Abstract: The present invention is directed to the combination therapy of cancer with a BRAF inhibitor and a MEK inhibitor, as well as uses and pharmaceutical compositions thereof.

Abstract: A data storage device is disclosed comprising a head actuated over a disk comprising servo data for defining a plurality of data tracks, wherein each data track comprises a plurality of data segments. First data is written to data segments of a first data track, and second data is written to data segments of a second data track. After writing the second data, the first data is read at multiple off-track offsets of the first data track to measure an average off-track read capability (OTRC) of the first data track. A cross-track profile is generated for a first data segment of the first data track, and at least part of the cross-track profile is correlated with the measured average OTRC.

Abstract: A data storage device is disclosed comprising a head actuated over a disk comprising servo data for defining a plurality of data tracks, wherein each data track comprises a plurality of data segments. First data is written to data segments of a first data track, and second data is written to data segments of a second data track. After writing the second data, the first data is read at multiple off-track offsets of the first data track to measure an average off-track read capability (OTRC) of the first data track. A cross-track profile is generated for a first data segment of the first data track, and at least part of the cross-track profile is correlated with the measured average OTRC.

Abstract: A data storage device is disclosed comprising a head actuated over a disk comprising servo data for defining a plurality of data tracks, wherein each data track comprises a plurality of data segments. First data is written to a first data segment of a first data track, and second data is written to a second data segment of a second data track. After writing the second data, a quality metric is measured for at least two off-track offsets of the first data segment. A track pitch is estimated between the first data segment and the second data segment based on the quality metrics, and a track trajectory is generated for the second data segment based on the estimated track pitch. Third data is written to the second data segment based on the track trajectory.

Abstract: A data storage device is disclosed comprising a head actuated over a disk comprising servo data for defining a plurality of data tracks. A plurality of zones are defined for the disk, wherein each zone comprises a plurality of the data tracks. Position error signal (PES) repeatable runout (RRO) values are generated based on the servo data in a first zone, and data sector squeeze RRO values are generated based on data segments in the first zone. A first data track format for the first zone is generated based on the PES RRO values, and a second data track format is generated for the first zone based on the data sector squeeze RRO values.

Abstract: Disclosed is a tile unit (10) that includes a resin net (20), a plurality of tiles (30) disposed on a front side of the resin net, and a magnet sheet (40) disposed on a back side of the resin net, with the tiles being bonded and fixed to the magnet sheet with the resin net interposed therebetween.

Abstract: Disclosed is a tile unit (10) that includes a resin net (20), a plurality of tiles (30) disposed on a front side of the resin net, and a magnet sheet (40) disposed on a back side of the resin net, with the tiles being bonded and fixed to the magnet sheet with the resin net interposed therebetween.

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2?-deoxyuridine (fdU or foUdR) or a 5-formyl-2?-deoxyuridine derivative, optionally in combination with 5-hydroxy-2?-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2?-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2?-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2?-deoxyuridine (fdU or foUdR) or a 5-formyl-2?-deoxyuridine derivative, optionally in combination with 5-hydroxy-2?-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2?-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2?-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.

Abstract: Systems and techniques for writing data to a Shingled Magnetic Recording (SMR) magnetic data storage device. At least one processor may determine whether the distance between a first data track and a second data track is less than a threshold distance. If the distance is less than a threshold distance, the at least one processor may cause a write head to refrain from writing to the sector of the second data track. The at least one processor may cause data from the first data track to be copied to another storage location and write data to the sector of the second data track.

Abstract: The present invention achieves higher precision and lower power consumption by reducing semiconductor chip occupation area. A semiconductor integrated circuit which can be mounted on an optical disk device has: a wobble signal generating circuit capable of receiving first, second, third, and fourth light reception output signals A, B, C, and D of a light receiving element in an optical pickup and detecting a wobble in a recordable disk; a differential phase detection signal (DPD) generating circuit for tracking an unrecordable disk; and two A/D converters and an arithmetic circuit.

Abstract: The present invention achieves higher precision and lower power consumption by reducing semiconductor chip occupation area. A semiconductor integrated circuit which can be mounted on an optical disk device has: a wobble signal generating circuit capable of receiving first, second, third, and fourth light reception output signals A, B, C, and D of a light receiving element in an optical pickup and detecting a wobble in a recordable disk; a differential phase detection signal (DPD) generating circuit for tracking an unrecordable disk; and two A/D converters and an arithmetic circuit.

