Patents by Inventor Hisayoshi Okazaki
Hisayoshi Okazaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4943645Abstract: A novel benzoquinone derivative of the general formula: ##STR1## [wherein R.sub.1 and R.sub.2 are the same or different and each is methyl or methoxy; n is an integer of 0 to 21; m is 0 or 1, Z is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen or an alkyl group which may optionally be substituted or, R.sub.3 and R.sub.4 together with the adjacent nitrogen atom form a morpholino group), a group of the formula: --COR.sub.5 (wherein R.sub.5 is an .alpha.-amino acid residue or a substituted or unsubstituted glucosamine residue), a group of the formula: ##STR3## (wherein R.sub.6 is a divalent hydrocarbon group of 1 to 3 carbon atoms), a group of the formula: ##STR4## (wherein R.sub.6 has the same meaning as defined above) or a group of the formula: ##STR5## (wherein l is an integer of 1 to 4 and R.sub.Type: GrantFiled: August 8, 1989Date of Patent: July 24, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Hisayoshi Okazaki, Isuke Imada
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Patent number: 4874752Abstract: A novel benzoquinone derivative of the general formula: ##STR1## [wherein R.sub.1 and R.sub.2 are the same or different and each is methyl or methoxy; n is an integer of 0 to 21; m is 0 or 1, Z is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen or an alkyl group which may optionally be substituted or, R.sub.3 and R.sub.4 together with the adjacent nitrogen atom form a morpholino group), a group of the formula: --COR.sub.5 (wherein R.sub.5 is an .alpha.-amino acid residue or a substituted or unsubstituted glucosamine residue), a group of the formula: ##STR3## (wherein R.sub.6 is a divalent hydrocarbon group of 1 to 3 carbon atoms), a group of the formula: ##STR4## (wherein R.sub.6 has the same meaning as defined above) or a group of the formula: --CH.dbd.CH).sub.l COR.sub.7 (wherein l is an integer of 1 to 4 and R.sub.Type: GrantFiled: November 8, 1988Date of Patent: October 17, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Hisayoshi Okazaki, Isuke Imada
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Patent number: 4808339Abstract: A novel benzoquinone derivative of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is methyl or methoxy; n is an integer of 0 to 21; m is 0 or 1, Z is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen or an alkyl group which may optionally be substituted or, R.sub.3 and R.sub.4 together with the adjacent nitrogen atom form a morpholino group), a group of the formula: --COR.sub.5 (wherein R.sub.5 is an .alpha.-amino acid residue or a substituted or unsubstituted glucosamine residue), a group of the formula: ##STR3## (wherein R.sub.6 is a divalent hydrocarbon group of 1 to 3 carbon atoms), a group of the formula: ##STR4## (wherein R.sub.6 has the same meaning as defined above) or a group of the formula: ##STR5## (wherein l is an integer of 1 to 4 and R.sub.Type: GrantFiled: March 18, 1988Date of Patent: February 28, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Hisayoshi Okazaki, Isuke Imada
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Patent number: 4751303Abstract: A novel benzoquinone derivative of the general formula: ##STR1## [wherein R.sub.1 and R.sub.2 are the same or different and each is methyl or methoxy; n is an integer of 0 to 21; m is 0 or 1, Z is a group of the formula: (wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen or an alkyl group which may optionally be substituted or, R.sub.3 and R.sub.4 together with the adjacent nitrogen atom form a morpholino group), a group of the formula: --COR.sub.5 (wherein R.sub.5 is an .alpha.-amino acid residue or a substituted or unsubstituted glucosamine residue), a group of the formula: ##STR2## (wherein R.sub.6 is a divalent hydrocarbon group of 1 to 3 carbon atoms), a group of the formula: ##STR3## (wherein R.sub.6 has the same meaning as defined above) or a group of the formula: --CH.dbd.CH).sub.l COR.sub.7 (wherein l is an integer of 1 to 4 and R.sub.Type: GrantFiled: March 28, 1985Date of Patent: June 14, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Hisayoshi Okazaki, Isuke Imada
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Patent number: 4569943Abstract: The compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, methyl or hydroxymethyl, R.sub.2 is hydrogen or methoxy, R.sub.3 is hydroxy or methoxy, and R.sub.4 is hydrogen or a group ##STR2## is novel, and the compound is of use as inhibitors of animal tissue fibrosis, or biochemical reagents.Type: GrantFiled: October 19, 1983Date of Patent: February 11, 1986Assignee: Takeda Chemical Industries, Ltd.Inventors: Hisayoshi Okazaki, Kazuhiko Ohta, Takenori Ishimaru
