Abstract: A pressure sensor has a stem in which a pressure introduction hole into which a pressure medium is introduced and a diaphragm deformable according to the pressure of the pressure medium are formed, and a strain detecting element which is arranged on the diaphragm via an insulating film and being configured to output a detection signal according to the deformation of the diaphragm. The strain detecting element is configured to have a portion made of polysilicon. A low doping layer having a higher electrical resistivity than polysilicon and a higher crystallinity than the insulating film is arranged between the insulating film and the strain detecting element.

Abstract: The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).

Abstract: A pressure sensor has a stem in which a pressure introduction hole into which a pressure medium is introduced and a diaphragm deformable according to the pressure of the pressure medium are formed, and a strain detecting element which is arranged on the diaphragm via an insulating film and being configured to output a detection signal according to the deformation of the diaphragm. The strain detecting element is configured to have a portion made of polysilicon. A low doping layer having a higher electrical resistivity than polysilicon and a higher crystallinity than the insulating film is arranged between the insulating film and the strain detecting element.

Abstract: The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

Abstract: The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

Abstract: The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

Abstract: The present invention provides a pharmaceutical composition for respiratory administration containing a polysaccharide derivative having a group derived from a polysaccharide and a group derived from a physiologically active substance that is covalently bonded to the group derived from a polysaccharide.

Abstract: The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

Abstract: The pressure sensor of the type having a pressure transmitting member transmitting a pressure received by a pressure-receiving diaphragm to a sensor chip is provided with a heat radiating member. This heat radiating member substantially suppresses the heat transferring from the pressure-receiving diaphragm to the sensor chip, to thereby preventing the pressure sensor from malfunction.

Abstract: A misfire in a combustion chamber of an internal combustion engine is detected by measuring a combustion chamber temperature with a temperature sensor element without using a pressure sensor having a low heat-resistive property. A temperature sensor includes an elongated probe portion extending from a housing. The housing is mounted on an engine so that the probe portion is exposed to the combustion chamber. A diaphragm is disposed on a tip of the probe portion, and a sensor element such as a thin film thermistor is mounted on the diaphragm, preferably on a rear surface of the diaphragm where the sensor element is not directly exposed to mixture gas in the combustion chamber. The sensor element may be embedded in the diaphragm. The probe portion of the temperature sensor may be integrally formed in a spark plug thereby to save a space for mounting the temperature sensor on the engine.

Abstract: A method for manufacturing a pressure detector includes the steps of: preparing a first member including a sensing portion, a second member including a pressure receiving diaphragm, and a pressure transmission member; inserting the pressure transmission member between the sensing portion and the pressure receiving diaphragm; applying a preliminary load to the sensing portion; connecting the first member and the second member under the preliminary load; monitoring a signal from the sensing portion, corresponding to the preliminary load; and determining the preliminary load on the basis of the electric signal monitored in the step of monitoring.

Abstract: A pressure sensor is attached to an engine by inserting a cylindrical metal case having a hollow part into an attaching hole formed in the engine in which engine oil flows. An oil passage is formed in the cylindrical metal case, and oil passages are formed in the housing. The pressure sensor is connected to the engine through an oil transmitting pipe and an oil returning pipe in order to radiate thermal energy of a pressure sensing diaphragm and a pressure sensing chip by flowing the engine oil from the engine to the hollow part of the metal case and by returning the engine oil from the hollow part to the engine.

Abstract: A pressure sensor is attached to an engine by inserting a cylindrical metal case having a hollow part into an attaching hole formed in the engine in which engine oil flows. An oil passage is formed in the cylindrical metal case, and oil passages are formed in the housing. The pressure sensor is connected to the engine through an oil transmitting pipe and an oil returning pipe in order to radiate thermal energy of a pressure sensing diaphragm and a pressure sensing chip by flowing the engine oil from the engine to the hollow part of the metal case and by returning the engine oil from the hollow part to the engine.

Abstract: The pressure sensor of the type having a pressure transmitting member transmitting a pressure received by a pressure-receiving diaphragm to a sensor chip is provided with a heat radiating member. This heat radiating member substantially suppresses the heat transferring from the pressure-receiving diaphragm to the sensor chip, to thereby preventing the pressure sensor from malfunction.

Abstract: A method for manufacturing a pressure detector includes the steps of: preparing a first member including a sensing portion, a second member including a pressure receiving diaphragm, and a pressure transmission member; inserting the pressure transmission member between the sensing portion and the pressure receiving diaphragm; applying a preliminary load to the sensing portion; connecting the first member and the second member under the preliminary load; monitoring a signal from the sensing portion, corresponding to the preliminary load; and determining the preliminary load on the basis of the electric signal monitored in the step of monitoring.