Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.

Abstract: According to one embodiment, a display device includes a semiconductor layer, a first insulating layer, a gate electrode, a second insulating layer and a plurality of transparent conductive layers. The transparent conductive layers include a pixel electrode, a first conductive layer and a second conductive layer. The pixel electrode is in contact with the second conductive layer. The second conductive layer is in contact with the first conductive layer. The first conductive layer is brought into contact with a second region of the semiconductor layer through a first contact hole.

Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.

Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.

Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.

Abstract: A heater includes a heat generation element which includes a heater wire which spreads in a planar manner, and a metal plate serving as a heat dissipation element which includes a material having a high thermal conductivity, which is placed on a vehicle windowpane side of the heat generation element, which is heated by heat from the heat generation element, and which irradiates heat to the vehicle windowpane side. The vehicle windowpane is heated by the heat irradiated from the metal plate serving as the heat dissipation element.

Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.

Abstract: Provided is a vibration damping device that reduces parts cost and improves productivity. The vibration damping device includes: a mounting member (10) that is attached to a vibration source; a holder (20) that is attached to a vibration receiver; and an insulator (30) that connects the mounting member (10) with the holder (20), wherein the holder (20) has a base portion (21) to which an end of the insulator (30) is coupled and a stopper portion (22) that rises from the base portion (21), and the insulator (30) has a pair of rubber feet (31 a, 31 b) that faces each other at a distance, wherein the pair of rubber feet (31a, 31 b) defines a cavity (35) therebetween, and the base portion (21) has an opening (25) formed therein at a position corresponding to the cavity (35).

Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and [Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.

Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and ??[Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.

Abstract: A heater includes a heat generation element which includes a heater wire which spreads in a planar manner, and a metal plate serving as a heat dissipation element which includes a material having a high thermal conductivity, which is placed on a vehicle windowpane side of the heat generation element, which is heated by heat from the heat generation element, and which irradiates heat to the vehicle windowpane side. The vehicle windowpane is heated by the heat irradiated from the metal plate serving as the heat dissipation element.

Abstract: Provided is a vibration damping device that reduces parts cost and improves productivity. The vibration damping device includes: a mounting member (10) that is attached to a vibration source; a holder (20) that is attached to a vibration receiver; and an insulator (30) that connects the mounting member (10) with the holder (20), wherein the holder (20) has a base portion (21) to which an end of the insulator (30) is coupled and a stopper portion (22) that rises from the base portion (21), and the insulator (30) has a pair of rubber feet (31 a, 31 b) that faces each other at a distance, wherein the pair of rubber feet (31a, 31 b) defines a cavity (35) therebetween, and the base portion (21) has an opening (25) formed therein at a position corresponding to the cavity (35).

Abstract: The onium salt of the present invention contains predetermined compound A represented by the general formula (1). The composition of the present invention contains the onium salt of the present invention, and an onium salt containing predetermined compound B represented by the general formula (2). The onium salt and the composition of the present invention exert well-balanced excellent physical properties in terms of cold curing properties, storage stability, thermal shock resistance after curing, and moisture resistance.

Abstract: A wire (12) is wound around multiple processing rollers (11) several times. A holding mechanism (13) and a depressing mechanism (25) are provided above an area where the wire (12) is wound. The holding mechanism (13) holds a workpiece (W) elastically and laterally. The depressing mechanism (25) depresses the workpiece (W) held by the holding mechanism (13) toward the wire (12).

Abstract: A large ring part of a torque rod includes an outer frame section, an inner member, an intermediate ring and an elastic vibration isolating main body. The outer frame section and the intermediate ring are integrally combined with the elastic vibration isolating main body. An inner clearance is provided between the intermediate ring and the inner member such as to surround the circumference of the inner member. The intermediate ring is movable relative to the inner member in the axial direction. With respect to the vibration in the direction of a mounting shaft, the outer frame section, the intermediate ring and the elastic vibration isolating main body move together in the axial direction in relation to the inner member, whereby the spring in the direction of the mounting shaft is weakened and the resonance frequency of the rigid body resonance in the direction of the mounting shaft is decreased.

Abstract: A second inner member and a second insulator are provided in a second ring-shaped member forming a torque rod. A first bore section and a second bore section are provided in front of and in the rear of the second inner member. The insulator has an elastic arm section extending in the direction of a Y axis. A spring adjustment recess extends in a slit shape in the direction of an X axis from an end of the first bore section. The spring adjustment recess forms an unrestricted part of the elastic arm section by the second ring-shaped member, whereby the Z spring in the axial direction of the inner member is lowered, and the XZ spring ratio can be changed greatly while maintaining the size of the X spring in the main vibration inputting direction.

Abstract: A torque rod includes a rod main body, a first bushing and a second bushing. The rod main body is made of resin and provided integral with a first ring section and a second ring section on each end of an arm section. A first rib extends from the arm section to a front lateral surface of the second ring section. In a plan view, a second rib is provided to overlap with the first rib. The first rib projects forwardly of and in the left and right directions of the second rib. This projecting portion forms an enlarged diameter portion. Due to this enlarged diameter portion, an area of the first rib is made larger than an area of the second rib thereby to increase a rigidity of a forward side of the second ring.

Abstract: The onium salt of the present invention contains predetermined compound A represented by the general formula (1). The composition of the present invention contains the onium salt of the present invention, and an onium salt containing predetermined compound B represented by the general formula (2). The onium salt and the composition of the present invention exert well-balanced excellent physical properties in terms of cold curing properties, storage stability, thermal shock resistance after curing, and moisture resistance.

Abstract: A wire (12) is wound around multiple processing rollers (11) several times. A holding mechanism (13) and a depressing mechanism (25) are provided above an area where the wire (12) is wound. The holding mechanism (13) holds a workpiece (W) elastically and laterally. The depressing mechanism (25) depresses the workpiece (W) held by the holding mechanism (13) toward the wire (12).

Abstract: A second inner member and a second insulator are provided in a second ring-shaped member forming a torque rod. A first bore section and a second bore section are provided in front of and in the rear of the second inner member. The insulator has an elastic arm section extending in the direction of a Y axis. A spring adjustment recess extends in a slit shape in the direction of an X axis from an end of the first bore section. The spring adjustment recess forms an unrestricted part of the elastic arm section by the second ring-shaped member, whereby the Z spring in the axial direction of the inner member is lowered, and the XZ spring ratio can be changed greatly while maintaining the size of the X spring in the main vibration inputting direction.