Patents by Inventor Hiroyuki Kagechika
Hiroyuki Kagechika has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230150952Abstract: Providing a RyR2 activity inhibitor having an excellent RyR2 activity inhibitory effect.Type: ApplicationFiled: February 10, 2021Publication date: May 18, 2023Applicant: JUNTENDO EDUCATIONAL FOUNDATIONInventors: Nagomi Kurebayashi KUNIHIRO, Takashi MURAYAMA, Hiroyuki KAGECHIKA, Shuichi MORI, Mari YUASA, Hiroto IINUMA
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Patent number: 10653672Abstract: The invention provides a novel myogenesis promotor, a novel muscle atrophy inhibitor, a novel composition or a novel TAZ activator. The myogenesis promotor, the muscle atrophy inhibitor, the composition and the TAZ activator include a composition represented by the following Formula (I) as an active ingredient. In Formula (I), R1 represents a hydrogen atom or an alkyl group; R2 represents an aryl group, a heterocyclic group, an alkyl group or the like; R3 represents —NR5R6 or —N?C—R7; each of R5 and R6 independently represents a hydrogen atom, an alkyl group or the like; R7 represents —NR10R11, an aryl group or a heterocyclic group; R8 represents a hydrogen atom, an alkyl group or the like; R9 represents a hydrogen atom, an alkyl group or the like; each of R10 and R11 independently represents a hydrogen atom, an alkyl group or the like; R4 represents a cyano group or —C(?O)R12; and R12 represents an aryl group, a heterocyclic group, an alkyl group or the like.Type: GrantFiled: February 6, 2015Date of Patent: May 19, 2020Assignee: National University Corporation Tokyo Medical and Dental UniversityInventors: Yutaka Hata, Hiroyuki Kagechika, Kentaro Nakagawa, Shigeru Ito
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Patent number: 10266482Abstract: [Problem] To provide a method for inducing a long-term memory in a subject in need thereof. [Solution to problem] A method for inducing a long-term memory, comprising a step of administering a compound represented by Formula I below, a pharmaceutically acceptable salt thereof or a solvate thereof to the subject.Type: GrantFiled: May 12, 2017Date of Patent: April 23, 2019Assignees: National University Corporation Tokyo Medical and Dental University, Sophia School CorporationInventors: Atsuhiko Hattori, Yukihisa Matsumoto, Hiroyuki Kagechika, Hiroyuki Masuno, Atsuhiko Chiba, Hikaru Iwashita, Yusuke Maruyama
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Publication number: 20180327348Abstract: [Problem] To provide a method for inducing a long-term memory in a subject need thereof. [Solution to problem] A method for inducing a long-term memory, comprising a step of administering a compound represented by Formula I below, a pharmaceutically acceptable salt thereof or a solvate thereof to the subject.Type: ApplicationFiled: May 12, 2017Publication date: November 15, 2018Inventors: Atsuhiko HATTORI, Yukihisa MATSUMOTO, Hiroyuki KAGECHIKA, Hiroyuki MASUNO, Atsuhiko CHIBA, Hikaru IWASHITA, Yusuke MARUYAMA
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Publication number: 20160346251Abstract: The invention provides a novel myogenesis promotor, a novel muscle atrophy inhibitor, a novel composition or a novel TAZ activator. The myogenesis promotor, the muscle atrophy inhibitor, the composition and the TAZ activator include a composition represented by the following Formula (I) as an active ingredient. In Formula (I), R1 represents a hydrogen atom or an alkyl group; R2 represents an aryl group, a heterocyclic group, an alkyl group or the like; R3 represents —NR5R6 or —N?C—R7; each of R5 and R6 independently represents a hydrogen atom, an alkyl group or the like; R7 represents —NR10R11, an aryl group or a heterocyclic group; R8 represents a hydrogen atom, an alkyl group or the like; R9 represents a hydrogen atom, an alkyl group or the like; each of R10 and R11 independently represents a hydrogen atom, an alkyl group or the like; R4 represents a cyano group or —C(?O)R12; and R12 represents an aryl group, a heterocyclic group, an alkyl group or the like.Type: ApplicationFiled: February 6, 2015Publication date: December 1, 2016Inventors: Yutaka Hata, Hiroyuki Kagechika, Kentaro Nakagawa, Shigeru Ito
