Patents by Inventor Ho-Chul Yun
Ho-Chul Yun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240174636Abstract: Provided are a compound having a cyclohexyl-(alkyl or cycloalkyl-substituted)ethylene-amino-heteroaryl moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound or pharmaceutically acceptable salt thereof not only has excellent inhibitory activity against indoleamine 2,3-dioxygenase (IDO) but also exhibits remarkably high in vivo exposure upon oral administration and therefore the compound or pharmaceutically acceptable salt thereof can be usefully applied for preventing or treating various diseases associated with IDO.Type: ApplicationFiled: March 22, 2022Publication date: May 30, 2024Applicant: YUHAN CORPORATIONInventors: Gyu-Jin LEE, Eui-Chul LEE, Sol PARK, Dong-Hoon LEE, Su-Hwa KIM, Jong-Suk PARK, Ho-Woong KANG, Hyun-Sik YUN
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Patent number: 11742520Abstract: An electrochemical cell having a casing housing an electrode assembly of a separator residing between a lithium anode and a cathode comprising silver vanadium oxide and fluorinated carbon is described. The electrode assembly is activated with a nonaqueous electrolyte comprising a lithium salt dissolved in a solvent system of propylene carbonate mixed with 1,2-dimethoxyethane, dibenzyl carbonate (DBC), lithium bis(oxalato)borate (LiBOB), and fluoroethylene carbonate (FEC). Preferably DBC is present in an amount ranging from about 0.005 moles (M) to about 0.25M, LiBOB is present in an amount ranging from about 0.005 wt. 5 to about 5 wt. %, and FEC is present in an amount ranging from about 0.01 wt. % to about 10 wt. %. This electrolyte formulation is more conductive than the conventional or prior art binary and ternary solvent system electrolytes while being chemically and electrochemically stable toward Li/SVO cells, Li-SVO/CFx mixture cells, and Li-SVO/CFx sandwich cathode primary electrochemical cells.Type: GrantFiled: May 3, 2021Date of Patent: August 29, 2023Assignee: Greatbatch Ltd.Inventors: Robert S. Rubino, Joseph M. Lehnes, Marcus J. Palazzo, David M. Spillman, Ho-Chul Yun
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Patent number: 11735773Abstract: An electrochemical cell having a casing housing an electrode assembly of a separator residing between a lithium anode and a cathode comprising silver vanadium oxide and fluorinated carbon is described. The electrode assembly is activated with a nonaqueous electrolyte comprising a lithium salt dissolved in a solvent system of propylene carbonate mixed with 1,2-dimethoxyethane, lithium bis(oxalato)borate (LiBOB), and fluoroethylene carbonate (FEC). Preferably LiBOB is present in an amount ranging from about 0.005 wt. 5 to about 5 wt. %, and FEC is present in an amount ranging from about 0.01 wt. % to about 10 wt. %. This electrolyte formulation is more conductive than the conventional or prior art binary and ternary solvent system electrolytes while being chemically and electrochemically stable toward Li/SVO cells, Li-SVO/CFx mixture cells, and Li-SVO/CFx sandwich cathode primary electrochemical cells.Type: GrantFiled: March 15, 2021Date of Patent: August 22, 2023Assignee: Greatbatch Ltd.Inventors: Robert S. Rubino, Joseph M. Lehnes, Marcus J. Palazzo, David M. Spillman, Ho-Chul Yun
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Publication number: 20230114832Abstract: A miniature electrochemical cell of a secondary chemistry having a total volume that is less than 0.5 cc is described. Before the present invention, miniature secondary electrochemical cells have been known to experience undesirable open circuit voltage discharge during their initial 21-day aging period. It is believed that electrolyte permeating through the cathode active material and an intermediate carbonaceous coating contacting the titanium base plate of the casing is the source of the undesirable discharge. To ameliorate this, aluminum is contacted to the inner surface of the base plate inside the casing. While aluminum is resistant to the corrosion reaction that is believed to be the mechanism for degraded open circuit voltage in miniature secondary electrochemical cells containing lithium, it is not biocompatible. This means that titanium is still a preferred material for the casing parts including the base plate that might be exposed to body fluids, and the like.Type: ApplicationFiled: October 7, 2022Publication date: April 13, 2023Applicant: Greatbatch Ltd.Inventors: Lasantha Viyannalage, David Dianetti, Jared Arellano, Ho Chul Yun, Robert S. Rubino
