Abstract: The present invention provides solid preparations having two or more colors or a pattern of two or more different colors which can solve the problems of the prior art including the complexity of production processes and the low strength of solid preparations. Specifically, an object of the present invention is to provide solid preparations coated with a continuous film coating layer having two or more different colors or a pattern of two or more different colors which preparations are obtained by irradiating a part of the film coating layer containing one or more colorants with light, a process for the preparation of such solid preparations, and a film coating agent therefor.

Abstract: Provided is an enteric-coated preparation comprising an enteric coating material capable of delivering a drug to a site within the small intestine in a site-specific manner. More specifically, provided is an enteric-coated preparation for delivering a drug to a site within the small intestine in a site-specific manner, comprising a drug-containing preparation and an enteric coating material which covers the preparation, wherein, in Dissolution Test as specified in the Japanese Pharmacopoeia Fourteenth Edition, no dissolution of the drug is observed in the Japanese Pharmacopoeia first fluid (pH 1.2) while dissolution of the drug is observed in the Japanese Pharmacopoeia second liquid (pH 6.8) 20 minutes or later from start of the Dissolution Test. The enteric coating material is preferably selected from the group consisting of hydroxypropylmethyl cellulose acetate succinate, hydroxypropylmethyl cellulose phthalate, methacrylic acid copolymer and carboxymethylethyl cellulose.

Abstract: The present invention provides solid preparations having two or more colors or a pattern of two or more different colors which can solve the problems of the prior art including the complexity of production processes and the low strength of solid preparations. Specifically, an object of the present invention is to provide solid preparations coated with a continuous film coating layer having two or more different colors or a pattern of two or more different colors which preparations are obtained by irradiating a part of the film coating layer containing one or more colorants with light, a process for the preparation of such solid preparations, and a film coating agent therefor.

Abstract: An aqueous coating composition comprising hydroxypropyl methyl cellulose trimellitate typically having a mean particle size of up to 10 &mgr;m and a plasticizer is applied to a solid pharmaceutical preparation to form a coating film having acid resistance and solubility at about pH 4. The coated preparation has an improved bioavailability.

Abstract: A solid preparation characteristically containing for a binder methyl cellulose whose MeO content is 27.5-31.5 wt % and whose 2 wt % aqueous solution has a viscosity of 2-12 cP at 20° C. The present invention can provide a solid preparation which has an adequate hardness and at the same time disintegrates quickly for easy absorption.

Abstract: An enteric preparation prepared by coating a solid dosage form with a fine powder enteric coating agent while spraying a liquid plasticizer.

Abstract: A method of manufacturing a solid preparation coated with a non-solvent coating which is prepared by feeding a polymeric powder directly as coating agent while continuously spraying a solid medicine with an atomized mixture of a liquid substance, which has a contact angle against the polymer coating agent of 10 degrees or less, and a plasticizer. A method of manufacturing a dry-coated solid preparation in which a solid preparation, coated with a non-solvent coating, is treated by adding or spraying an atomized water or an aqueous solution of a water soluble substance in the amount of 1-10 wt % of the solid preparation to wet said "coating layer" followed by drying.

Abstract: The present invention provides a base for coating a solid enteric pharmaceutical preparation whose dissolution pH ranges from 3 to 4. The coating base is a cellulose acetate maleate which is prepared by substituting a water-soluble cellulose derivative with 0.25 to 0.5 acetyl group and 0.35 to 0.6 maleyl group per glucose ring of the cellulose derivative. The cellulose acetate maleate has a dissolution pH ranging from 3 to 4.

Abstract: A cellulosic enteric base is dissolved in an organic solvent capable of being admixed with water in any rate or a mixed solvent of the organic solvent and water to give a polymer solution, followed by mixing the polymer solution with water, then removing the organic solvent to give a concentrate; adding an anionic surfactant to the concentrate and then drying to give polymer powder. The polymer powder is introduced into water to give an emulsion containing polymer particles having an average particle size of not more than 1 .mu.m and the emulsion is dispersed in water containing a plasticizer to give a coating liquid. A drug is coated with the coating liquid to give a solid enteric pharmaceutical preparation.

