Abstract: A centrifugal compressor, the capacity of which can be increased with keeping the diameter of the impeller at minimum, is provided. The centrifugal compressor includes: a drive gear (11); a drive shaft (3) protruding from one side of the drive gear (11) in a central axis direction of the drive gear (11); a no. 1 driven pinion gear (12) configured for rotation of the drive gear (11) to be transmitted thereto; a no. 1 driven pinion shaft (5) protruding from both sides of the no. 1 driven pinion gear (12) in a central axis direction of the no. 1 driven pinion gear (12); and a couple of first stage compressor sections (7a, 7b), each of which is provided in each end of the no. 1 driven pinion shaft (5) and is configured to compress fluid by rotation of the no. 1 driven pinion shaft (5).

Abstract: A compressing system includes a compression section that compresses a target gas to an intermediate pressure, which is equal to or higher than a critical pressure and lower than a target pressure to generate an intermediate supercritical fluid, a cooling section that cools the intermediate supercritical fluid generated in the compression section to near a critical temperature to generate an intermediate supercritical pressure liquid, and a pumping section that compresses the intermediate supercritical pressure liquid generated in the cooling section to a pressure that is equal to or higher than the target pressure. At least one of the intermediate supercritical pressure liquid compressed in the pumping section, a low-temperature liquid generated by extracting the intermediate supercritical pressure liquid on the upstream side of the pumping section to reduce pressure to near the critical pressure, and an external cooling medium is used as a cooling medium in the cooling section.

Abstract: A seat damper attached between a vehicle body and a seat in a seat suspension structure. The seat damper capable of allowing misalignment of mounting positions of mounting parts between the vehicle body side and the seat side, and being configured with reduced rigidity. The seat damper includes: a resilient member interposed between a vehicle body and a seat, supporting a load applied thereto; a seat-side bearing plate and a vehicle body-side bearing plate sandwiching the resilient member; a rod including a joint for pivotably coupling the rod to the seat-side bearing plate and a locking portion at the other end locking the rod to a lower face of the vehicle body-side bearing plate, with this joint being received in and locked to the seat-side bearing plate; and a ring-like rod guide provided to the vehicle body-side bearing plate for the rod to pass through.

Abstract: A method for producing prasugrel hydrochloride with a reduced content of 2-acetoxy-5-[5-chloro-1-(2-fluorophenyl)-2-oxopentyl]-4,5,6,7-tetrahydrothieno[3,2-6]pyridine by carrying out the following steps: wherein R represents a protecting group for a hydroxyl group.

Abstract: The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.

Abstract: A method of evaluating astigmatism of an irradiation system irradiating an electron beam is disclosed. In this method, a figure pattern consisting of plural (for example, four) concentric circles is formed on a reference sample “WP” and an image (scanned image) is formed based on an electron signal obtained by scanning the electron beam onto the reference sample “WP”. In the scanned image, the image has a blur in a region with its longitudinal direction parallel to the generating direction of the astigmatism and the size of the blur depends on magnitude of the astigmatism. Therefore, the direction and the magnitude of the astigmatism of the irradiation system of an irradiation apparatus can be detected based on the obtained scanned image.

Abstract: Provided is a machine unit layout system that simplifies the layout of a compressor unit and an expander unit and is extremely effective in terms of not only the reliability of the entire machine but also maintainability. Two separate compressors, a low-pressure-side compressor and a high-pressure-side compressor (11A, 11b), are disposed on either side of a steam turbine (10). Two separate expanders, a low-pressure-side expander and a high-pressure-side expander (12A, 12B), are disposed outside the low-pressure-side and high-pressure-side compressors (11A, 11b). The steam turbine (10), the low-pressure-side and high-pressure-side compressors (11A, 11b), and the low-pressure-side and high-pressure-side expanders (12A, 12B) are coupled by rotor shafts comprising a single shaft. The torque distribution between rotator shafts is optimized.

Abstract: The present invention discloses a process for preparing an optically active (S or R)-?-amino acid represented by the formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, heteroarylalkyl group, aryl group or heteroaryl group, each of which may have a substituent(s), and * represents an asymmetric carbon atom, and an optically active (R or S)-?-amino acid ester represented by the formula (III): wherein R1 represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has an opposite absolute configuration to that of the compound of the formula (II), which comprises selectively reacting water with one of enantiomers of an ?-amino acid ester which is a racemic mixture and represented by the formula (I): wherein R and R1 have the same meanings as defined above, in the presence of a lipase or a protease in an organic solvent.

Abstract: The present inventions are directed to novel crystal forms of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,4,5,6-tetrahydro-6-oxopyridazin-3-yl)-1H-pyrazole methanesulfonate, which is useful as a pharmaceutical product, and methods for their preparation. The present inventions provide two stable crystalline polymorphs called A-form crystal and B-form crystal as well as methods for their preparation, by which each crystalline polymorph can be individually obtained as a single crystal form.