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Patent number: 11527795Abstract: A miniature electrochemical cell having a total volume that is less than 0.5 cc is described. The cell casing is formed by joining two ceramic casing halves together. One or both casing halves are machined from ceramic to provide a recess that is sized and shaped to contain the electrode assembly. The opposite polarity terminals are metal feedthroughs, such as of gold, and are formed by brazing gold into openings machined into one or both of ceramic casing halves. A thin film metallization, such as of titanium, contacts an edge periphery of each ceramic casing half. The first ceramic casing half is moved into registry with the second ceramic casing half so that the first and second ring-shaped metallizations contact each other.Type: GrantFiled: February 12, 2020Date of Patent: December 13, 2022Assignee: Greatbatch Ltd.Inventors: Robert S. Rubino, Keith W. Seitz, Xiaohong Tang, Todd C. Sutay, Brian P. Hohl, Holly Noelle Moschiano, Biswa P. Das, Afsar Ali, Sourabh Biswas, Gary Freitag, David Dianetti, Ho-Chul Yun, Thomas Marzano
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Publication number: 20220166095Abstract: A miniature electrochemical cell of a primary or secondary chemistry with a total volume that is less than 0.5 cc is described. The cell casing comprises an annular sidewall connected to a base plate opposite an upper lid. A sealing glass forms a hermetic glass-to-ceramic seal with a dielectric material contacting a lower portion of the annular sidewall and a glass-to-metal seal with the base plate. Since the glass seals against three surfaces of the annular sidewall, which are the inner and outer sidewall surfaces adjacent to the lower edge, the glass seal is robust enough to withstand the heat generated when the lid is welded to the upper edge of the annular sidewall. The lid has a sealed electrolyte fill port that is axially aligned with an annulus residing between the inner surface of the annular sidewall and the electrode assembly.Type: ApplicationFiled: September 23, 2021Publication date: May 26, 2022Inventors: David Dianetti, Lasantha Viyannalage, Ho-Chul Yun, Robert S. Rubino, Marcus J. Palazzo, Jared Arellano
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Publication number: 20210359343Abstract: An electrochemical cell having a casing housing an electrode assembly of a separator residing between a lithium anode and a cathode comprising silver vanadium oxide and fluorinated carbon is described. The electrode assembly is activated with a nonaqueous electrolyte comprising a lithium salt dissolved in a solvent system of propylene carbonate mixed with 1,2-dimethoxyethane, dibenzyl carbonate (DBC), lithium bis(oxalato)borate (LiBOB), and fluoroethylene carbonate (FEC). Preferably DBC is present in an amount ranging from about 0.005 moles (M) to about 0.25M, LiBOB is present in an amount ranging from about 0.005 wt. 5 to about 5 wt. %, and FEC is present in an amount ranging from about 0.01 wt. % to about 10 wt. %. This electrolyte formulation is more conductive than the conventional or prior art binary and ternary solvent system electrolytes while being chemically and electrochemically stable toward Li/SVO cells, Li-SVO/CFx mixture cells, and Li-SVO/CFx sandwich cathode primary electrochemical cells.Type: ApplicationFiled: May 3, 2021Publication date: November 18, 2021Inventors: Robert S. Rubino, Joseph M. Lehnes, Marcus J. Palazzo, David M. Spillman, Ho-Chul Yun
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Patent number: 11075377Abstract: A lithium electrochemical cell with increased energy density is described. The electrochemical cell comprises an improved sandwich cathode design with a second cathode active material of a relatively high energy density but of a relatively low rate capability sandwiched between two current collectors and with a first cathode active material having a relatively low energy density but of a relatively high rate capability in contact with the opposite sides of the two current collectors. In addition, a cathode fabrication process is described that increases manufacturing efficiency. The cathode fabrication process comprises a process in which first and second cathode active materials are directly applied to opposite surfaces of a perforated current collector and laminated together. The present cathode design is useful for powering an implantable medical device requiring a high rate discharge application.Type: GrantFiled: March 7, 2019Date of Patent: July 27, 2021Assignee: Greatbatch Ltd.Inventors: Robert S. Rubino, William C. Thiebolt, Marcus J. Palazzo, Joseph M. Lehnes, Ho-Chul Yun, Mark J. Roy
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Patent number: 11075388Abstract: A current collector for an electrochemical cell is described. Unlike conventional current collector designs, the current collector does not have an unperforated perimeter frame completely bordering or surrounding a perforated interior region. Instead, only that portion of the current collector adjacent to the connector tab is unperforated. Otherwise, perforations extend directly to the perimeter edge.Type: GrantFiled: November 9, 2018Date of Patent: July 27, 2021Assignee: Greatbatch Ltd.Inventors: Mark J. Roy, Joseph M. Lehnes, Marcus J. Palazzo, Robert S. Rubino, William C. Thiebolt, Ho-Chul Yun
