Patents by Inventor Hitosi Agematu

Hitosi Agematu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated nucleic acid encoding L-lysine: 2-oxoglutaric acid 6-aminotransferase
    Patent number: 7235388
    Abstract: Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of Flavobacterium lutescens.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: June 26, 2007
    Assignee: Mercian Corporation
    Inventors: Tadashi Fujii, Takao Narita, Kuniho Nakata, Hitosi Agematu, Hiroshi Tsunekawa, Kunio Isshiki, Takeo Yoshioka
  • Process for the biological production of L-pipecolic acid
    Patent number: 7022502
    Abstract: A process for the production of L-pipecolic acid which comprises the step of reducing delta-1-piperideine-6-carboxylic acid by the use of pyrroline-5-carboxylate reductase. The delta-1-piperideine-6-carboxylic acid is obtained by the step of converting L-lysine by the use of lysine 6-aminotransferase encoded by a gene of Flavobacterium lutescens. The steps of reducing delta-1-piperideine-6-carboxylic acid and the converting of L-lysine into L-pipecolic acid by the use of lysine 6-aminotransferase are carried out by using a bacterium transformed with a gene encoding lysine 6-aminotransferase wherein such bacterium comprises pyrroline-5-carboxylate reductase encoded by a gene of Escherichia coli or a coryneform bacterium. A recombinant bacterium which can be used in this production process is also provided. Thus, the present invention can provide an efficient biological process for the production of L-pipecolic acid (or 2-piperidinecarboxylic acid).
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: April 4, 2006
    Assignee: Mercian Corporation
    Inventors: Tadashi Fujii, Yasuhide Aritoku, Manabu Mukaihara, Takao Narita, Hitosi Agematu, Kunio Isshiki
  • Gene participating in the production of homo-glutamic acid and utilization thereof
    Patent number: 6890746
    Abstract: Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of Flavobacterium lutescens.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: May 10, 2005
    Assignee: Mercian Corporation
    Inventors: Tadashi Fujii, Takao Narita, Kuniho Nakata, Hitosi Agematu, Hiroshi Tsunekawa, Kunio Isshiki, Takeo Yoshioka
  • Gene participating in the production of homoglutamic acid and its use
    Publication number: 20040214295
    Abstract: Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of Flavobacterium lutescens.
    Type: Application
    Filed: June 3, 2004
    Publication date: October 28, 2004
    Inventors: Tadashi Fujii, Takao Narita, Kuniho Nakata, Hitosi Agematu, Hiroshi Tsunekawa, Kunio Isshiki, Takeo Yoshioka
  • Process for the biological production of l-pipecolic acid
    Publication number: 20030207410
    Abstract: A process for the production of L-pipecolic acid which comprises the step of reducing delta-1-piperideine-6-carboxylic acid by the use of pyrroline-5-carboxylate reductase. A recombinant bacterium which can be used in this production process is also provided. Thus, the present invention can provide an efficient biological process for the production of L-pipecolic acid (or 2-piperidinecarboxylic acid).
    Type: Application
    Filed: June 28, 2002
    Publication date: November 6, 2003
    Inventors: Tadashi Fujii, Yasuhide Aritoku, Manabu Mukaihara, Takao Narita, Hitosi Agematu, Kunio Isshiki
  • Antibiotics Mer-AF1032A and Mer-AF1032B
    Patent number: 5232943
    Abstract: Antibiotic Mer-AF1032A represented by the following formula (I) and its isomer antibiotic Mer-AF1032B are disclosed. Also disclosed are a method for preparing the antibiotics comprising the cultivation of a strain belonging to genus Penicillium and a pharmaceutical composition comprising one of these antibiotics and useful as an antifungal agent.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: August 3, 1993
    Assignee: Mercian Corporation
    Inventors: Hitosi Agematu, Yoshio Watanabe, Hiroyuki Chiba, Rei Kaneto, Norio Shibamoto, Takeo Yoshioka, Toshihiko Kumamoto, Hiroshi Nishida, Rokuro Okamoto