Abstract: A magnetic recording medium having excellent stability of recorded magnetic signals and capable of recording magnetic signals by a thermally assisted magnetic recording system in which a magnetic recording layer of the magnetic recording medium contains ferromagnetic crystal grains of a Co—Ni—Pt alloy with a Pt content of 44 at % or more and 55 at % or less and with an atom content ratio: Ni/(Co+Ni) of 0.64 or more and 0.8 or less. The magnetic recording medium has extremely excellent stability of recorded magnetic signals since the Co—Ni—Pt alloy constituting the magnetic recording layer has an extremely high anisotropy field at a normal temperature. Further, the magnetic recording medium can perform signal recording based on the thermally assisted magnetic recording system since the Co—Ni—Pt alloy constituting the magnetic recording layer has a Curie point within an appropriate temperature range.

Abstract: There is provided a semiconductor device capable of supplying an analog input signal higher than or equal to an operating power supply voltage. An electrostatic discharge protection circuit corresponding to the analog input signal is provided for an external terminal that is supplied with an analog input signal generated with a first power supply voltage. A voltage divider resistor divides the analog input signal passing through the electrostatic discharge protection circuit into a voltage corresponding to a second power supply voltage lower that the first power supply voltage. An input circuit operating on the second power supply voltage receives the analog input signal divided by the voltage divider resistor to form an internal analog signal. There are provided first and second unidirectional elements. The first unidirectional element passes current from the input circuit's input terminal to the second power supply voltage.

Abstract: An output of a magnetic head changes depending on the environmental temperature of a magnetic disk. In particular, under cold temperature conditions, an output of the head largely decreases mainly due to an increase in coercivity of a magnetic recording medium, which degrades an error rate. In one embodiment of the invention, sense-current optimization processing of a magnetic disk drive comprises the steps of: measuring the environmental temperature; and after a sense-current value which is set from the viewpoint of the reliability of the magnetic head is defined as an upper limit, finding out a sense current Is that can achieve the best error rate (BER) at the temperature. While changing a value of the sense current Is inside the magnetic disk drive, an error rate is measured. Then, a sense current Is_opt at which the best error rate properties are achieved is selected as a new set value.

Abstract: In the present invention, by making the width of the write element larger than the track pitch and securing a write magnetic field strong enough to reverse the magnetization of the magnetic layer, and further by writing while shifting a write head comprising the write element, a magnetic disk drive, of which the track width is narrower than the write element width, and the storage capacity is large, is realized.

Abstract: Embodiments of the present invention help to compute controlling quantity to make the spacing between a floating head slider and a recording medium optimum without damaging the floating head slider and the recording medium by detecting the floating head slider's contact with the recording medium with high sensitivity.

Abstract: Embodiments of the present invention provide a process that monitors a magnetic playback signal while gradually increasing an electricity supply amount for a heater to thereby determine contact between a magnetic head slider and a magnetic disk medium. According to one embodiment, after components for configuring a magnetic recording/playback portion are assembled into a housing, magnetic information is played back on a specific track of a magnetic disk medium by using a playback element while gradually increasing an electricity supply amount for a heater of a magnetic head slider. An amplitude of a playback signal is measured at a plurality of portions along a circumferential direction of the track. Contact between the magnetic head slider and the magnetic disk medium is detected in accordance with an increase in variation in the measured amplitude.

Abstract: A write head's material having a great thermal expansion coefficient expands due to Joule heat resulting from a write current and a temperature rise dependent on high-frequency core loss, thereby causing the head's flying surface to protrude toward a magnetic disk. This phenomenon is called TPR (thermal protrusion). It is essential that the flying height be accurately determined and managed in consideration of TPR. A magnetic disk drive for actual use or a magnetic disk drive that is in a testing process but similar to the one for actual use is used to measure TPR amount changes resulting from a write operation, store the resulting measured data in a memory or on the magnetic disk, and perform flying height management with the stored measured data. Further, flying height management is performed as needed in conjunction with a SMART function. The present invention makes it possible to perform high-reliability flying height management.

Abstract: There is provided a semiconductor device capable of supplying an analog input signal higher than or equal to an operating power supply voltage. An electrostatic discharge protection circuit corresponding to the analog input signal is provided for an external terminal that is supplied with an analog input signal generated with a first power supply voltage. A voltage divider resistor divides the analog input signal passing through the electrostatic discharge protection circuit into a voltage corresponding to a second power supply voltage lower that the first power supply voltage. An input circuit operating on the second power supply voltage receives the analog input signal divided by the voltage divider resistor to form an internal analog signal. There are provided first and second unidirectional elements. The first unidirectional element passes current from the input circuit's input terminal to the second power supply voltage.