Abstract: An image forming apparatus includes a first unit including an image bearing member and a second unit. The second unit includes a developing roller to supply the toner to the image bearing member, a mounting portion in which the replenishing container is dismountably mounted and an accommodating portion to accommodate the toner replenished from the replenishing container. The second unit is movable between a first position where the developing roller contacts the image bearing member and a second position where the developing roller separates from the image bearing member. When a moving direction in which the second unit moves from the first position toward the second position is defined as a separating direction, the second unit is urged in the separating direction by a force which the mounting portion receives from the replenishing container when the replenishing container is mounted to the mounting portion.

Abstract: A material comprising: a support 10; and a brush layer 20 containing a brush-like polymer chain assemblage 21 formed of a plurality of polymer chains and a swelling liquid 22, in which a brush layer 20 is swollen with the swelling liquid 22, the brush layer 20 retaining on the surface a lubricating liquid 30, and the swelling liquid 22 contained in the brush layer 20 and the lubricating liquid 30 being phase-separated to form a liquid-liquid phase separation interface 40 in between and a sliding system using the material.

Abstract: A fixing device includes a belt having a tubular shape and extending in a longitudinal direction, and having a longitudinal end, a drive roller to rotate the belt to convey a print medium between the drive roller and the belt, a bushing located at the longitudinal end of the belt, and a guide wall adjacent to the bushing. The belt is displaceable in the longitudinal direction relative to the bushing. The bushing includes a shoulder adjacent to the longitudinal end of the belt and a stem extending from the shoulder to an inside of the belt to support the belt. The guide guides the bushing to move in a direction opposite to a conveyance direction of the print medium when the belt moves toward the bushing. The stem of the bushing includes a convex portion that is in contact with an inner surface of the belt when the belt is displaced in the longitudinal direction.

Abstract: Disclosed is a method for treating osteoarthritis comprising a step of administering a patch to a patient. The patch comprises a backing layer and an adhesive layer laminated on the backing layer, the adhesive layer comprises an adhesive base, diclofenac sodium, dimethyl sulfoxide, and an organic acid, and a content of the organic acid is 6 mass % to 8 mass % with respect to a total mass of the adhesive layer. The patch is applied to an affected part once a day, and a dose of diclofenac sodium per administration is 70 mg to 150 mg.

Abstract: A fuel cell system includes a fuel cell that generates power using a fuel gas and an oxygen-containing gas, a reformer including a vaporizing section and a reforming section, a raw fuel supply that supplies raw fuel, a reformed water supply that supplies reformed water, and a controller. The controller has multiple calculation formulas for calculating an amount of reformed water to be used in the reforming section in response to a requested power level from an external unit, and selects, based on an increase or a decrease in a requested current level from the external unit, a formula from the multiple calculation formulas in response to the increase in the requested current level, and a formula different from the formula to be selected for the increase from the multiple calculation formulas in response to the decrease in the requested current level.

Abstract: The present disclosure provides a method for producing a fluororesin, which includes polymerizing a fluorine-containing monomer in the presence of a compound (1) having triple bond and a hydrophilic group and an aqueous medium to produce a fluororesin, a fluororesin comprising a unit based on a compound (1) having triple bond and a hydrophilic group, and a fluorine-containing monomer unit, and an aqueous dispersion comprising the fluororesin and an aqueous medium.

Abstract: It is an object of the present invention to provide polytetrafluoroethylene suitable for forming a porous polytetrafluoroethylene film using a high water-soluble surfactant with high volatility. Polytetrafluoroethylene has non-melt-secondary-processability, standard specific gravity of 2.160 or less, an average primary particle size of 150 nm or more, stress relaxation time of 500 seconds or more, and break strength of 29.7 N or more. The polytetrafluoroethylene is obtainable by emulsion polymerization of tetrafluoroethylene in the presence of a fluorinated surfactant with Log POW of 3.4 or less.