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Patent number: 8431613Abstract: A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.Type: GrantFiled: April 30, 2012Date of Patent: April 30, 2013Assignees: Research Foundation ITSUU Laboratory, Kemphys Inc.Inventors: Koichi Shudo, Hiroyuki Kagechika
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Publication number: 20120214763Abstract: A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.Type: ApplicationFiled: April 30, 2012Publication date: August 23, 2012Applicants: KEMPHYS LTD., RESEARCH FOUNDATION ITSUU LABORATORYInventors: Koichi SHUDO, Hiroyuki KAGECHIKA
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Patent number: 8198329Abstract: A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.Type: GrantFiled: March 9, 2005Date of Patent: June 12, 2012Assignees: Research Foundation Itsuu Laboratory, Kemphys Ltd.Inventors: Koichi Shudo, Hiroyuki Kagechika
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Patent number: 8168677Abstract: Method for therapeutic treatment of inflammatory bowel disease, including Crohn's disease, comprising administering to a patient in need thereof a therapeutically effective amount of a composition comprising a retinoid as an active ingredient to treat the inflammatory bowel disease, the retinoid being selected from the group consisting of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid, 4-[(3,5-bis-trimethylsilylphenyl)carboxamido]benzoic acid, 4-[2,3-(2,5-dimethyl-2,5-hexano)dibenzo[b,f][1,4]thiazepin-11-yl]benzoic acid, and 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid.Type: GrantFiled: September 14, 2009Date of Patent: May 1, 2012Assignee: Kemphys Ltd.Inventors: Koichi Shudo, Hiroyuki Kagechika, Hiroshi Fukasawa, Tetsuro Matsuishi, Naoko Katsumura, Miwako Ishido
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Patent number: 8105833Abstract: A method for forming an organ and/or tissue from undifferentiated cells derived from a vertebrate animal in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid X receptor ligand (e.g., a retinoic acid X receptor agonist or antagonist), and a method for forming a pancreas from undifferentiated cells derived from a vertebrate animal in vitro or a method for forming a tissue having morphology and function of a pancreas from undifferentiated cells derived from a vertebrate in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid receptor ligand, together with activin, that does not substantially bind to the retinoic acid receptor subtype ?.Type: GrantFiled: August 4, 2009Date of Patent: January 31, 2012Assignee: Research Foundation Itsuu LaboratoryInventors: Makoto Asashima, Tatsuo Hamazaki, Hiroyuki Kagechika, Koichi Shudo
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Patent number: 8071647Abstract: Method for suppressing adhesion of the intestines or therapeutic treatment of adhesion of the intestines comprising administering to a patient in need thereof a therapeutically effective amount of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid. There is also provided a medicament for suppressing adhesion of the intestines and/or therapeutic treatment of bowel diseases such as inflammatory bowel diseases, including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.Type: GrantFiled: August 31, 2010Date of Patent: December 6, 2011Inventors: Koichi Shudo, Hiroyuki Kagechika, Hiroshi Fukasawa, Tetsuro Matsuishi, Naoko Katsumura, Miwako Ishido
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Publication number: 20100324134Abstract: A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.Type: ApplicationFiled: August 31, 2010Publication date: December 23, 2010Applicant: KEMPHYS LTD.Inventors: Koichi SHUDO, Hiroyuki KAGECHIKA, Hiroshi FUKASAWA, Tetsuro MATSUISHI, Naoko KATSUMURA, Miwako ISHIDO
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Publication number: 20100004203Abstract: A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.Type: ApplicationFiled: September 14, 2009Publication date: January 7, 2010Applicant: KEMPHYS LTD.Inventors: Koichi SHUDO, Hiroyuki KAGECHIKA, Hiroshi FUKASAWA, Tetsuro MATSUISHI, Naoko KATSUMURA, Miwako ISHIDO
