Abstract: The present invention relates to a production method of 4-alkoxy-3-trifluoromethylbenzyl alcohol at a high conversion ratio, which can strictly suppress production of a byproduct by using DIBAL as a reducing agent.

Abstract: The present invention relates to a production method of 4-alkoxy-3-trifluoromethylbenzyl alcohol at a high conversion ratio, which can strictly suppress production of a byproduct by using DIBAL as a reducing agent.

Abstract: The invention provides a salt of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one and a crystal thereof. (R)-3-[2-(2-Hydroxymethylpyrrolidin-1-ypethyl]-5-methyl-2H-1-isoquinolin-1-one monophosphate is a compound which is chemically stable, has high solubility, and shows less weight change due to humidity as compared to a free form and monohydrochloride dihydrate, and is superior as a bulk drug for pharmaceutical products.

Abstract: The invention provides a salt of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one and a crystal thereof. (R)-3-[2-(2-Hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one monophosphate is a compound which is chemically stable, has high solubility, and shows less weight change due to humidity as compared to a free form and monohydrochloride dihydrate, and is superior as a bulk drug for pharmaceutical products.

Abstract: In a trim-tilt device for a marine propulsion unit 20, a cylinder 41 of a cylinder device 21 is covered with a tank 28 constituting a hydraulic fluid supply/discharge device 22 and a relief valve 131 is opened when hydraulic pressure of the tank 25 becomes higher than a fixed value, so that hydraulic fluid of the tank 25 can be relieved for the second tilt chamber 32B.

Abstract: A tilt device for a marine propulsion unit is disclosed where a shock blow valve comprises a disk valve fixed to a valve seat surface of the piston, the valve seat surface being provided with a seal member surrounding a communication hole which opens at the valve seat surface, and the disk valve is tightly connected to the seal member.

Abstract: In a trim-tilt device for a marine propulsion unit (20), a check valve (121) is provided for allowing a hydraulic fluid to flow from a pump (24) to a first trim chamber (32A) and a first tilt chamber (42A), and a relief valve (122), which is opened if the hydraulic pressure of the first trim chamber (32A) and the hydraulic pressure of the first tilt chamber (42A) become higher than a fixed value, are connect in parallel to a hydraulic fluid low passage (91) connecting a first trim chamber (32A) and a first tilt chamber (42A) to a pump (24).

Abstract: 2,2-Dideutero-5-aminolevulinic acid or its salt, or a hydrate or a solvate thereof, preferably 2,2-dideutero-5-aminolevulinic acid hydrochloride, and a process for preparing 2,2-dideutero-5-aminolevulinic acid are provided. The 2,2-Dideutero-5-aminolevulinic acid provided by the present invention is useful as a contrast medium for MRI diagnosis.

Abstract: Disclosed is a benzoylethylene derivative represented by the following formula (I) or a salt thereof. ##STR1## R.sup.1 to R.sup.5 : a hydrogen atom, --OR.sup.9 (R.sup.9 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc.), etc.,R.sup.6 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc.,R.sup.7 : a hydrogen atom, a cyano group, a C.sub.1 -C.sub.5 alkyl group, --SO.sub.q R.sup.15 (q: 0, 1, 2, R.sup.15 : a thienyl group, a phenyl group, etc.) etc.,R.sup.8 : a cyano group, --CR.sup.22 R.sup.23 X (R.sup.22, R.sup.23 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc., X: --NR.sup.24 R.sup.25 (R.sup.24, R.sup.25 : a C.sub.1 -C.sub.5 alkyl group, etc., an alkylene group by combining, etc.)), etc.The benzoylethylene derivative of the present invention has potent tyrosine kinase inhibiting activity and cancer cell growth inhibiting activity. The tyrosine kinase inhibitor of the present invention is useful as a carcinostatic agent.