Abstract: A method for producing a fluoropolymer, which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a polymer (1), the polymer (1) including a polymerized unit derived from a monomer CX2?CY(—CZ2—O—Rf-A), wherein X is the same or different and is —H or —F; Y is —H, —F, an alkyl group, or a fluorine-containing alkyl group; Z is the same or different and is —H, —F, an alkyl group, or a fluoroalkyl group; Rf is a C1-C40 fluorine-containing alkylene group or a C-C100 fluorine-containing alkylene group and having an ether bond; and A is —COOM, —SO3M, or —OSO3M, wherein M is —H, a metal atom, —NR74, imidazolium optionally having a substituent, pyridinium optionally having a substituent, or phosphonium optionally having a substituent, wherein R7 is H or an organic group, providing that at least one of X, Y, and Z contains a fluorine atom.

Abstract: A non-transitory computer-readable recording medium storing a search program for causing a computer to execute processing including: obtaining a first cost value of a first potential that corresponds to interaction between coarse-grained particles, a second cost value of a second potential that corresponds to an angle and a dihedral angle between the particles, and a third cost value of a third potential that corresponds to repulsion and attraction between the particles; and instructing an Ising apparatus to search for a structure of a coarse-grained model with which a total sum of the first cost value, the second cost value, and the third cost value calculated for an entirety of the coarse-grained model that includes a plurality of particles satisfies a predetermined condition.

Abstract: A method for producing a fluoropolymer, which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a polymer (1), the polymer (1) including a polymerized unit derived from a monomer CX2?CY(—CZ2—O—Rf-A), wherein X is the same or different and is —H or —F; Y is —H, —F, an alkyl group, or a fluorine-containing alkyl group; Z is the same or different and is —H, —F, an alkyl group, or a fluoroalkyl group; Rf is a C1-C40 fluorine-containing alkylene group or a C—C100 fluorine-containing alkylene group and having an ether bond; and A is —COOM, —SO3M, or —OSO3M, wherein M is —H, a metal atom, —NR74, imidazolium optionally having a substituent, pyridinium optionally having a substituent, or phosphonium optionally having a substituent, wherein R7 is H or an organic group, providing that at least one of X, Y, and Z contains a fluorine atom.

Abstract: The present disclosure provides a technique for introducing an antigen receptor-encoding nucleic acid into a definite site in a nucleic acid that is contained in an immune cell of a target organism. In the technique according to the present disclosure, a vector, which contains an antigen receptor-encoding nucleic acid, and a nuclease are introduced into an immune cell. The nuclease cleaves the vector and the genome sequence of the immune cell. The vector can be configured so that, when cleaved with the nuclease, a sequence, which is an antigen receptor-encoding sequence and which is introduced by microhomology-mediated end-joining (MMEJ) at the nuclease cleavage site of the genome sequence of the immune cell, is formed.

Abstract: A method for producing a fluoropolymer which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a surfactant to provide a fluoropolymer, the surfactant being represented by the general formula (1): CR1R2R4—CR3R5—X-A, wherein R1 to R5 are each H or a monovalent substituent, with the proviso that at least one of R1 and R3 represents a group represented by the general formula: —Y—R6 and at least one of R2 and R3 represents a group represented by the general formula: —X-A or a group represented by the general formula: —Y—R6; and A is the same or different at each occurrence and is —COOM, —SO3M, or —OSO3M. Also disclosed is a surfactant for polymerization represented by the general formula (1), a method for producing a fluoropolymer using the surfactant, a composition including a fluoropolymer and the surfactant and a molded body including the composition.

Abstract: A fixing device includes a belt having a tubular shape and extending in a longitudinal direction, and having a longitudinal end, a drive roller to rotate the belt to convey a print medium between the drive roller and the belt, a bushing located at the longitudinal end of the belt, and a guide wall adjacent to the bushing. The belt is displaceable in the longitudinal direction relative to the bushing. The bushing includes a shoulder adjacent to the longitudinal end of the belt and a stem extending from the shoulder to an inside of the belt to support the belt. The guide guides the bushing to move in a direction opposite to a conveyance direction of the print medium when the belt moves toward the bushing. The stem of the bushing includes a convex portion that is in contact with an inner surface of the belt when the belt is displaced in the longitudinal direction.

