Abstract: A culture bag includes a culture portion which has a culture space configured to contain and culture a culture fluid. The culture space is an endless circumferential circulation space in which the culture fluid can circumferentially circulate. The culture fluid can continue to circumferentially circulate in one direction in the endless culture space. This suppresses complexification of flow of the culture fluid. As a result, bubbles can be suppressed from generating without decreasing culture efficiency.

Abstract: A method of manufacturing a solid freeform fabrication includes forming a liquid film constituting a model part and a detail part with a model part forming material and a detail part forming material, respectively, curing the liquid film, repeating the forming and the curing, wherein the model part includes one or more surfaces without a support and the detail part is disposed adjacent to at least one of the one or more surfaces.

Abstract: A method of fabricating a solid freeform fabrication object, includes discharging multiple liquid droplets of modeling material and multiple liquid droplets of supporting material to a stage by a discharging device, merging the multiple liquid droplets of the modeling material into a liquid droplet of the modeling material in the air and the multiple liquid droplets of the supporting material into a liquid droplet of the supporting material in the air, curing the liquid droplet of the modeling material and the liquid droplet of the supporting material on the stage to form a layered fabrication object, and repeating the discharging and the curing to laminate the layered fabrication object to manufacture the solid freeform fabrication object, wherein the discharging device stands still during at least the discharging to a boundary area of the modeling material and the supporting material on the stage.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- or -L1-L2-LP- wherein the antibody is connected to the terminal of L1, the antitumor compound is connected to the terminal of Lc or LP, and any one or two or more of linkers of L1, L2, and LP has a hydrophilic structure.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- or -L1-L2-LP- wherein the antibody is connected to the terminal of L1, the antitumor compound is connected to the terminal of Lc or LP, and any one or two or more of linkers of L1, L2, and LP has a hydrophilic structure.

Abstract: An active energy ray liquid composition is provided. A cured product of the active energy ray curable liquid composition is a solid at 25° C. and a liquid at 60° C., and the solid exhibits a compression stress of 2.0 kPa or more when compressed 1%.

Abstract: A method of manufacturing a solid freeform fabrication object includes forming a layer by solidifying a curable liquid composition by a solidifying device to form a solidified layer, repeating the forming to laminate the solidified layer to form a model portion and a support to support the model portion, and removing the support, wherein the support includes a water decaying area and the area other than the water decaying area, the water decaying area forming a continuous area including the surface of the support in contact with the model portion and at least a part of the surface of the support not in contact with the model portion.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A solid freeform fabrication object includes a hydrogel including a polymer, water, and a coloring material inclusion substance.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the formula: L1-L2-LP-NH—(CH2)n1-La-Lb-Lc or -L1-L2-LP- wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the terminal Lc or LP with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: A method of manufacturing a three-dimensional object includes imparting a first liquid having a first composition including a solvent and a curable material and a second liquid having a second composition to form a liquid film, curing the liquid film, and repeating the imparting and the curing to obtain the three-dimensional object, wherein the imparting position and the imparting amount of each of the first liquid and the second liquid are controlled in such a manner that the liquid film includes multiple areas where at least one of post-curing compression stress and post-curing modulus of elasticity is different.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2—C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2—C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: A colored composition includes: an azomethine pigment represented by the following Formula (1) and having a solubility in n-hexane of 1% by mass or more at 25° C. and 0.1 MPa; and a non-polar solvent: wherein, in Formula (1), Het1 represents a ring having no dissociable group and Ar represents an aromatic ring having no dissociable group or a saturated heterocycle having no dissociable group.

Abstract: Provided are a method for manufacturing 3,4,5-tricaffeoylquinic acid, which can produce 3,4,5-tricaffeoylquinic acid with high efficiency by a simple operation in a short process using inexpensive raw materials, and intermediate compounds.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An electrowetting display device that includes a display member having: a first substrate in which at least one surface has conductivity, a second substrate which is disposed to face the conductive surface of the first substrate, a hydrophobic insulating film which is provided on the conductive surface of the first substrate, an oil, which is non-conductive, provided between the hydrophobic insulating film and the second substrate so as to be movable on the hydrophobic insulating film, and containing a nonpolar solvent and a methine dye including two dye mother nuclei that are linked through a linking group having a methine unsaturated chain, and a hydrophilic liquid which is conductive, provided between the hydrophobic insulating film and the second substrate so as to be in contact with the oil.

Abstract: The electrowetting display apparatus includes a display unit including: a first substrate at least one surface of which is electroconductive; a second substrate disposed to face the electroconductive surface of the first substrate; a hydrophobic insulation film disposed on the electroconductive surface side of the first substrate; a non-electroconductive oil which is provided between the hydrophobic insulation film and second substrate movably on the hydrophobic insulation film and includes a non-polar solvent and an azamethine-based colorant containing two colorant mother nuclei bonded via a linking group represented by ?N—; and an electroconductive hydrophilic liquid provided between the hydrophobic insulation film and second substrate to contact the oil; in which an image is displayed by applying a voltage between the hydrophilic liquid and the electroconductive surface of first substrate and changing the shape of interface between the oil and hydrophilic liquid.

Abstract: Provided are a method for manufacturing 3,4,5-tricaffeoylquinic acid, which can produce 3,4,5-tricaffeoylquinic acid with high efficiency by a simple operation in a short process using inexpensive raw materials, and intermediate compounds.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- or -L1-L2-LP- wherein the antibody is connected to the terminal of L1, the antitumor compound is connected to the terminal of Lc or LP, and any one or two or more of linkers of L1, L2, and LP has a hydrophilic structure.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.