Abstract: The present invention provides an aptamer that binds to an autotaxin, which contains a nucleotide sequence represented by the following formula (I): CGGAACC-N1-GGTC??(I) wherein N1 shows any of 3 to 11 nucleotides, and a utilization method thereof.

Abstract: The present invention provides an aptamer binding to an autotaxin, which contains a nucleotide sequence represented by the formula: (SEQ ID NO: 42) GWAACAGGUUUUGCU wherein W is A or U (provided uracil is optionally thymine), and which is the following (a) or (b): (a) an aptamer wherein, in the nucleotides contained in the aptamer, (i) the 2?-position of the ribose of each pyrimidine nucleotide is a fluorine atom, (ii) the 2?-position of the ribose of each purine nucleotide is a hydroxy group; (b) the aptamer of (a), wherein (i) the fluorine atom at the 2?-position of the ribose of each pyrimidine nucleotide is independently unsubstituted, or substituted by an atom or group selected from the group consisting of a hydrogen atom, a hydroxy group and a methoxy group, (ii) the hydroxy group at the 2?-position of the ribose of each purine nucleotide is independently unsubstituted, or substituted by an atom or group selected from the group consisting of a hydrogen atom, a methoxy group a

Abstract: Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.

Abstract: Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.