Abstract: The present invention proposes a program production method or the like that is suitable for generating a program according to a change in situation. In a program production apparatus 3, a program production unit 21 generates a program using material data. A basic script storage unit 11 stores a basic script. In a stage in which the generation of the program is started, the program production unit 21 generates the program according to the basic script. Subsequently, the program production unit 21 gradually modifies the basic script using dynamic data (e.g., a user's instruction, information collected in a real-time manner, etc.), so as to generate a program suitable for the situation of the material data, viewers, or the like. This enables the provision of even live broadcasting with a small number of users. Also, this allows emergency broadcasting to be automatically provided according to situation.

Abstract: A fiber optic adapter for use with a fiber optic connector is provided. The fiber optic adapter indicates during installation of the connector when the connector is properly installed in the fiber optic adapter. The adapter includes a housing with a cavity at one end for receiving the fiber optic connector. The housing contains a sliding latch configured to contact the fiber optic connector when the fiber optic connector is inserted into the cavity. The sliding latch is movable within the housing from an extended position to a latched position. A connector latch in the housing is configured to engage the stop when the sliding latch is at the latched position. A spring is coupled to the sliding latch and is compressible during insertion of the fiber optic connector into the cavity. When the fiber optic connector is inserted into the cavity, the fiber optic adapter indicates when the sliding latch is not at the latched position.

Abstract: A method for producing a fluoropolymer which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a surfactant to provide a fluoropolymer, the surfactant being represented by the general formula (1): CR1R2R4—CR3R5—X-A, wherein R1 to R5 are each H or a monovalent substituent, with the proviso that at least one of R1 and R3 represents a group represented by the general formula: —Y—R6 and at least one of R2 and R5 represents a group represented by the general formula: —X-A or a group represented by the general formula: —Y—R6; and A is the same or different at each occurrence and is —COOM, —SO3M, or —OSO3M. Also disclosed is a surfactant for polymerization represented by the general formula (1), a method for producing a fluoropolymer using the surfactant and a composition including a fluoropolymer and the surfactant.

Abstract: A composition including a fluoropolymer and substantially free from a compound represented by the following formula (3): (H—(CF2)8—SO3)qM2, wherein M2 is H, a metal atom, NR54, imidazolium optionally containing a substituent, pyridinium optionally containing a substituent, or phosphonium optionally containing a substituent; R5s are each H or an organic group and are the same as or different from each other; and q is 1 or 2.

Abstract: A non-transitory computer-readable storage medium storing a search program that causes at least one computer to execute a process, the process includes searching for, as an answer of a combinatorial optimization problem, a first arrangement of a plurality of amino acids included in a medium molecule based on a value of a first cost arithmetic expression that does not make distinction between a L-form and a D-form of the plurality of amino acids; searching for, as the answer of the combinatorial optimization problem, a second arrangement of the plurality of amino acids based on a value of a second cost arithmetic expression that makes distinction between the L-form and the D-form of the plurality of amino acids by setting the first arrangement as an initial arrangement of searching; and outputting the second arrangement.

Abstract: Disclosed is a patch for alleviating cancerous pain. The patch is provided with a support layer and an adhesive layer laminated on the support layer. The adhesive layer contains an adhesive base and 150-225 mg of diclofenac sodium. One patch is used by being attached once per day.

Abstract: The present invention provides a patch for relieving lumbago, the patch comprising a backing and an adhesive layer laminated on the backing, wherein the adhesive layer comprises an adhesive base and 0.70 to 1.50 mg of diclofenac sodium per cm2 of application area, and the patch is used by applying the patch once a day to the chest region, the abdominal region, the dorsal region, the brachial region, or the femoral region of a human.