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Patent number: 11011787Abstract: A miniature electrochemical cell having a total volume that is less than 0.5 cc is described. The cell casing is formed by joining two ceramic casing halves together. One or both casing halves are machined from ceramic to provide a recess that is sized and shaped to contain the electrode assembly. The opposite polarity terminals are metal feedthroughs, such as of gold, and are formed by brazing gold into openings machined into one or both ceramic casing halves. The two ceramic casing halves are separated from each other by a metal interlayer, such as of gold, bonded to a thin film metallization adhesion layer, such as of titanium, that contacts an edge periphery of each ceramic casing half. A solid electrolyte (LixPOyNz) is used to activate the electrode assembly.Type: GrantFiled: January 4, 2019Date of Patent: May 18, 2021Assignee: Greatbatch Ltd.Inventors: Keith W. Seitz, Robert S. Rubino, Gary Freitag, David Dianetti, Todd C. Sutay, Ho-Chul Yun, Thomas Marzano, Brian P. Hohl
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Patent number: 10957884Abstract: A miniature electrochemical cell having a total volume that is less than 0.5 cc is described. The casing enclosure consists of a lower plate supporting a cylindrically-shaped can having an open upper end closed with a cover. The can is selectively coated with a dielectric material to provide electrical isolation of the to-be-housed active materials from the can sidewall. A glass-to-metal seal electrically isolates the lower plate from the can. An electrode assembly comprising a sandwich of cathode active material/separator/anode active material is housed in the casing. That way, the lower plate contacting the cathode active material is the positive terminal and the closing cover connected to the can and contacted to the anode active material serves as the negative cell terminal. An electrolyte filled into the casing activates the electrode assembly and the fill opening is sealed with a plug. The cell can be of either a primary or a secondary chemistry.Type: GrantFiled: January 7, 2019Date of Patent: March 23, 2021Assignee: Greatbatch Ltd.Inventors: David Dianetti, Gary Freitag, Robert S. Rubino, Keith W. Seitz, Ho-Chul Yun, Todd C. Sutay, Brian P. Hohl, David Wutz
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Publication number: 20200185662Abstract: A miniature electrochemical cell having a total volume that is less than 0.5 cc is described. The cell casing is formed by joining two ceramic casing halves together. One or both casing halves are machined from ceramic to provide a recess that is sized and shaped to contain the electrode assembly. The opposite polarity terminals are metal feedthroughs, such as of gold, and are formed by brazing gold into openings machined into one or both of ceramic casing halves. A thin film metallization, such as of titanium, contacts an edge periphery of each ceramic casing half. The first ceramic casing half is moved into registry with the second ceramic casing half so that the first and second ring-shaped metallizations contact each other.Type: ApplicationFiled: February 12, 2020Publication date: June 11, 2020Inventors: Robert S. Rubino, Keith W. Seitz, Xiaohong Tang, Todd C. Sutay, Brian P. Hohl, Holly Noelle Moschiano, Biswa P. Das, Afsar Ali, Sourabh Biswas, Gary Freitag, David Dianetti, Ho-Chul Yun, Thomas Marzano
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Patent number: 10403903Abstract: An electrochemical cell comprising a cathode and an anode residing within a casing, the anode being positioned distal of the cathode. The cathode having a cathode current collector having an angled configuration that encourages the cathode active material to move in an axial distal direction during cell discharge. The cathode current collector may be configured having at least one fold thereby dividing the current collector into at least two portions having an angle therebetween. The cathode current collector may comprise a wire having a helical configuration or the cathode current collector may comprise a post with a thread having a helical orientation about the post exterior. A preferred chemistry is a lithium/CFx activated with a nonaqueous electrolyte.Type: GrantFiled: June 12, 2017Date of Patent: September 3, 2019Assignee: Greatbatch Ltd.Inventors: Robert S. Rubino, Joseph M. Lehnes, Ho-Chul Yun
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Publication number: 20190214605Abstract: A miniature electrochemical cell having a total volume that is less than 0.5 cc is described. The cell casing is formed by joining two ceramic casing halves together. One or both casing halves are machined from ceramic to provide a recess that is sized and shaped to contain the electrode assembly. The opposite polarity terminals are metal feedthroughs, such as of gold, and are formed by brazing gold into openings machined into one or both ceramic casing halves. The two ceramic casing halves are separated from each other by a metal interlayer, such as of gold, bonded to a thin film metallization adhesion layer, such as of titanium, that contacts an edge periphery of each ceramic casing half. A solid electrolyte (LixPOyNz) is used to activate the electrode assembly.Type: ApplicationFiled: January 4, 2019Publication date: July 11, 2019Inventors: Keith W. Seitz, Robert S. Rubino, Gary Freitag, David Dianetti, Todd C. Sutay, Ho-Chul Yun, Thomas Marzano, Brian P. Hohl
