Patents by Inventor Hisashi Nakashima
Hisashi Nakashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190111589Abstract: A gas venting/introducing structure (1) including a body (2) and a porous portion (3) integrated with the body (2) having a plurality of gas venting/introducing paths (4) each in communication with the porous portion (3) at one end. The plurality of gas venting/introducing paths 4 are open to the outside of the body (2) at other ends thereof such that at least two gas venting/introducing paths (4) merge into a single path (5). The body (2) is made of a porous metal denser than the material of the porous portion (3). The gas venting/introducing paths (4) each has an inner wall (4a) defined by a smooth surface. The distance between a communication side (3a) of the porous portion (3) and an opposite side (3b) is on the order of 4 mm. A concavity is formed at the communication part between the gas venting/introducing paths (4) and the porous portion (3).Type: ApplicationFiled: March 16, 2017Publication date: April 18, 2019Applicant: SANKO GOSEI LTD.Inventors: Toshio MITSUSHIMA, Hisashi NAKASHIMA
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Patent number: 8252781Abstract: [Object] It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome). [Means to Solve the Object] A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: GrantFiled: October 28, 2009Date of Patent: August 28, 2012Assignee: Kowa Company, Ltd.Inventors: Hisashi Nakashima, Takaaki Araki, Takahisa Ogamino, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya
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Patent number: 8236789Abstract: It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: GrantFiled: August 28, 2009Date of Patent: August 7, 2012Assignee: Kowa Company, Ltd.Inventors: Hisashi Nakashima, Takahiro Mori, Ryoko Mori, legal representative, Takaaki Araki, Takahisa Ogamino, Kazutoyo Abe, Tadaaki Ohgiya
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Publication number: 20100144694Abstract: [Object] It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome). [Means to Solve the Object] A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: October 28, 2009Publication date: June 10, 2010Applicant: KOWA COMPANY, LTD.Inventors: Hisashi Nakashima, Takaaki Araki, Takahisa Ogamino, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya
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Publication number: 20100075943Abstract: It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: August 28, 2009Publication date: March 25, 2010Applicant: KOWA COMPANY, LTD.,Inventors: Hisashi Nakashima, Takahiro Mori, Takaaki Araki, Takahisa Ogamino, Kazutoyo Abe, Tadaaki Ohgiya, Ryoko Mori
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Publication number: 20100022572Abstract: It is to provide a novel compound useful for preventing and/or treating diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. A spiro compound represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: July 16, 2009Publication date: January 28, 2010Applicant: KOWA COMPANY, LTD.Inventors: Hisashi Nakashima, Takahisa Ogamino, Takaaki Araki, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya, Kimiyuki Shibuya
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Publication number: 20090289136Abstract: To provide a lid body for a disposer apparatus which can keep inside of the disposer apparatus clean with ease. A washing-agent-reception portion is provided on a side of a rear surface of the lid body and at an inside of the body portion. The washing-agent-reception portion receives a washing agent package. When changing over drive of the disposer apparatus to a crushing operation for crushing garbage, water supply into the inside of the hopper starts concurrently with the crushing of the garbage by the crushing unit. Water to be supplied is supplied to the inside of the hopper through the lid body as a pathway thereof. At this time, the water passing through the lid body is supplied to the inside of the hopper as washing liquid with it dissolving washing agent. When driving the crushing unit, washing of the inside of the hopper is executed by the washing liquid concurrently with the crushing operation, which keeps the inside of the hopper clean.Type: ApplicationFiled: July 4, 2007Publication date: November 26, 2009Applicant: MAX CO., LTD.Inventors: Tetsuo Ishikawa, Toshio Hiranuma, Hisashi Nakashima
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Publication number: 20080306102Abstract: A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11?-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11?-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).Type: ApplicationFiled: May 16, 2008Publication date: December 11, 2008Applicant: KOWA CO., LTD.Inventors: Hisashi NAKASHIMA, Takaaki ARAKI, Takahisa OGAMINO, Yasushi KANEKO, Kazutoyo ABE, Kimiyuki SHIBUYA, Tadaaki OHGIYA
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Patent number: 6478079Abstract: A recess portion for setting an attachment position is formed in each plate fin at positions adjacent to both longitudinal ends of the plate fins on both upstream and downstream ends in an air flowing direction. Therefore, air passing through the plate fins is disturbed by a standing wall portion of the recess portion around the longitudinal ends of the plate fins. Thus, it can prevent a thermal boundary layer from being expanded in a heat exchanger having the plate fin, and heat-transmission efficiency can be improved in the heat exchanger. As a result, an entire area of the plate fin can be effectively used, thereby improving heat-exchanging capacity of the heat exchanger.Type: GrantFiled: August 16, 1999Date of Patent: November 12, 2002Assignees: Denso Corporation, Hidaka Seiki Kabushiki KaishaInventors: Seiichi Kato, Hisashi Nakashima, Akio Ueda, Masakazu Hyodo, Fumio Moriyama
