Patents by Inventor Hiroshi Nagano

Hiroshi Nagano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11407787
    Abstract: The present application discloses a crystal of oxidized glutathione dication salt and a method of producing the same.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: August 9, 2022
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Akihiro Fujimoto, Kazunari Fukumoto, Hiroshi Nagano
  • Patent number: 11365170
    Abstract: An object of the present invention is to provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity, and a method for producing the same. The present invention can provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity by drying a methanol solvate crystal of eucomic acid.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: June 21, 2022
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Yuta Yamaguchi, Hiroshi Nagano
  • Patent number: 11233433
    Abstract: A virtual circle included in the through-hole as viewed from the axial direction is assumed in the through-hole. An inner peripheral surface of the through-hole includes a first side that is located on a radial inside with respect to the virtual circle and extends along the circumferential direction, a second side that is located on one side in the circumferential direction with respect to the virtual circle and extends along the radial direction, and a third side that is located on another side in the circumferential direction with respect to the virtual circle and extends along the radial direction. The second side and the third side contact with the virtual circle. The first side extends linearly or extends radially outward in a curved manner when viewed from the axial direction.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: January 25, 2022
    Assignee: NIDEC CORPORATION
    Inventors: Tomoki Iga, Hiroshi Nagano
  • Patent number: 11186610
    Abstract: The present invention relates to a crystal of glutathione trisulfide dihydrate and a method for producing the same. According to the present invention, for example, the crystal can be provided by concentrating an aqueous solution in which glutathione trisulfide is dissolved and collecting the precipitated crystal of glutathione trisulfide dihydrate. In addition, the present invention relates to a simple method for producing polysulfide in an aqueous solvent using thiosulfate without using hydrogen sulfide, by stirring an aqueous solution in which a compound having a thiol group or a disulfide bond and thiosulfate are dissolved or by leaving the aqueous solution to stand.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: November 30, 2021
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Akihiro Fujimoto, Hiroshi Nagano
  • Publication number: 20210261493
    Abstract: An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.
    Type: Application
    Filed: March 3, 2021
    Publication date: August 26, 2021
    Applicants: KYOWA HAKKO BIO CO., LTD., OTSUKA PHARMACEUTICAL FACTORY, INC.
    Inventors: Tomoya YOKOI, Hiroshi NAGANO, Takayuki SHIMIZU
  • Patent number: 11098007
    Abstract: An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: August 24, 2021
    Assignees: KYOWA HAKKO BIO CO., LTD., OTSUKA PHARMACEUTICAL FACTORY, INC.
    Inventors: Tomoya Yokoi, Hiroshi Nagano, Takayuki Shimizu
  • Publication number: 20210221764
    Abstract: An object of the present invention is to provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity, and a method for producing the same. The present invention can provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity by drying a methanol solvate crystal of eucomic acid.
    Type: Application
    Filed: July 12, 2019
    Publication date: July 22, 2021
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Yuta YAMAGUCHI, Hiroshi NAGANO
  • Patent number: 11008355
    Abstract: An object of the present invention is to provide a crystal of 3?-sialyllactose (hereinafter, referred to as 3SL), which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a process for producing the same. The present invention relates to a 3SL sodium salt n-hydrate (wherein n represents any number of 0 to 9, and when n is 0, it is referred to as 3SL sodium salt anhydrate) and a process for producing the same.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: May 18, 2021
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Tomoya Yokoi, Hiroshi Nagano, Kikue Mase, Masahiro Abe
  • Patent number: 10858393
    Abstract: According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: December 8, 2020
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari Fukumoto, Maya Iguchi, Hiroshi Nagano
  • Publication number: 20200369721
    Abstract: The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 ?m or more.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 26, 2020
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari FUKUMOTO, Maya IGUCHI, Hiroshi NAGANO
  • Publication number: 20200350793
    Abstract: A virtual circle included in the through-hole as viewed from the axial direction is assumed in the through-hole. An inner peripheral surface of the through-hole includes a first side that is located on a radial inside with respect to the virtual circle and extends along the circumferential direction, a second side that is located on one side in the circumferential direction with respect to the virtual circle and extends along the radial direction, and a third side that is located on another side in the circumferential direction with respect to the virtual circle and extends along the radial direction. The second side and the third side contact with the virtual circle. The first side extends linearly or extends radially outward in a curved manner when viewed from the axial direction.
