Patents by Inventor Hiroyuki Hashizume
Hiroyuki Hashizume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150224099Abstract: The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.Type: ApplicationFiled: February 13, 2015Publication date: August 13, 2015Inventors: Makoto MATSUMOTO, Hiroyuki HASHIZUME, Tatsuo TOMISHIGE, Masanori KAWASAKI, Yoshihiko SHIMOKAWA
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Patent number: 9051333Abstract: The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl.Type: GrantFiled: April 13, 2012Date of Patent: June 9, 2015Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu Kawano, Yoshikazu Haraguchi, Hirofumi Sasaki, Yukitaka Uematsu, Hidetsugu Tsubouchi, Hiromi Yata, Hiroshi Shimizu, Kazuho Kohashi, Motohiro Itotani, Kuninori Tai, Isao Takemura, Mikayo Hayashi, Hiroyuki Hashizume, Miki Matsuba, Izuru Nakamura, Xiuhao Chen, Makoto Matsumoto
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Patent number: 8987304Abstract: The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.Type: GrantFiled: October 4, 2006Date of Patent: March 24, 2015Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Masanori Kawasaki, Yoshihiko Shimokawa
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Publication number: 20140031342Abstract: The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl.Type: ApplicationFiled: April 13, 2012Publication date: January 30, 2014Applicant: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikazu Kawano, Yoshikazu Haraguchi, Hirofumi Sasaki, Yukitaka Uematsu, Hidetsugu Tsubouchi, Hiromi Yata, Hiroshi Shimizu, Kazuho Kohashi, Motohiro Itotani, Kuninori Tai, Isao Takemura, Mikayo Hayashi, Hiroyuki Hashizume, Miki Matsuba, Izuru Nakamura, Xiuhao Chen, Makoto Matsumoto
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Patent number: 8163753Abstract: The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and β(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.Type: GrantFiled: October 29, 2004Date of Patent: April 24, 2012Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Hidetsugu Tsubouchi, Hirofumi Sasaki, Motohiro Itotani, Yoshikazu Haraguchi, Shin Miyamura, Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Masanori Kawasaki, Kinue Ohguro, Takumi Sumida, Takeshi Hasegawa, Kazuho Tanaka, Isao Takemura
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Publication number: 20090275528Abstract: The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.Type: ApplicationFiled: October 4, 2006Publication date: November 5, 2009Inventors: Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Masanori Kawasaki, Yoshihiko Shimokawa
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Publication number: 20080119478Abstract: The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and β(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.Type: ApplicationFiled: October 29, 2004Publication date: May 22, 2008Inventors: Hidetsugu Tsubouchi, Hirofumi Sasaki, Motohiro Itotani, Yoshikazu Haraguchi, Shin Miyamura, Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Masanori Kawasaki, Kinue Ohguro, Takumi Sumida, Takeshi Hasegawa, Kazuho Tanaka, Isao Takemura
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Patent number: 7262212Abstract: The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group βOR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and β(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.Type: GrantFiled: October 10, 2003Date of Patent: August 28, 2007Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Hidetsugu Tsubouchi, Hirofumi Sasaki, Hideaki Kuroda, Motohiro Itotani, Takeshi Hasegawa, Yoshikazu Haraguchi, Takeshi Kuroda, Takayuki Matsuzaki, Kuninori Tai, Makoto Komatsu, Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Yuji Seike, Masanori Kawasaki, Takumi Sumida, Shin Miyamura
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Patent number: 5999495Abstract: A timepiece movement comprises a first luminous element for emitting light, a second luminous element for emitting light, and a light-receiving element for receiving the light emitted by the first and second luminous elements. A second wheel has an aperture through which light from the first luminous element may pass and a reflecting portion. A first transmitting wheel transmits a rotational drive to the second wheel as a function of second time and has an aperture through which light from the first luminous element may pass and which is positioned to become aligned with the aperture of the second wheel. A rotational minute wheel has apertures disposed at equal angular intervals and through which light from the second luminous element may pass. A rotational hour wheel has apertures through which light from the second luminous element may pass.Type: GrantFiled: November 5, 1997Date of Patent: December 7, 1999Assignee: Seiko Clock Inc.Inventors: Hiroyuki Hashizume, Koji Baba
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Patent number: 5930205Abstract: A timepiece movement comprises a light-emitting device for emitting light and a light-receiving device for receiving the light emitted from the light-emitting device. An hour wheel has a plurality of apertures through which light from the light-emitting device may pass. A minute wheel has an aperture through which light from the light-emitting device may pass, the aperture being positioned to become aligned with respective ones of the apertures of the hour wheel during rotation of the minute and hour wheels. Minute and hour wheel gear trains respectively rotate the minute wheel and the hour wheel as a function of minute and hour time.Type: GrantFiled: October 20, 1997Date of Patent: July 27, 1999Assignee: Seiko Clock Inc.Inventors: Koji Baba, Hiroyuki Hashizume
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Patent number: 5566140Abstract: A clock movement includes a circuit board, first and second motors, a minute wheel connected to the first motor by a first gear train and an hour wheel connected to the second motor by a second gear train. The first and second gear trains preferably extend in a first direction, and the first and second motors are respectively disposed on opposite sides of the first and second gear trains and extend in a second direction transverse to the first direction. A first detection device detects when the minute hand is in a predetermined reference position and a second detection device detects when the hour wheel is in a predetermined reference position. The first detection device includes a minute detection sensor mounted on the circuit board and having a first light-emitting device and a first light-receiving device. The second detection device includes an hour detection sensor mounted on the circuit board and having a second light-emitting device and a second light-receiving device.Type: GrantFiled: September 12, 1995Date of Patent: October 15, 1996Assignee: Seiko Clock Inc.Inventors: Shigeru Kohata, Hiroyuki Hashizume
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Patent number: 4492545Abstract: In a cam ring of a vane pump having a contoured bore whole wall is constantly and slidingly engaged by the radially outermost ends of vanes during rotation of a rotor, a radially inner part of the cam ring including the wall of the contoured bore is formed of sintered alloy while a radially outer part surrounding the inner part is formed of a material which prevents working fluid from oozing out therethrough. The outer part comprises a moulding of plastics, a die casting or a piece blanked from a steel sheet.Type: GrantFiled: April 1, 1982Date of Patent: January 8, 1985Assignee: Kayaba Kogyo Kabushiki KaishaInventors: Norihiro Mochizuki, Hiroyuki Hashizume
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Patent number: 4047846Abstract: The present invention discloses a power-steering pump which may reduce in a very stable manner the flow rate of the hydraulic liquid under pressure to be delivered to a power steering system with increase of the rotational speed of an engine beyond an idling speed and which may easily change the above rate reduction or attenuation characteristic depending upon the types of the automotive vehicles and power steering systems thereof. A flow-control valve which is disposed in parallel with the axis of a pump mechanism is provided with a variable-area orifice which determines the flow rate attenuation characteristic and which is defined by an orifice groove cut through a flange of a partition wall member and an enlarged-diameter portion at the free end of a control rod extended through the partition wall member from the front end of a control spool of the flow-control valve.Type: GrantFiled: May 18, 1976Date of Patent: September 13, 1977Assignee: KayabakogyokabushikikaishaInventors: Seiji Komamura, Hiroyuki Hashizume