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Patent number: 6427769Abstract: A heat exchanger has a tank for accommodating a heat medium therein and a tube connected to the tank through a core plate. Specifically, an end portion of the tube is inserted into a connection hole of the core plate and is mechanically joined thereto. A joined portion of the tube and the core plate is covered with adhesive through a wettability improving film for improving wettability of the adhesive to the joined portion. As a result, a sealing property between the tube and the core plate is easily and stably improved by the adhesive.Type: GrantFiled: June 3, 1999Date of Patent: August 6, 2002Assignee: Denso CorporationInventors: Kouji Horie, Seiichi Kato, Hisashi Nakashima
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Patent number: 6298910Abstract: A heat exchanger has a core portion composed of several pairs of first and second plates laminated with and brazed to one another. Each of the first and second plates is composed a core member, a brazing filler layer formed on a surface of the core member, and a sacrifice layer formed on the other surface of the core member. For instance, to form a pair of the first and second plates, the first plate is formed with a convex portion with an opening portion, and a burring portion of the second plate is inserted into the opening portion and is plastically deformed such that the sacrifice layer of the second plate closely contacts the brazing filler metal layer of the first plate. Then the first and the second plates are brazed together.Type: GrantFiled: September 25, 2000Date of Patent: October 9, 2001Assignee: Denso CorporationInventors: Shuji Komoda, Hisashi Nakashima, Shinichi Hamada
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Publication number: 20010025706Abstract: A heat exchanger has a tank for accommodating a heat medium therein and a tube connected to the tank through a core plate. Specifically, an end portion of the tube is inserted into a connection hole of the core plate and is mechanically joined thereto. A joined portion of the tube and the core plate is covered with adhesive through a wettability improving film for improving wettability of the adhesive to the joined portion. As a result, a sealing property between the tube and the core plate is easily and stably improved by the adhesive.Type: ApplicationFiled: June 3, 1999Publication date: October 4, 2001Inventors: KOUJI HORIE, SEIICHI KATO, HISASHI NAKASHIMA
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Patent number: 6082439Abstract: In a mechanically assembled type heat exchanger, in which an end portion of an oval tube is inserted into a barring hole of a core plate and expanded to be press fit to the core plate. Then adhesive is potted on the core plate for sealing the press fit portion in the end of the tube. A reinforcing member is formed around the barring hole for increasing the rigidity of the core plate so as to improve the durability of sealing.Type: GrantFiled: November 26, 1997Date of Patent: July 4, 2000Assignee: Denso CorporationInventors: Seiichi Kato, Hisashi Nakashima, Sumio Susa
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Patent number: 6053629Abstract: A vibration generating device is provided. Where a bucket link is replaced by the vibration generating device, the vibration generating device is connected to a main operating valve by conduits. Since both flow rate control valve and fluid motor are housed within a casing, a high pressure conduit for connecting the vibration generating device and main operating valve is not necessitated, thereby making the structure compact, and making the working of conduit arrangement easy and improve reliability. The center axial line of the cylinder chamber, rotary axial line of the valve element of the rotary valve and center axial line of the valve element of the flow rate valve are made parallel to one another so that these cylinder chamber, rotary valve and flow rate control valve are arranged in a superposing fashion, thereby making the entire vibration generating device compact.Type: GrantFiled: October 13, 1998Date of Patent: April 25, 2000Assignee: Teijin Seiki Co., Ltd.Inventor: Hisashi Nakashima
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Patent number: 5282363Abstract: A hydraulic circuit for running a crawler vehicle which comprises a running frame portion provided with motors for running the crawler vehicle and an upper swivel portion turnably disposed on the running frame portion via a swivel joint. Electro-magnetic proportional flow directional control valve (a directional control valves) (15) for controlling the running motors are disposed between the swivel joint (41) and the running motors (19). The number of the high pressure passages in the swivel joint (41) can be reduced, because of increase of pressure resistance, the size of the swivel joint can be small, and accordingly, the hydraulic circuit for running a crawler vehicle can be inexpensive, and possibility for leakage of pressure oil becomes low.Type: GrantFiled: December 31, 1991Date of Patent: February 1, 1994Assignee: Teijin Seiki Co., Ltd.Inventors: Kazunori Ogawa, Takuma Endo, Hisashi Nakashima, Yoji Asano