Patents by Inventor Hisao Takizawa

Hisao Takizawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same
    Patent number: 8759489
    Abstract: The present invention relates to an antibody that recognizes a first antibody, the antibody specifically recognizing one of a free first antibody and an antigen-binding first antibody. More specifically, the above antibody is a domino antibody that specifically recognizes and binds to an antigen-binding first antibody, or an antibody-unlocking antibody that specifically recognizes and binds to a free first antibody.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: June 24, 2014
    Assignees: Otsuka Pharmaceutical Co., Ltd., Tokyo University of Science
    Inventors: Takachika Azuma, Hisao Takizawa
  • ANTIBODY IDENTIFYING AN ANTIGEN-BOUND ANTIBODY AND AN ANTIGEN-UNBOUND ANTIBODY, AND METHOD FOR PREPARING THE SAME
    Publication number: 20120157663
    Abstract: The present invention relates to an antibody that recognizes a first antibody, the antibody specifically recognizing one of a free first antibody and an antigen-binding first antibody. More specifically, the above antibody is a domino antibody that specifically recognizes and binds to an antigen-binding first antibody, or an antibody-unlocking antibody that specifically recognizes and binds to a free first antibody.
    Type: Application
    Filed: August 24, 2011
    Publication date: June 21, 2012
    Inventors: Takachika AZUMA, Hisao TAKIZAWA
  • Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same
    Patent number: 8093018
    Abstract: The present invention relates to an antibody that recognizes a first antibody, the antibody specifically recognizing one of a free first antibody and an antigen-binding first antibody. More specifically, the above antibody is a domino antibody that specifically recognizes and binds to an antigen-binding first antibody, or an antibody-unlocking antibody that specifically recognizes and binds to a free first antibody.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: January 10, 2012
    Assignees: Otsuka Pharmaceutical Co., Ltd., Tokyo University of Science
    Inventors: Takachika Azuma, Hisao Takizawa
  • USES OF A GLYCOPROTEIN VI (GPVI) INHIBITOR
    Publication number: 20100297116
    Abstract: The present invention describes a method for reducing reperfusion injury and/or infarction by using an inhibitor of platelet GPVI. This method may be used to treat patients during or after a heart attack or elective cardiac surgery.
    Type: Application
    Filed: October 29, 2008
    Publication date: November 25, 2010
    Inventors: Yongge Liu, Narendra N. Tandon, Hisao Takizawa, Junichi Kambayashi
  • ANTIBODY IDENTIFYING AN ANTIGEN-BOUND ANTIBODY AND AN ANTIGEN-UNBOUND ANTIBODY, AND METHOD FOR PREPARING THE SAME
    Publication number: 20100040605
    Abstract: The present invention relates to an antibody that recognizes a first antibody, the antibody specifically recognizing one of a free first antibody and an antigen-binding first antibody. More specifically, the above antibody is a domino antibody that specifically recognizes and binds to an antigen-binding first antibody, or an antibody-unlocking antibody that specifically recognizes and binds to a free first antibody.
    Type: Application
    Filed: May 18, 2009
    Publication date: February 18, 2010
    Inventors: Takachika AZUMA, Hisao Takizawa
  • Glycoprotein VI antibodies and methods of use thereof
    Patent number: 7645592
    Abstract: The present invention describes antibodies generated against platelet membrane glycoprotein VI (GPVI), methods of producing the anti-GPVI antibodies, and the use of these antibodies as research, diagnostic and immunotherapeutic agents, in particular, as diagnostic and therapeutic agents for the detection and treatment of thrombosis and other vascular diseases.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: January 12, 2010
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hisao Takizawa, Yutaka Matsumoto, Narendra Nath Tandon, Keiji Okuyama
  • Glycoprotein VI antibodies and methods thereof
    Patent number: 7611707
    Abstract: The present invention describes antibodies generated against platelet membrane glycoprotein VI-(GPVI), methods of producing the anti-GPVI antibodies, and the use of these antibodies as research and immunotherapeutic agents, in particular, as antithrombotic therapeutic agents.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: November 3, 2009
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Narendra Nath Tandon, Yutaka Matsumoto, Hisao Takizawa, Keiji Okuyama
  • Glycoprotein VI antibodies and methods of use thereof
    Publication number: 20070207155
    Abstract: The present invention describes antibodies generated against platelet membrane glycoprotein VI (GPVI), methods of producing the anti-GPVI antibodies, and the use of these antibodies as research, diagnostic and immunotherapeutic agents, in particular, as diagnostic and therapeutic agents for the detection and treatment of thrombosis and other vascular diseases.
    Type: Application
    Filed: November 15, 2006
    Publication date: September 6, 2007
    Inventors: Hisao Takizawa, Yutaka Matsumoto, Narendra Tandon, Keiji Okuyama
  • Glycoprotein Vi Antibodies and Methods Thereof
    Publication number: 20070202108
    Abstract: The present invention describes antibodies generated against platelet membrane glycoprotein VI-(GPVI), methods of producing the anti-GPVI antibodies, and the use of these antibodies as research and immunotherapeutic agents, in particular, as antithrombotic therapeutic agents.
    Type: Application
    Filed: April 26, 2005
    Publication date: August 30, 2007
    Inventors: Narendra Tandon, Yutaka Matsumoto, Hisao Takizawa, Keiji Okuyama
  • Carbostyril derivatives for inhibiting production of interleukin-8
    Patent number: 5637597
    Abstract: The present invention provides agents for inhibiting production of interleukin-8 and for inhibiting granulocytes activation as well as novel method for curing inflamatory diseases. The agents for inhibiting production of interleukin-8, and for inhibiting granulocytes activation and for curing inflammatory diseases, which contains as an active ingredient, a carbostyril derivative represented by the general formula (I): ##STR1## where R is as described in the specification.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Takahide Matsuda, Shigeru Owada, Hiroshi Muta, Miki Aihara, Hisao Takizawa, Ken-ichi Imagawa, Mikio Kikuchi
  • Glycoprotein and gene coding therefor
    Patent number: 5521296
    Abstract: The present invention provides a glycoprotein derived from human cell membrane, which has a molecular weight of 20 to 25 Kd as estimated by SDS polyacrylamide gel electrophoresis, and contains N-glycoside type carbohydrate chain and phosphatidylinositol, and possesses an inhibitory activity to complement-mediated cell membrane damage. The present invention further provides a gene coding for the glycoprotein, and a method for the production of the glycoprotein and the gene therefor.
    Type: Grant
    Filed: August 1, 1991
    Date of Patent: May 28, 1996
    Assignees: Hidechika Okada, Mitsubishi Kasei Corp.
    Inventors: Hidechika Okada, Noriko Okada, Yoichi Nagami, Kazuhiro Takahashi, Hisao Takizawa, Jun Kondo
  • Glycoprotein and gene coding therefor
    Patent number: 5179198
    Abstract: The present invention provides a glycoprotein derived from human cell membrane, which has a molecular weight of 20 to 25 Kd as estimated by SDS polyacrylamide gel electrophoresis, and contains N-glycoside type carbohydrate chain and phosphatidylinositol, and possesses an inhibitory activity to complement-mediated cell membrane damage. The present invention further provides a gene coding for the glycoprotein, and a method for the production of the glycoprotein and the gene therefor.
    Type: Grant
    Filed: July 7, 1989
    Date of Patent: January 12, 1993
    Assignees: Hidechika Okada, Mitsubishi Corporation
    Inventors: Hidechika Okada, Noriko Okada, Yoichi Nagami, Kazuhiro Takahashi, Hisao Takizawa, Jun Kondo