Patents by Inventor Hiromu Murai
Hiromu Murai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4237132Abstract: A series of new 4,6-disubstituted 2-morpholinone derivatives were prepared either by a reaction of corresponding epoxide derivatives with phenylglycine derivatives or by the reaction of isopropanol derivatives with carboxylic acid derivatives. The new morpholinone derivatives are useful for the prevention or the treatment of arteriosclerosis.Type: GrantFiled: June 4, 1976Date of Patent: December 2, 1980Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4210671Abstract: A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:HNRR'wherein R and R' are each hydrogen, a straight chain or branched alkyl group having 3 to 15 carbon atoms, a lower alkenyl group, a cycloalkyl group, a phenyl group, a phenylalkyl group and a phenylalkyl group having a lower alkyl group at the .alpha.-position, with the proviso that such amines where both R and R' are hydrogen or where one of R and R' is hydrogen and the other is phenyl are excluded.The invention further comprises the resulting abietamide derivative reaction products, compositions containing effective blood serum cholesterol-reducing amounts of said abietamide derivatives and their use as anti-arteriosclerotic agents.Type: GrantFiled: May 12, 1975Date of Patent: July 1, 1980Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsuhide Saito, Tamiki Mori, Yasuo Yasutomi
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Patent number: 4182767Abstract: 2-Hydroxymethyl-3,4,5-trihydroxy-N-alkylpiperidines and their acid addition salts are antihyperglycemic agents. A typical example is 2-hydroxymethyl-3,4,5-trihydroxy-N-methylpiperidine.Type: GrantFiled: May 10, 1978Date of Patent: January 8, 1980Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Ichiro Shirahase
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Patent number: 4162331Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: January 24, 1977Date of Patent: July 24, 1979Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4137231Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidine is obtained from the mulberry plant through extraction, optionally with further purification through ion exchange or chromatographic treatment.Type: GrantFiled: December 20, 1976Date of Patent: January 30, 1979Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Hiroshi Enomoto, Yoshiaki Yoshikuni, Tatsuhiko Kono, Masahiro Yagi
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Patent number: 4117159Abstract: N-Phenyl and N-benzyl .DELTA..sup.8 -dihydropimaramides are antiphlogistic and serum cholesterol lowering agents. The compounds, of which N-(2-ethylphenyl)-.DELTA..sup.8 -dihydropimaramide is a representative embodiment, are prepared from reactive derivatives of .DELTA..sup.8 -dihydropimaric acid and the appropriate amine.Type: GrantFiled: February 14, 1977Date of Patent: September 26, 1978Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Yukio Fujita, Tamiki Mori, Hiroshi Enomoto, Yoshiaki Yoshikuni
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Patent number: 4109000Abstract: 5-Benzy-2-pyridine carboxylic acids, in which the benzyl group is optionally substituted by one or two like or different alkyl, halo, alkoxy, nitro, amino, acetamido, hydroxy or acetoxy groups, and the corresponding amides and esters, possess dopamine .beta.-hydroxylase inhibitory properties and are useful as blood pressure lowering agents. The compounds, of which 5-(4-chlorobenzyl)-2-pyridine carboxylic acid, 5-(4-hydroxybenzyl)-2-pyridine carboxylic acid and 5-benzyl-2-pyridine carboxylic acid are typical examples, can be prepared by a number of chemical methods.Type: GrantFiled: June 16, 1976Date of Patent: August 22, 1978Assignees: Nippon Shinyaku Co., Ltd., Takara Shuzo Co., Ltd.Inventors: Osamu Tanabe, Akiro Obayashi, Teruya Nakamura, Osamu Suzuka, Masao Murayama, Hiromu Murai
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Patent number: 4103009Abstract: 2,4-Diamino-6-phenyl-s-triazine derivatives which are substituted in the 3-position of the phenyl ring and optionally further substituted in the 6-position demonstrate anti-ulcer and diuretic properties. A representative embodiment is 2,4-diamino-6-(3-trifluoromethylthiophenyl)-s-triazine.Type: GrantFiled: February 14, 1977Date of Patent: July 25, 1978Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Yoshiaki Aoyagi, Fusao Ueda, Masahiko Kitano, Shinichi Tada
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Patent number: 4100285Abstract: N-substituted trialkoxybenzyl piperazine derivatives expressed by the following general formula (I): ##STR1## where R represents a methyl or ethyl group, and Z represents a group selected from the group consisting of the following groups: isopropenyl group, cinnamyl group, morpholino ethyl group, diaminotriazine group, hydantoinbutyl group, ##STR2## where R represents the same as above, and n is an integer of 2 to 8, and ##STR3## where A represents a group selected from the group consisting of hydrogen, lower alkyl group, hydroxymethyl group, phenyl group, naphthyloxymethyl group and ##STR4## where Y represents a group selected from the group consisting of hydrogen, halogen, lower alkyl group, lower alkoxy group and hydroxy group.Type: GrantFiled: April 1, 1977Date of Patent: July 11, 1978Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Yoshiaki Aoyagi
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Patent number: 4098892Abstract: The mono-, bis- and trisnicotinoyl derivatives of melamine and the corresponding mono- and bisnicotinoyl derivatives of benzoguanamine demonstrate anti-ulcer and diuretic activity. A representative embodiment is 2-nicotinamido-4,6-diamino-s-triazine.Type: GrantFiled: February 18, 1977Date of Patent: July 4, 1978Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Kenji Sempuku, Yoshiaki Aoyagi, Fusao Ueda
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Patent number: 4094991Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: January 24, 1977Date of Patent: June 13, 1978Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4064252Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: June 4, 1976Date of Patent: December 20, 1977Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4031303Abstract: Steryl-6-0-palmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-6-0-palmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-6-0-sulfonyl-.beta.-D-glucoside with an alkali metal salt of palmitic acid.Type: GrantFiled: August 8, 1975Date of Patent: June 21, 1977Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Koji Kitaguchi, Tatsuo Suminokura, Akira Sano, Masahiro Kise, Masahiko Kitano, Toshio Tomita
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Patent number: 4024280Abstract: Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.Type: GrantFiled: May 12, 1975Date of Patent: May 17, 1977Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsuhide Saito, Tamiki Mori, Yasuo Yasutomi
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Patent number: 4009206Abstract: Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.Type: GrantFiled: August 13, 1975Date of Patent: February 22, 1977Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsahide Saito, Tamiki Mori, Yasuo Yasutomi
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Patent number: 3991186Abstract: Steryl-6-O-palnitoyl and -2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-.beta.-D-glucoside with a lower alkyl ester of palmitic acid in the presence of a basic catalyst.Type: GrantFiled: August 8, 1975Date of Patent: November 9, 1976Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Koji Kitaguchi, Tatsuo Suminokura, Akira Sano, Massahiro Kise, Masahiko Kitano, Toshio Tomita
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Patent number: 3966728Abstract: A series of novel benzoguanamine derivatives possessing a high anti-peptic ulcer activity with low toxicity has been prepared by the reaction of the corresponding dihalogenobenzonitriles with dicyandiamide or by the reaction of the corresponding carboxylic acids or functional derivatives thereof with biguanide.Type: GrantFiled: January 27, 1975Date of Patent: June 29, 1976Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Yoshiaki Aoyagi, Fusao Ueda, Masahiko Kitano, Satoshi Takata, Shinichi Tada