Patents by Inventor Hitoshi Minamino

Hitoshi Minamino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
    Patent number: 6037452
    Abstract: Factor VIIIC:vWF, Factor VIII C, Factor IX or Factor IX or the activated co-factors thereof are covalently linked to a poly(alkylene oxide).
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: March 14, 2000
    Assignee: Alpha Therapeutic Corporation
    Inventors: Hitoshi Minamino, Edward H. Mealey
  • Method of preparing foreign protein in yeast, recombinant DNA, transformant
    Patent number: 5503993
    Abstract: A method for preparing foreign protein in yeast using an expression recombinant DNA comprising DNA encoding the serum albumin signal peptide adjacent to DNA encoding the foreign protein is disclosed.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: April 2, 1996
    Assignee: The Green Cross Corporation
    Inventors: Naofumi Hayasuke, Yukimitsu Nakagawa, Yutaka Ishida, Ken Okabayashi, Kohji Murakami, Kiyoshi Tsutsui, Kazuo Ikegaya, Hitoshi Minamino, Sadao Ueda, Haruhide Kawabe, Hirofumi Arimura, Atusi Masaki
  • DNA's encoding signal peptides
    Patent number: 5409815
    Abstract: Novel signal peptides capable of functioning in yeasts have the amino acid sequence:Met-A.sub.1 -A.sub.2 -X-B-C-D-E-Fwherein A.sub.1 is a peptide chain composed of 1-3 amino acids each selected from the group consisting of Arg, Ser, Lys and His, A.sub.2 is a peptide chain composed of 1-3 amino acids, X is a peptide chain composed of 8-10 hydrophobic amino acids, B is Pro or Ser, C is Gly or Pro, D Cys, Ala, Leu, Ser, Thr and Val, E is Trp or Gln and F is Ala or Gly. DNA sequences coding for these signal peptides can be used for the secretory expression of heterologous proteins in yeasts.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: April 25, 1995
    Assignee: The Green Cross Corporation
    Inventors: Yukimitsu Nakagawa, Naofumi Hayasuke, Atsushi Masaki, Yutaka Ishida, Kohji Murakami, Ken Okabayashi, Kiyoshi Tsutsui, Hitoshi Minamino, Kazuo Ikegaya, Kaoru Kobayashi, Haruhide Kawabe, Sadao Ueda