Patents by Inventor Hirotake Takai

Hirotake Takai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detection of liver cancer cell using anti-glypican-3 antibody
    Patent number: 8663929
    Abstract: The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in the detection of glypican 3 antigen expression in liver cancer tissues to thereby detect the difference in the expression level or expression pattern of the glypican 3 antigen by immunohistochemical staining method. This enables samples, which has been determined by the conventional HIER method as highly expressing glypican 3, to be graded according to the expression level of glypican 3.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: March 4, 2014
    Assignees: University of Miyazaki, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hiroaki Kataoka, Hirotake Takai, Atsuhiko Kato, Masami Suzuki, Masamichi Sugimoto
  • METHOD FOR DETECTION OF LIVER CANCER CELL USING ANTI-GLYPICAN-3 ANTIBODY
    Publication number: 20110091907
    Abstract: The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in the detection of glypican 3 antigen expression in liver cancer tissues to thereby detect the difference in the expression level or expression pattern of the glypican 3 antigen by immunohistochemical staining method. This enables samples, which has been determined by the conventional HIER method as highly expressing glypican 3, to be graded according to the expression level of glypican 3.
    Type: Application
    Filed: March 16, 2009
    Publication date: April 21, 2011
    Applicants: University of Miyazaki, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hiroaki Kataoka, Hirotake Takai, Atsuhiko Kato, Masami Suzuki, Masamichi Sugimoto