Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.

Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.

Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.

Abstract: A ring network system is a ring network system in which a plurality of nodes including a blocking node that blocks transfer of a predetermined frame are connected in a ring shape, and when, any one of the plurality of nodes detects a change in a link state with an adjacent node, the node detecting the change transmits a collision frame for inquiring a collision of a blocking node to a current blocking node, and in accordance with a response from the current blocking node, a determination is made which of the nodes is to be a new blocking node, and in a case where the link state with the adjacent node has a higher priority level of blocking than a link state between the current blocking nodes, the node having detected the change transmits a collision frame for inquiring a collision of the blocking node.

Abstract: A ring network system is a ring network system in which a plurality of nodes including a blocking node that blocks transfer of a predetermined frame are connected in a ring shape, and when, any one of the plurality of nodes detects a change in a link state with an adjacent node, the node detecting the change transmits a collision frame for inquiring a collision of a blocking node to a current blocking node, and in accordance with a response from the current blocking node, a determination is made which of the nodes is to be a new blocking node, and in a case where the link state with the adjacent node has a higher priority level of blocking than a link state between the current blocking nodes, the node having detected the change transmits a collision frame for inquiring a collision of the blocking node.

Abstract: A vibration isolator which is capable of stably opening and closing an orifice is provided at low manufacturing cost. A plunger for opening and closing an idle orifice is disposed in a manner that is slidably engaged with the inner wall surface of an orifice-forming member. A shaft portion extending downward is formed in the central portion of the plunger. A convex portion which is formed with a through-hole in which the shaft portion is slidably is provided on the bottom of the orifice-forming member so as to provide a bearing portion. The shaft portion of the plunger and the bearing portion of the orifice-forming member constitute a guide member for guiding the reciprocating motion of this plunger.

Abstract: A vibration isolator which is capable of stably opening and closing an orifice is provided at low manufacturing cost. A plunger for opening and closing an idle orifice is disposed in a manner that is slidably engaged with the inner wall surface of an orifice-forming member. A shaft portion extending downward is formed in the central portion of the plunger. A convex portion which is formed with a through-hole in which the shaft portion is slidably is provided on the bottom of the orifice-forming member so as to provide a bearing portion. The shaft portion of the plunger and the bearing portion of the orifice-forming member constitute a guide member for guiding the reciprocating motion of this plunger.

Abstract: A vibration isolator which is capable of stably opening and closing an orifice is provided at low manufacturing cost. A plunger for opening and closing an idle orifice is disposed in a manner that is slidably engaged with the inner wall surface of an orifice-forming member. A shaft portion extending downward is formed in the central portion of the plunger. A convex portion which is formed with a through-hole in which the shaft portion is slidably is provided on the bottom of the orifice-forming member so as to provide a bearing portion. The shaft portion of the plunger and the bearing portion of the orifice-forming member constitute a guide member for guiding the reciprocating motion of this plunger.

Abstract: In order to further improve driving stability, a dumper 10 mounted in a vehicle 14 in which a drive unit 11 having an engine 11a and a drive shaft 12 having tires 13 connected to respective end portions in the axial direction thereof, to which drive shaft torque is transferred from the engine 11a, are provided in a vehicle body frame 2, comprises: a connection part 16 for connecting the drive unit 11 with the vehicle body frame; a detection means 17 for detecting variation of torque transferred from the drive unit 11 to the drive shaft 12; and a controller 18 for controlling at least roll vibration of vibration behaviors of the drive unit 11 by operating the connection part 16 on the basis of a detection signal from the detection means 17.

Abstract: A vibration isolator which is capable of stably opening and closing an orifice is provided at low manufacturing cost. A plunger 236 for opening and closing an idle orifice 252 is disposed in a manner that is slidably engaged with the inner wall surface of an orifice-forming member 222. A shaft portion 262 extending downward is formed in the central portion of the plunger 236. A convex portion which is formed with a through-hole in which the shaft portion 262 is slidably is provided on the bottom of the orifice-forming member 222 so as to provide a bearing portion 266. The shaft portion 262 of the plunger 236 and the bearing portion 266 of the orifice-forming member 222 constitute a guide member for guiding the reciprocating motion of this plunger 236.

Abstract: A leg structure for a walking robot includes first and second input links rotatably attached to a robot body, a connecting link connected with the second input link at a point whose position can be varied, and an output link connected at one end with the distal end of the connecting link and connected at an intermediate point thereof with the first input link. When the leg structure is to be converted for use as an arm mechanism, the connecting link and the output link are passed beyond the singular point where they lie on a straight line, whereby the angle between the connecting link and the output link moves through the 180.degree. boundary between the leg and arm operating states and the driving mode of the output link is changed from low speed and high torque to high speed and low torque.