, 2000
    Assignees: Sankyo Company, Limited, The Tokyo Metropolitan Institute of Medical Science
    Inventors: Hajime Karasuyama, Hiromichi Yonekawa, Choji Taya, Kunie Matsuoka
  • Method for examining neurovirulence of polio virus
    Patent number: 5986171
    Abstract: The present invention relates to a method of examining the neurovirulence of a polio virus, which comprises inoculating a polio virus into the spinal cord of a transgenic mouse comprising a gene for a polio virus receptor.
    Type: Grant
    Filed: November 15, 1995
    Date of Patent: November 16, 1999
    Assignees: Japan Poliomyelitis Research Institute, Central Institute for Experimental Animals
    Inventors: Shinobu Abe, Yoshihiro Ota, So Hashizume, Satoshi Koike, Akio Nomoto, Hiromichi Yonekawa, Choji Taya, Tatsuji Nomura