Abstract: A coating base for solid enteric pharmaceutical preparations having a dissolution pH ranging from 3.5 to 4.5 essentially consisting of hydroxypropylmethyl cellulose trimellitate obtained by substituting water-soluble hydroxypropylmethyl cellulose having 1.1 to 1.6 methoxy group per glucose ring thereof with 0.2 to 1.0 trimellitate group per glucose ring, or obtained by substituting water-soluble hydroxypropylmethyl cellulose having 1.7 to 2.1 methoxy groups per glucose ring thereof with 0.2 to 0.5 trimellitate group per glucose ring. The coating base can be dissolved at the upper portion of the small intestine without delay and a solid enteric pharmaceutical preparation provided with a coating film of the base can completely release the drug included therein before the preparation passes through the small intestine. Therefore, the base can ensure a high pharmacological action of the drug.

Abstract: A plasticizer which is in a solid state at ordinary temperature and a pigment are added to and mixed with a coating base which consists of particulate hydroxypropyl methyl cellulose and/or methyl cellulose having an average particle size ranging from 200 to 1000 .mu.m and whose content of particles having a particle size of not more than 75 .mu.m is not more than 30% by weight. The resulting mixture is heated to a temperature of not less than the solidification point of the plasticizer to give a rapidly soluble coating composition. If the plasticizer is in a liquid state at ordinary temperature, a powdery pigment is added to and mixed with the foregoing coating base while spraying the liquid plasticizer on the resulting mixture to give a rapidly soluble coating composition.

Abstract: A method permits the easy preparation of an aqueous emulsion for coating solid pharmaceutical preparations through emulsification in water without addition of additives such as emulsifying agents, polymerization initiators, chain transfer agents, salts and plasticizers. A cellulosic polymer is dissolved in an organic solvent miscible in water in any rate or a mixed solvent comprising the organic solvent and water to give a polymer solution. The polymer solution is mixed with water to disperse the solution in water and thereafter the organic solvent is removed to form an aqueous emulsion for coating solid pharmaceutical preparations. If ethyl cellulose is used as a coating base, ethyl cellulose is first dissolved in a non-hydrophilic solvent to give a non-hydrophilic solution thereof.

Abstract: A method for preparing an aqueous emulsion for coating solid pharmaceutical preparations comprises the steps of dissolving a cellulosic polymer in a mixed solvent of water and an organic solvent capable of being admixed with water in any rate to give a polymer solution, self-emulsifying the polymer solution by mixing with water and then concentrating the resulting emulsified stock solution. The concentration is carried out by removing a part of the liquid components while passing it through a membrane for ultrafiltration till the polymer concentration of the resulting emulsion reaches a level of not less than 7% by weight.

Abstract: The present invention provides a powdery starting material for preparing a drug-coating solution, which has high safety as a drug component and is very rapidly dissolved in room temperature water upon preparation of a coating solution. The powdery starting material for preparing a drug-coating solution comprises hydroxypropylmethyl cellulose and/or methyl cellulose particles having an average particle size ranging from 200 to 1000 .mu.m and whose content of particles having a particle size of 75 .mu.m or smaller is not more than 30% by weight. More preferably, the viscosity of a 2% by weight aqueous solution of the powdery starting material as determined at room temperature ranges from 2 to 60 cP and preferably 2 to 20 cP.

Abstract: Film coated pharmaceutical preparations, which are prepared by overlaying to the outer surface of pharmaceutical preparations, a coating layer comprising at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethylethyl cellulose and cellulose acetate phthalate, are irradiated with light including ultraviolet rays. Whereby film coated pharmaceutical preparations, the coating layer surface of which are excellent in whiteness, are prepared. Moreover, as a content of a white pigment in corporated into the coating layer of such preparations may be reduced, the stability of such preparations can be enhanced without impairing the strength of the coating layer.

Abstract: Solid medicament forms, such as granules, beads, tablets, are first coated with a hot aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, and then subjected to a wax treatment with heating to form a masking layer of the wax. Different from the coating film of a cellulose ether formed by using an aqueous or organic solution of the cellulose ether, the coating film formed by using the aqueous dispersion of the cellulose ether has a porous structure so that the amount of the wax deposited in the wax treatment is much larger than in the prior art methods to exhibit a high effect of masking the bitterness of the ingredient contained in the medicament form.

Abstract: Instead of using a uniform aqueous solution of a water-soluble cellulose ether as a coating liquid of solid medicament forms, e.g., granules and tablets, to form a film-forming layer, an aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, is used as a coating liquid at a temperature higher than the solubilization temperature, i.e. the critical point of the solubility behavior, followed by plasticization of the cellulose ether particles with water to cause fusion thereof. The coating liquid is freed from the limitation by the flowability even when the content of the cellulose ether is much higher than in the conventional solution-type coating liquid.