Patents by Inventor Hisayuki Matsuo
Hisayuki Matsuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9938332Abstract: The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 12, 2012Date of Patent: April 10, 2018Inventors: Kenji Kangawa, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Patent number: 9573986Abstract: The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 22, 2010Date of Patent: February 21, 2017Assignee: KENJI KANGAWAInventors: Kenji Kangawa, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Patent number: 8524871Abstract: The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 31, 2011Date of Patent: September 3, 2013Inventors: Kenji Kangawa, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Publication number: 20130172251Abstract: The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 12, 2012Publication date: July 4, 2013Inventors: Kenji KANGAWA, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Patent number: 8227570Abstract: The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 30, 2008Date of Patent: July 24, 2012Inventors: Kenji Kangawa, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Publication number: 20110184153Abstract: The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 31, 2011Publication date: July 28, 2011Inventors: Kenji Kangawa, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Publication number: 20100240866Abstract: The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 22, 2010Publication date: September 23, 2010Inventors: KENJI KANGAWA, MASAYASU KOJIMA, HIROSHI HOSODA, HISAYUKI MATSUO, YOSHIHARU MINAMITAKE
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Publication number: 20090170763Abstract: The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: January 30, 2008Publication date: July 2, 2009Inventors: Kenji Kangawa, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Publication number: 20090105464Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heart failure, and acute and chronic renal failure.Type: ApplicationFiled: April 19, 2007Publication date: April 23, 2009Applicants: DAIICHI PURE CHEMICALS CO., LTD., DAIICHI PHARMACEUTICAL CO., LTD., Hisayuki MatsuoInventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
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Patent number: 7385026Abstract: The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 24, 2000Date of Patent: June 10, 2008Inventors: Kenji Kangawa, Masayasu Kojima, Hiroshi Hosoda, Hisayuki Matsuo, Yoshiharu Minamitake
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Patent number: 7211380Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.Type: GrantFiled: February 7, 1994Date of Patent: May 1, 2007Assignees: Shionogi & Co., Ltd.Inventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
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Publication number: 20030162710Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.Type: ApplicationFiled: January 3, 2003Publication date: August 28, 2003Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
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Patent number: 6602681Abstract: A C-terminal &agr;-amidating enzyme of Xenopus laevis and precursor thereof produced by a recombinant DNA technique; a DNA coding for the enzyme or precursor thereof; a plasmid containing the DNA; a host organism transformed with the plasmid; a process for production of the enzyme using the transformant; and a process for production of a C-terminal &agr;-amidated peptide using the enzyme.Type: GrantFiled: April 25, 1997Date of Patent: August 5, 2003Assignees: Daiichi Suntory Pharma Co., Ltd.Inventors: Kazuhiro Ohsuye, Katsuhiko Kitano, Shoji Tanaka, Hisayuki Matsuo, Kensaku Mizuno
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Publication number: 20020086843Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.Type: ApplicationFiled: July 11, 2001Publication date: July 4, 2002Applicant: Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
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Patent number: 6262232Abstract: A C-terminal &agr;-amidating enzyme of Xenopus laevis and precursor thereof produced by a recombinant DNA technique; a DNA coding for the enzyme or precursor thereof; a plasmid containing the DNA; a host organism transformed with the plasmid; a process for production of the enzyme using the transformant; and a process for production of a C-terminal &agr;-amidated peptide using the enzyme.Type: GrantFiled: July 15, 1988Date of Patent: July 17, 2001Assignees: Suntory Limited, Hisayuki MatsuoInventors: Kazuhiro Ohsuye, Katsuhiko Kitano, Shoji Tanaka, Hisayuki Matsuo, Kensaku Mizuno
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Patent number: 6245887Abstract: A C-terminal &agr;-amidating enzyme of Xenopus laevis and precursor thereof produced by a recombinant DNA technique; a DNA coding for the enzyme or precursor thereof; a plasmid containing the DNA; a host organism transformed with the plasmid; a process for production of the enzyme using the transformant; and a process for production of a C-terminal &agr;-amidated peptide using the enzyme.Type: GrantFiled: April 16, 1990Date of Patent: June 12, 2001Assignee: Suntory LimitedInventors: Kazuhiro Ohsuye, Katsuhiko Kitano, Shoji Tanaka, Hisayuki Matsuo, Kensaku Mizuno
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Patent number: 6034231Abstract: The gene of a human CNP (human C-type natriuretic peptide), as well as the hCNP precursor protein that is encoded by said gene. The hCNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Ala Glu Glu Leu - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - Met Ser Gly Leu Gly Cys.The hCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.Type: GrantFiled: September 26, 1991Date of Patent: March 7, 2000Assignee: Suntory LimitedInventors: Shoji Tanaka, Kayoko Fuchimura, Yasunori Tawaragi, Hisayuki Matsuo, Kenji Kanagawa, Naoto Minamino
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Patent number: 6020168Abstract: The gene and cDNA of a procine derived CNP (C-type natriuretic peptide), and a procine derived CNP precursor protein and derivatives thereof are disclosed. The proceine derivative CNP precursor is represented by the following amino acid sequence:Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly SerThese derivatives are novel and have natriuretic and hypotensive activities.Type: GrantFiled: July 12, 1991Date of Patent: February 1, 2000Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino, Shoji Tanaka, Kayoko Fuchimura, Yasunori Tawaragi
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Patent number: 5973134Abstract: A cDNA coding for a rat derived CNP (rCNP: C-type natriuretic pepteide), and a rat derived CNP precursor protein and derivatives thereof are disclosed.The rat derived CNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly CysThe rCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.Type: GrantFiled: September 11, 1991Date of Patent: October 26, 1999Assignees: Suntory Limited, Hasayuki MatsuoInventors: Hisayuki Matsuo, Masayasu Kojima, Kenji Kangawa, Naoto Minamito
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Patent number: 5910416Abstract: Adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.Type: GrantFiled: January 7, 1998Date of Patent: June 8, 1999Assignees: Shionogi & Co., Ltd., Kenji KangawaInventors: Kazuo Kitamura, Kenji Kangawa, Hisayuki Matsuo, Tanenao Eto