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Patent number: 4526719Abstract: A novel benzoquinone derivative of the general formula: ##STR1## [wherein R.sub.1 and R.sub.2 are the same or different and each is methyl or methoxy; n is an integer of 0 to 21; m is 0 or 1, Z is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen or an alkyl group which may optionally be substituted or, R.sub.3 and R.sub.4 together with the adjacent nitrogen atom form a morpholino group), a group of the formula: --COR.sub.5 (wherein R.sub.5 is an .alpha.-amino acid residue or a substituted or unsubstituted glucosamine residue), a group of the formula: ##STR3## (wherein R.sub.6 is a divalent hydrocarbon group of 1 to 3 carbon atoms), a group of the formula: ##STR4## (wherein R.sub.6 has the same meaning as defined above) or a group of the formula: --CH.dbd.CH.sub.l --COR.sub.7 (wherein l is an integer of 1 to 4 and R.sub.Type: GrantFiled: April 12, 1983Date of Patent: July 2, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Hisayoshi Okazaki, Isuke Imada
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Patent number: 4260599Abstract: An antifibrotic substance P-1894B is produced by cultivating a microorganism belonging to the genus Streptomyces and being capable of producing P-1894B in a culture medium to have Antifibrotic substance P-1894B elaborated and accumulated in the cultured broth and recovering the substance.P-1894B is effective for the prophylaxis or treatment of the fibrosis due to excessive collagen accumulation in mammal.Type: GrantFiled: July 26, 1979Date of Patent: April 7, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Hisayoshi Okazaki, Tsuneo Kanamaru, Kazuhiko Ohta
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Patent number: 4248892Abstract: Compounds of the formula ##STR1## wherein n is equal to zero or 1 and their physiologically acceptable salts are effective for the prophylaxis or treatment of the fibrosis due to excessive collagen accumulation in mammal.Type: GrantFiled: June 7, 1979Date of Patent: February 3, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Tsuneo Kanamaru, Takenori Ishimaru, Hisayoshi Okazaki
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Patent number: 4028185Abstract: Calcium cis-epoxysuccinate whose average particle size is not larger than 100 micron is converted into calcium L(+)-tartarate by a microorganism in a high concentration and in a better yield. This process is accelerated in the presence of a nonionic type surfactant of the medium.Type: GrantFiled: May 6, 1976Date of Patent: June 7, 1977Assignee: Takeda Chemical Ind., Ltd.Inventors: Yoshio Kamatani, Hisayoshi Okazaki, Ko Imai, Noriaki Fujita, Yoshio Yamazaki, Katsuhiko Ogino
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Patent number: 4013509Abstract: Calcium cis-epoxysuccinate is converted into calcium L(+)-tartarate by a microorganism in a high concentration and is a better yield. This process is accelerated in the presence of a nonionic type surfactant of the medium.Type: GrantFiled: January 19, 1976Date of Patent: March 22, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshio Kamatani, Hisayoshi Okazaki, Ko Imai, Noriaki Fujita, Yoshio Yamazaki, Katsuhiko Ogino
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Patent number: 4011135Abstract: L(+)-tartaric acid is produced in a high efficiency from cis-epoxysuccinic acid by a microorganism belonging to the genus Pseudomonas, Agrobacterium or Rhizobium.Type: GrantFiled: January 19, 1976Date of Patent: March 8, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshio Kamatani, Hisayoshi Okazaki, Ko Imai, Noriaki Fujita, Yoshio Yamazaki, Katsuhiko Ogino
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Patent number: RE34414Abstract: The compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, methyl or hydroxymethyl, R.sub.2 is hydrogen or methoxy, R.sub.3 is hydroxy or methoxy, and R.sub.4 is hydrogen or a group ##STR2## is novel, and the compound is of use as inhibitors of animal tissue fibrosis, or biochemical reagents.Type: GrantFiled: April 22, 1991Date of Patent: October 19, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Hisayoshi Okazaki, Kazuhiko Ohta, Takenori Ishimaru