Abstract: The present invention provides a target substance transfer method, a crystal production method, a composition production method, and a target substance transfer device, which allow the concentration of a target substance to be increased easily and effectively. The target substance transfer method is a method for transferring a target substance 103 from a first phase 101 that is a liquid or solid phase containing the target substance 103 to a second phase 102 including: a phase approximation step of bringing the first phase 101 and the second phase 102 into close proximity; and a bubble collapse step of forming bubbles in the vicinity of a boundary between the first phase 101 and the second phase 102 and then causing the bubbles to collapse.

Abstract: Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source; a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source; a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 ?m band; and a method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.

Abstract: The present invention provides a target substance transfer method, a crystal production method, a composition production method, and a target substance transfer device, which allow the concentration of a target substance to be increased easily and effectively. The target substance transfer method is a method for transferring a target substance 103 from a first phase 101 that is a liquid or solid phase containing the target substance 103 to a second phase 102 including: a phase approximation step of bringing the first phase 101 and the second phase 102 into close proximity; and a bubble collapse step of forming bubbles in the vicinity of a boundary between the first phase 101 and the second phase 102 and then causing the bubbles to collapse.

Abstract: Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source; a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source; a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 ?m band; and a method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.

Abstract: A method for manufacturing a GRIN lens includes the steps of forming a wet gel provided with a concentration distribution having a different concentration of a refractive index distribution imparting metal that differs in concentration in a radial direction, drying the wet gel to form a dry gel having a bulk specific gravity ? (g/cm3), sintering the dry gel to form a GRIN lens base material and stretching the GRIN lens base material while heating. The method is characterized in that, in the step of sintering the dry gel, partial pressures of oxygen during sintering at 800° C. or higher are 10?1 Pa or lower and also the relation between a rate of temperature increase v (° C./hr) and a bulk density ? of the dry gel during sintering at 1,000 to 1,150° C. is defined by v?105*EXP (?12?). As a result of this, the GRIN lens, which has a large numerical aperture and a small diameter, can stably and easily be manufactured.

Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.

Abstract: An optical fiber coupling part that reduces the difficulty in adjusting cores, minimizes coupling loss, and prevents optical characteristics from deteriorating. An optical fiber is fused to one end of a GRIN lens which includes a quartz glass containing one or more refractive index regulating substances selected from Sb2O3, Ta2O5, TiO2 or ZrO2. Optical characteristics are not deteriorated because an adhesive is not used, and self-alignment effects facilitate adjustment of the cores of the GRIN lens and the optical fiber. Furthemore, coupling loss can be minimized by setting a refractive index distribution constant g of the GRIN lens within an appropriate range.

Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.

Abstract: The object of the present invention is to provide a semiconductor laser module capable of reducing the burdens for the arrangement of the optical system than the conventional one. The semiconductor laser module comprises: a semiconductor laser 1 for emitting, as a transmitted light, a light with a wavelength within a certain communication wavelength band such as, for example, 1.3 .mu.

Abstract: An optical fiber coupling part that reduces the difficulty in adjusting cores, minimizes coupling loss, and prevents optical characteristics from deteriorating. An optical fiber is fused to one end of a GRIN lens which includes a quartz glass containing one or more refractive index regulating substances selected from Sb2O3, Ta2O5, TiO2 or ZrO2. Optical characteristics are not deteriorated because an adhesive is not used, and self-alignment effects facilitate adjustment of the cores of the GRIN lens and the optical fiber. Furthermore, coupling loss can be minimized by setting a refractive index distribution constant g of the GRIN lens within an appropriate range.

Abstract: The object of the present invention is to provide a semiconductor laser module capable of reducing the burdens for the arrangement of the optical system than the conventional one. The semiconductor laser module comprises: a semiconductor laser 1 for emitting, as a transmitted light, a light with a wavelength within a certain communication wavelength band such as, for example, 1.3 .mu.

Abstract: A fiber optic collimator system, a fiber optic collimator array, and a fiber optic collimator array system, which can reduce difficulty in an alignment process, minimize a coupling loss, and prevent the optical characteristics from deteriorating. An optical fiber is fused to one end of a GRIN lens made of quartz glass containing one or more selected from Sb2O3, Ta2O5, TiO2 and ZrO2 as a refractive index regulating substance, to form an optical fiber with a GRIN lens. Since an adhesive is not used, the core alignment of the GRIN lens and the optical fiber can be facilitated by a self alignment effect without deteriorating the optical characteristics. Moreover, the coupling loss is remarkably reduced by appropriately setting a refractive index distribution constant g of the GRIN lens.

Abstract: An optical fiber coupling part capable of reducing coupling loss while maintaining a large operating distance, and having a good module assembling property. AT least one GRIN lens having numerical aperture NA that is larger than numerical aperture NAs of a light-emitting source (such as a semiconductor laser) is fusion-spliced with one end of the optical fiber. All lights emitted from the light-emitting source can enter the GRIN lens, and the loss of the light can thereby be reduced. In addition, a second GRIN lens having numerical aperture NA2 is fusion-spliced with one end of the optical fiber having numerical aperture NAf, and further a first GRIN lens having numerical aperture NA1, which is larger than numerical aperture NA2, is fusion-spliced with the other end of the second GRIN lens. Thereby, the light emitted from the light-emitting source can efficiently enter the optical fiber, and loss of the light can thereby be reduced. In this case, the formula expressed by NAf?NA2<NAs?NA1 is desirable.