Abstract: A process for preparing an optically active (S or R)-?-amino acid represented by formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, aryl group or heteroaryl group each of which may have a substituent(s), and * represents an asymmetric carbon atom, and an optically active (R or S)-?-amino acid ester represented by formula (III): wherein R has the same meaning as defined above, R1 represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has a reverse absolute configuration to that of the compound of the formula (II), which comprises selectively hydrolyzing water and one of enantiomers of a ?-amino acid ester represented by formula (I): wherein R and R1 have the same meanings as defined above, which is a racemic mixture, in the presence of a hydrolase in an organic solvent.

Abstract: A combined power generation unit includes a gasification unit with a gasification furnace that is used to produce fuel gas, and a gas turbine that uses the fuel gas to generate power. To produce the fuel gas required in the combined power generation unit according to a required power load, a feed-forward control of the gasification unit is performed. Also, a dead time compensator compensates for a lag and a dead time occurring while the fuel gas is fed from the gasification unit to the combined power generation unit. The gasification unit is operated using a zero flare process. The dead time compensator delays the power load required in the combined power generation unit on the basis of the lag and the dead time of the gasification unit so that the combined power generation unit is operated while a follow-up is performed with a predetermined delay.

Abstract: A gasification unit provided with a gasification furnace 23 to produce fuel gas production is provided. A combined power generation unit 25 which generates power by rotating a gas turbine and a steam turbine using fuel gas produced in the gasification unit is provided. The combined power generation unit 25 is made operable while fuel change over between fuel gas and an auxiliary fuel as the fuel. A control system is provided in which the degree of opening of a control valve 37 for a flare stack 28 provided in a fuel gas feed line is controlled depending upon the pressure of the fuel gas from the gasification unit when fuel change over from the fuel gas to the auxiliary fuel so as to allow the fuel gas supplied to the combined power generation unit 25 to gradually flare from a flare stack 28 until a flared status that total amount of the fuel gas is reached.

Abstract: A method of evaluating astigmatism of an irradiation system irradiating an electron beam is disclosed. In this method, a figure pattern consisting of plural (for example, four) concentric circles is formed on a reference sample “WP” and an image (scanned image) is formed based on an electron signal obtained by scanning the electron beam onto the reference sample “WP”. In the scanned image, the image has a blur in a region with its longitudinal direction parallel to the generating direction of the astigmatism and the size of the blur depends on magnitude of the astigmatism. Therefore, the direction and the magnitude of the astigmatism of the irradiation system of an irradiation apparatus can be detected based on the obtained scanned image.

Abstract: An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. In the formulae, R represents a protecting group for a hydroxyl group. A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.

Abstract: The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.

Abstract: The present invention relates to a process for preparing a carboxylic acid using a surfactant-modified enzyme which comprises selectively reacting water and a carboxylic acid ester, provided that triglyceride is excluded, in an organic solvent in the presence of a surfactant-modified enzyme.

Abstract: A gasification unit provided with a gasification furnace 23 to produce fuel gas production is provided. A combined power generation unit 25 which generates power by rotating a gas turbine and a steam turbine using fuel gas produced in the gasification unit is provided. The combined power generation unit 25 is made operable while fuel change over between fuel gas and an auxiliary fuel as the fuel. A control system is provided in which the degree of opening of a control valve 37 for a flare stack 28 provided in a fuel gas feed line is controlled depending upon the pressure of the fuel gas from the gasification unit when fuel change over from the fuel gas to the auxiliary fuel so as to allow the fuel gas supplied to the combined power generation unit 25 to gradually flare from a flare stack 28 until a flared status that total amount of the fuel gas is reached.

Abstract: The present invention discloses a process for preparing an optically active (S or R)-?-amino acid represented by the formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, heteroarylalkyl group, aryl group or heteroaryl group, each of which may have a substituent(s), and * represents an asymmetric carbon atom, and an optically active (R or S)-?-amino acid ester represented by the formula (III): wherein R1 represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has an opposite absolute configuration to that of the compound of the formula (II), which comprises selectively reacting water with one of enantiomers of an ?-amino acid ester which is a racemic mixture and represented by the formula (I): wherein R and R1 have the same meanings as defined above, in the presence of a lipase or a protease in an organic solvent.

Abstract: The present invention discloses a process which comprises selectively hydrolyzing one enantiomer of racemic mixtures of an N-substituted ?-amino acid alkyl ester or N-substituted 2-homopipecolic acid ester represented by the formula (I): wherein Ar, R1, R2, R3, R4 and R5 are the same as defined in the specification, in the presence of a hydrolase to form an optically active ((R) or (S))—N-substituted ?-amino acid or optically active ((R) or (S))—N-substituted 2-homopipecolic acid represented by the formula (II): and simultaneously to obtain an unreacted optically active ((S) or (R))—N-substituted ?-amino acid alkyl ester or unreacted optically active ((S) or (R))—N-substituted 2-homopipecolic acid ester represented by the formula (III): which has a reverse steric absolute configuration to that of the compound represented by the formula (II).