    Type: Application
    Filed: October 31, 2018
    Publication date: November 5, 2020
    Inventors: Tomoki IGA, Hiroshi NAGANO
  • Patent number: 10774109
    Abstract: The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 ?m or more.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: September 15, 2020
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari Fukumoto, Maya Iguchi, Hiroshi Nagano
  • Patent number: 10745432
    Abstract: An object of the present invention is to provide a crystal of 6?-sialyllactose (hereinafter, referred to as 6SL) sodium salt, which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a production process thereof. The present invention relates to a crystal of 6SL sodium salt and a process for producing the crystal.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: August 18, 2020
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Masahiro Abe, Tomoya Yokoi, Sotaro Sanpei, Kazunari Fukumoto, Hiroshi Nagano
  • Patent number: 10647653
    Abstract: The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in solubility and easy to handle, and a process for producing the crystal. A crystal of a monovalent cation salt of HMB is precipitated in an aqueous HMB solution containing a monovalent cation-containing compound and having a pH of 4.0 to 9.0, and the crystal of a monovalent cation salt of HMB is thereafter collected from the aqueous solution.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 12, 2020
    Assignees: KYOWA HAKKO BIO CO., LTD., OTSUKA PHARMACEUTICAL FACTORY, INC.
    Inventors: Tomoya Yokoi, Hiroshi Nagano, Takayuki Shimizu
  • Patent number: 10640532
    Abstract: The present invention provides a crystal of reduced glutathione that is stable, and is easy to process, and a method for producing the crystal. According to the present invention, a crystal of a metal salt of reduced glutathione is produced by suspending an amorphous solid of a metal salt of reduced glutathione in a hydrophobic organic solvent, and adding water to the resulting suspension to precipitate a crystal of a metal salt of reduced glutathione.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 5, 2020
    Assignees: University Public Corporation Osaka, Kyowa Hakko Bio Co., Ltd.
    Inventors: Hiroshi Ooshima, Koichi Igarashi, Hiroshi Nagano, Akihiro Fujimoto, Kenta Fukumoto, Kazunari Fukumoto, Tomoya Yokoi
  • Publication number: 20200095279
    Abstract: The present application discloses a crystal of oxidized glutathione dication salt and a method of producing the same.
    Type: Application
    Filed: June 6, 2018
    Publication date: March 26, 2020
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Akihiro FUJIMOTO, Kazunari FUKUMOTO, Hiroshi NAGANO
  • Publication number: 20200079818
    Abstract: The present invention relates to a crystal of glutathione trisulfide dihydrate and a method for producing the same. According to the present invention, for example, the crystal can be provided by concentrating an aqueous solution in which glutathione trisulfide is dissolved and collecting the precipitated crystal of glutathione trisulfide dihydrate. In addition, the present invention relates to a simple method for producing polysulfide in an aqueous solvent using thiosulfate without using hydrogen sulfide, by stirring an aqueous solution in which a compound having a thiol group or a disulfide bond and thiosulfate are dissolved or by leaving the aqueous solution to stand.
    Type: Application
    Filed: December 20, 2017
    Publication date: March 12, 2020
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Akihiro FUJIMOTO, Hiroshi NAGANO
  • Patent number: 10581331
    Abstract: To measure with ease an input voltage from an external power source and notify the user of the input voltage, a power source apparatus comprising a power source voltage input terminal, an insulating transformer, a power source control device, and a communication unit is provided. The power source voltage input terminal is connected to an external battery. The insulating transformer has a primary coil that is connected to the power source voltage input terminal. The power source control device is connected to the power source voltage input terminal and measures the input voltage to the power source voltage input terminal. The communication unit transmits the voltage value measured by a microcomputer to the secondary side of the insulating transformer.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: March 3, 2020
    Assignee: Furuno Electric Co., Ltd.
    Inventors: Youhei Kinoshita, Hiroshi Yoshii, Hiroshi Nagano, Wenhai Liu
  • Patent number: 10407463
    Abstract: The invention provides a method of efficiently and stably producing ?-form crystal of reduced glutathione, and a preservation method thereof. According to the invention, development of ?-form crystal and/or transition to ?-form crystal of reduced glutathione are suppressed by the coexistence of at least one kind of compound selected from the group of aliphatic amino acid, sulfur-containing amino acid, aromatic amino acid, an analogous compound and dipeptide, as a habit modifier, during production and preservation of an aqueous solution or ?-form crystal of reduced glutathione.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 10, 2019
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Maya Iguchi, Kazunari Fukumoto, Hiroshi Nagano
  • Publication number: 20190210958
    Abstract: An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.
    Type: Application
    Filed: June 23, 2017
    Publication date: July 11, 2019
    Applicants: KYOWA HAKKO BIO CO., LTD., OTSUKA PHARMACEUTICAL FACTORY, INC.
    Inventors: Tomoya YOKOI, Hiroshi NAGANO, Takayuki SHIMIZU