Abstract: To provide a wavelength-selection optical switch able to select a light with a certain wavelength and an optical add/drop multiplexer using the same. An optical switch comprising: a silicon substrate; a glass substrate arranged to face a surface of the silicon substrate and having a transparent electrode layer in its opposing surface; a light diffraction reflection layer aligned on a surface of the silicon substrate; a liquid crystal layer aligned between the light diffraction reflection layer and the transparent electrode layer; a silicon substrate electrical terminal extracted from a rear surface of the silicon substrate; and a means for applying voltage between the transparent electrode layer and the silicon substrate electrical terminal; wherein selection of wavelength of light diffracted and reflected by the light diffraction reflection layer is possible by controlling the refraction index of the liquid crystal layer through the voltage.

Abstract: To provide with a wavelength-selection optical switch able to select a light with a certain wavelength and an optical add/drop multiplexer using the same. An optical switch comprising: a silicon substrate; a glass substrate arranged to face a surface of the silicon substrate and having a transparent electrode layer in its opposing surface; a light diffraction reflection layer aligned on a surface of the silicon substrate; a liquid crystal layer aligned between the light diffraction reflection layer and the transparent electrode layer; a silicon substrate electrical terminal extracted from a rear surface of the silicon substrate; and a means for applying voltage between the transparent electrode layer and the silicon substrate electrical terminal; wherein selection of wavelength of light diffracted and reflected by the light diffraction reflection layer is possible by controlling the refraction index of the liquid crystal layer through the voltage.

Abstract: In order to reduce the sizes of a tunable optical filter and an external-resonator-type tunable semiconductor laser device, the filter includes: a silicon substrate; a glass substrate which is disposed opposed to the face of the silicon substrate and is equipped with a transparent electrode layer provided over the face thereof disposed to the substrate; an optical diffracting-and-reflecting layer disposed over the face of the silicon substrate; and a liquid crystal layer disposed between the optical diffracting-and-reflecting layer and the transparent electrode layer; and the filter is characterized in that in the filter where the refractive index of the liquid crystal layer is controlled by the voltage applied between the silicon substrate and the transparent electrode layer, a silicon-substrate-side electrode terminal for applying the voltage thereto is provided on the backside of the silicon substrate, this filter being assembled in the external-resonator-type tunable semiconductor laser device.

Abstract: A method for manufacturing a GRIN lens includes the steps of forming a wet gel provided with a concentration distribution having a different concentration of a refractive index distribution imparting metal that differs in concentration in a radial direction, drying the wet gel to form a dry gel having a bulk specific gravity ? (g/cm3), sintering the dry gel to form a GRIN lens base material and stretching the GRIN lens base material while heating. The method is characterized in that, in the step of sintering the dry gel, partial pressures of oxygen during sintering at 800° C. or higher are 10?1 Pa or lower and also the relation between a rate of temperature increase ? (° C./hr) and a bulk density ? of the dry gel during sintering at 1,000 to 1,150° C. is defined by ??105*EXP (?12?). As a result of this, the GRIN lens, which has a large numerical aperture and a small diameter, can stably and easily be manufactured.

Abstract: A fiber optic collimator system, a fiber optic collimator array, and a fiber optic collimator array system, which can reduce difficulty in an alignment process, minimize a coupling loss, and prevent the optical characteristics from deteriorating. An optical fiber is fused to one end of a GRIN lens made of quartz glass containing one or more selected from Sb2O3, Ta2O5, TiO2 and ZrO2 as a refractive index regulating substance, to form an optical fiber with a GRIN lens. Since an adhesive is not used, the core alignment of the GRIN lens and the optical fiber can be facilitated by a self alignment effect without deteriorating the optical characteristics. Moreover, the coupling loss is remarkably reduced by appropriately setting a refractive index distribution constant g of the GRIN lens.

Abstract: An optical fiber coupling part capable of reducing coupling loss while maintaining a large operating distance, and having a good module assembling property. AT least one GRIN lens having numerical aperture NA that is larger than numerical aperture NAs of a light-emitting source (such as a semiconductor laser) is fusion-spliced with one end of the optical fiber. All lights emitted from the light-emitting source can enter the GRIN lens, and the loss of the light can thereby be reduced. In addition, a second GRIN lens having numerical aperture NA2 is fusion-spliced with one end of the optical fiber having numerical aperture NAf, and further a first GRIN lens having numerical aperture NA1, which is larger than numerical aperture NA2, is fusion-spliced with the other end of the second GRIN lens. Thereby, the light emitted from the light-emitting source can efficiently enter the optical fiber, and loss of the light can thereby be reduced. In this case, the formula expressed by NAf?NA2<NAs?NA1 is desirable.

Abstract: It is intended to provide a method of designing an antiallergic agent, a sleep controlling agent, an antiobestic and a remedy for brain injury acting via the inhibition of the biosynthesis of prostaglandin D2. Crystals of a complex of human-origin hematopoietic prostaglandin D synthase, glutathione and a substrate analog or an inhibitor, etc. are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.