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Publication number: 20190207199Abstract: A lithium electrochemical cell with increased energy density is described. The electrochemical cell comprises an improved sandwich cathode design with a second cathode active material of a relatively high energy density but of a relatively low rate capability sandwiched between two current collectors and with a first cathode active material having a relatively low energy density but of a relatively high rate capability in contact with the opposite sides of the two current collectors. In addition, a cathode fabrication process is described that increases manufacturing efficiency. The cathode fabrication process comprises a process in which first and second cathode active materials are directly applied to opposite surfaces of a perforated current collector and laminated together. The present cathode design is useful for powering an implantable medical device requiring a high rate discharge application.Type: ApplicationFiled: March 7, 2019Publication date: July 4, 2019Inventors: Robert S. Rubino, William C. Thiebolt, Marcus J. Palazzo, Joseph M. Lehnes, Ho-Chul Yun, Mark J. Roy
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Patent number: 10263240Abstract: A lithium electrochemical cell with increased energy density is described. The electrochemical cell comprises an improved sandwich cathode design with a second cathode active material of a relatively high energy density but of a relatively low rate capability sandwiched between two current collectors and with a first cathode active material having a relatively low energy density but of a relatively high rate capability in contact with the opposite sides of the two current collectors. In addition, a cathode fabrication process is described that increases manufacturing efficiency. The cathode fabrication process comprises a process in which first and second cathode active materials are directly applied to opposite surfaces of a perforated current collector and laminated together. The present cathode design is useful for powering an implantable medical device requiring a high rate discharge application.Type: GrantFiled: October 11, 2016Date of Patent: April 16, 2019Assignee: Greatbatch Ltd.Inventors: Robert S. Rubino, William C. Thiebolt, Marcus J. Palazzo, Joseph M. Lehnes, Ho-Chul Yun, Mark J. Roy
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Publication number: 20170358801Abstract: An electrochemical cell comprising a cathode and an anode residing within a casing, the anode being positioned distal of the cathode. The cathode having a cathode current collector having an angled configuration that encourages the cathode active material to move in an axial distal direction during cell discharge. The cathode current collector may be configured having at least one fold thereby dividing the current collector into at least two portions having an angle therebetween. The cathode current collector may comprise a wire having a helical configuration or the cathode current collector may comprise a post with a thread having a helical orientation about the post exterior. A preferred chemistry is a lithium/CFx activated with a nonaqueous electrolyte.Type: ApplicationFiled: June 12, 2017Publication date: December 14, 2017Inventors: Robert S. Rubino, Joseph M. Lehnes, Ho-Chul Yun
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Publication number: 20170104207Abstract: A lithium electrochemical cell with increased energy density is described. The electrochemical cell comprises an improved sandwich cathode design with a second cathode active material of a relatively high energy density but of a relatively low rate capability sandwiched between two current collectors and with a first cathode active material having a relatively low energy density but of a relatively high rate capability in contact with the opposite sides of the two current collectors. In addition, a cathode fabrication process is described that increases manufacturing efficiency. The cathode fabrication process comprises a process in which first and second cathode active materials are directly applied to opposite surfaces of a perforated current collector and laminated together. The present cathode design is useful for powering an implantable medical device requiring a high rate discharge application.Type: ApplicationFiled: October 11, 2016Publication date: April 13, 2017Inventors: Robert S. Rubino, William C. Thiebolt, Marcus J. Palazzo, Joseph M. Lehnes, Ho-Chul Yun, Mark J. Roy