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Publication number: 20090291492Abstract: A method for forming an organ and/or tissue from undifferentiated cells derived from a vertebrate animal in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid X receptor ligand (e.g., a retinoic acid X receptor agonist or antagonist), and a method for forming a pancreas from undifferentiated cells derived from a vertebrate animal in vitro or a method for forming a tissue having morphology and function of a pancreas from undifferentiated cells derived from a vertebrate in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid receptor ligand, together with activin, that does not substantially bind to the retinoic acid receptor subtype ?.Type: ApplicationFiled: August 4, 2009Publication date: November 26, 2009Applicant: Research Foundation Itsuu LaboratoryInventors: Makoto ASASHIMA, Tatsuo HAMAZAKI, Hiroyuki KAGECHIKA, Koichi SHUDO
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Publication number: 20090270612Abstract: It is an object of the present invention to provide a novel therapeutic agent for osteoporosis. HX531 is utilized, which is synthesized as a retinoid X receptor antagonist and has an activity in inhibiting a differentiation into adipocytes. Furthermore, any dosage form containing HX531 as an effective component can be used.Type: ApplicationFiled: September 4, 2006Publication date: October 29, 2009Inventors: Nobuyuki Udagawa, Midori Nakamura, Hiroyuki Kagechika
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Publication number: 20090253796Abstract: A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an intravascular stent, which comprises as an active ingredient a substance selected from the group consisting of retinoids and agents for controlling actions of retinoids such as 4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or a salt thereof, or 4-[[[3,5-bis-(trimethylsilyl)phenyl]carbonyl]amino]benzoic acid or a salt thereof, wherein said substance has substantially no antiproliferative action on vascular endothelial cells, but substantially has antiproliferative action on vascular smooth muscle cells.Type: ApplicationFiled: March 27, 2009Publication date: October 8, 2009Applicant: Research Foundation Itsuu LaboratoryInventors: Ryozo NAGAI, Takayuki Shindo, Ichiro Manabe, Koichi Shudo, Hiroyuki Kagechika
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Publication number: 20090118264Abstract: Methods of use of medicaments having neovascularization promoting action, which medicaments comprise a retinoid antagonist such as 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1-,4]diazepin-13-yl)benzoic acid as an active ingredient.Type: ApplicationFiled: December 23, 2008Publication date: May 7, 2009Applicants: Research Foundation Itsuu Laboratory, Ryozo NAGAI, Ichiro MANABE, Takayuki SHINDO, Hiroshi IWATAInventors: Ryozo Nagai, Ichiro Manabe, Takayuki Shindo, Hiroshi Iwata, Koichi Shudo, Hiroyuki Kagechika
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Publication number: 20080255069Abstract: A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.Type: ApplicationFiled: September 7, 2006Publication date: October 16, 2008Applicant: R & R INC.Inventors: Koichi Shudo, Hiroyuki Kagechika, Hiroshi Fukasawa, Tetsuro Matsuishi, Naoko Katsumura, Miwako Ishido
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Publication number: 20080021108Abstract: A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthaleny)carbamoyl]benzoic acid or 4- [(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.Type: ApplicationFiled: March 9, 2005Publication date: January 24, 2008Applicants: RESEARCH FOUNDATION ITSUU LABORATORY, R&R INC.Inventors: Koichi Shudo, Hiroyuki Kagechika
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Patent number: 7314639Abstract: A method for preparing a crystal of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid having a single endothermic peak approximately at 233° C. in differential scanning calorimetry, which comprises the step of recrystallizing a crystal of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid from a mixture of water and ethanol. The method enables selective preparation of type-II crystals which are stable against physical impact. The resulting crystals are free from highly toxic hexane as a residual solvent, and preferably used as an active ingredient of pharmaceuticals.Type: GrantFiled: August 31, 2001Date of Patent: January 1, 2008Assignees: Toko Pharmaceutical Ind. Co., Ltd., Research Foundation Itsuu LaboratoryInventors: Hiroyuki Kagechika, Hiroo Nagano