Patents by Inventor Hiroshi Fukase
Hiroshi Fukase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5175595Abstract: A non-contact measuring device which applies a scanning light moving parallel at a constant speed to an object to be measured and measures the shape of the object to be measured in accordance with the time for which the scanning light is shut off by the object to measured. To provide the scanning light, light generated from a source of light is allowed to enter through a lens a polygonal mirror rotating at a constant speed and the light reflected by the polygonal mirror is allowed to enter a collimator lens. And, it is necessary that the scanning light be focused at the position of the object to be measured. In the non-contact measuring device, a distance between the light source and lens can be adjusted by adjust means according to the position of the object to be measured and the light allowed to enter the collimator lens can be diverged or converged, so that the light can always be focused at the position of the object to be measured.Type: GrantFiled: July 19, 1991Date of Patent: December 29, 1992Assignee: Tokyo Seimitsu Co., Ltd.Inventor: Hiroshi Fukase
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Patent number: 5004838Abstract: Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X.sup.1 and X.sup.2 are both halogen; X.sup.1 is hydrogen and X.sup.2 is halogen; or X.sup.1 is --SQ.sup.1 and X.sup.2 is --SQ.sup.2 (each of Q.sup.1 and Q.sup.2 is lower alkyl or Q.sup.1 and Q.sup.2 may form lower alkylene), R.sup.1 is a protective group for hydroxyl and Y is .dbd.O, .dbd.N--Z (Z is hydroxyl which may be protected) or ##STR2## (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen.The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.Type: GrantFiled: September 29, 1989Date of Patent: April 2, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Hiroshi Fukase
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Patent number: 4898986Abstract: Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X.sup.1 and X.sup.2 are both halogen; X.sup.1 is hydrogen and X.sup.2 is halogen; or X.sup.1 is --SQ.sup.1 and X.sup.2 is --SQ.sup.2 (each of Q.sup.1 and Q.sup.2 is lower alkyl or Q.sup.1 and Q.sup.2 may form lower alkylene), R.sup.1 is a protective group for hydroxyl and Y is .dbd.O, .dbd.N--Z (Z is hydroxyl which may be protected) or ##STR2## (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen.The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.Type: GrantFiled: August 31, 1987Date of Patent: February 6, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Hiroshi Fukase
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Patent number: 4824943Abstract: The novel inosose derivatives ##STR1## wherein Y.sup.1 stands for hydroxyl group and Y.sup.2 stands for hydrogen atom, or Y.sup.1 and Y.sup.2 are joined to form a bond between carbon and carbon atoms, and R.sup.1 and is a protective group for hydroxyl group, are useful as a starting material for producing valienamine, valiolamine and their N-substituted derivatives.Type: GrantFiled: March 4, 1987Date of Patent: April 25, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Hiroshi Fukase
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Patent number: 4803303Abstract: A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.Type: GrantFiled: April 17, 1987Date of Patent: February 7, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
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Patent number: 4777294Abstract: A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.Type: GrantFiled: April 17, 1987Date of Patent: October 11, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
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Patent number: 4701559Abstract: A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.Type: GrantFiled: December 28, 1981Date of Patent: October 20, 1987Assignee: Takeda Chemical Industries, Inc.Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
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Patent number: 4595678Abstract: A compound of the general formula: ##STR1## wherein A is hydrogen or a hydroxyl group; B is (1) a group of the formula; ##STR2## (2) a group of the formula; ##STR3## or (3) a group of the formula; ##STR4## or a pharmaceutically acceptable salt thereof is novel and possesses excellent inhibitory activity against .alpha.-glucoside hydrolase and are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.Type: GrantFiled: March 15, 1983Date of Patent: June 17, 1986Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
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Patent number: 4486602Abstract: A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group; or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.Type: GrantFiled: September 29, 1981Date of Patent: December 4, 1984Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
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Patent number: 4465844Abstract: The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.Type: GrantFiled: August 23, 1983Date of Patent: August 14, 1984Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Hiroshi Fukase, Eiji Higashide
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Patent number: 4446319Abstract: Novel aminocyclitols, namely the compounds of the formula ##STR1## wherein X is hydroxyl group, a halogen or an acyloxy group; Y is hydrogen or a halogen; and OR.sup.1 is an optionally protected hydroxyl group; and their production.These aminocyclitols are important intermediates for preparing valiolamine having .alpha.-glucosidase inhibitory activity.Type: GrantFiled: April 26, 1982Date of Patent: May 1, 1984Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Hiroshi Fukase
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Patent number: 4436918Abstract: The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.Type: GrantFiled: January 18, 1982Date of Patent: March 13, 1984Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoshi Horii, Hiroshi Fukase, Eiji Higashide
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Patent number: 4017485Abstract: A novel antibiotic C-2801-X represented by the formula ##STR1## is produced by cultivating a microorganism of the genus Streptomyces. The compound is useful in the treatment of mammals, including human beings, suffering from urinary tract infections, respiratory tract infections, colitis, septicema, purulent diseases, etc.Type: GrantFiled: September 11, 1974Date of Patent: April 12, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Toru Hasegawa, Kazunori Hatano, Hiroshi Fukase, Hidesuke Iwasaki