Abstract: A pharmaceutical composition which comprises a pharmaceutically effective amount of a compound of the formula ##STR1## wherein R.sup.1 represents a hydrogen atom,R.sup.2 represents --(CH.sub.2).sub.m -Awherein m is an integer of 0 to 3, andA represents pyridyl which is unsubstituted or is substituted by C.sub.1 -C.sub.3 alkyl said alkyl being unsubstituted or substituted by phenyl, and R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently represent a hydrogen atom, a halogen atom, C.sub.1 -C.sub.5 alkyl which is unsubstituted or is substituted with a halogen atom or --OR.sup.13 wherein R.sup.13 represents a hydrogen atom or C.sub.1 -C.sub.5 alkyl which is unsubstituted or is substituted with a halogen atom or phenyl, or when their adjacent substituents are taken together, they represent C.sub.1 -C.sub.3 oxyalkylene having one or two oxygen atoms;or a pharmaceutically acceptable salt thereof, anda pharmaceutically acceptable carrier therefor.

Abstract: Styrene derivatives of the following general formula (I): ##STR1## or pharmaceutically acceptable salts thereof. A pharmaceutical composition useful as anticancer agent, which comprises the above compound as an essential component, is also provided.

Abstract: A tilt cylinder for tilting an outboard engine has first and second cylinder chambers. A pair of on/off valves is movably disposed in respective fluid passages connected to a hydraulic pump and the first and second cylinder chambers, respectively. The on/off valves are operatively combined with respective shuttle valves which have respective oil passages in facing relationship to the on/off valves, respectively, and respective ball valve bodies for selectively opening the oil passage into communication with each other. When the hydraulic pump is actuated to develop a working oil pressure buildup, one of the on/off valves is opened by the working oil pressure buildup to establish an oil supply passage from the hydraulic pump to one of the first and second chambers, and the other of the on/off valves is opened by the coacting shuttle valve which is moved by the working oil pressure buildup to establish an oil return passage from the other of the first and second chambers to the hydraulic pump.

Abstract: Novel acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the following general formula (I): ##STR1## [wherein R.sup.1 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group; R.sup.2 is a group of formula: --CHO, --CH.sub.2 OR.sup.3 or ##STR2## (wherein R.sup.3 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group; and R.sup.4 is C.sub.1 to C.sub.4 alkyl group) with the proviso that R.sup.1 and R.sup.3 do not represent the same substituents simultaneously; when R.sup.1 is a hydrogen atom, R.sup.3 is not acetyl group or tetrahydropyranyl group; and when R.sup.2 is a group of formula: ##STR3## R.sup.1 is not a hydrogen atom).

Abstract: A power steering device for steering an outboard engine on a small boat has a hydraulic cylinder unit for angularly moving a steering arm of the outboard engine, the hydraulic cylinder unit having a piston rod connected to the steering arm, and a directional control spool valve for supplying a hydraulic pressure to the hydraulic cylinder unit to move the piston rod. A control cable controls the directional control spool valve in response to operation of a steering wheel. The control cable has a core having an end coupled to the piston rod and a sheath covering the core and having an end coupled to the spool of the directional control spool valve. The hydraulic cylinder unit has a cylinder divided by a piston into a first oil chamber through which the piston rod extends and a second oil chamber remote from the piston rod.

Abstract: Acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the general formula (I): ##STR1##

Abstract: A spool valve includes a spool assembly axially movably disposed in a cylindrical valve case. The spool assembly comprises a guide sleeve threaded in an end portion of the valve case and having an inner end positioned in the valve case and an outer end positioned outside of the valve case, and a spool axially slidably extending through an opposite end portion of the valve case and the guide sleeve. The spool is centered with respect to the valve case by a self-centering mechanism which is retained in the guide sleeve and the spool by a stopper nut threaded in the inner end of the guide sleeve. A lock nut is threaded over the outer end of the guide sleeve for fastening the guide sleeve to the valve case.

Abstract: Acyclic terpene compounds useful as intermediates or producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the general formula (I): ##STR1##

Abstract: Acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the general formula (I): ##STR1##

Abstract: Novel monocyclic terpene derivative of the formula: ##STR1## wherein R is hydrogen atom, trimethylsilyl group or 1-ethoxyethyl group, and novel intermediates therefor. The terpene derivative (I) is a useful intermediate for preparing Sarcophytol A having an anti-carcinogenesis promoter activity and an antitumor activity.

Abstract: Acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promoter activity and anti-tumor activity, which compounds are shown by the general formula (I): ##STR1##