Abstract: A method comprising (A) fragmenting genomic DNA in a state where the interaction of the genomic DNA and molecules interacting therewith is maintained, and (B) bringing genomic DNA into contact with an exogenous molecule capable of binding to a specific endogenous DNA sequence in the genomic DNA. According to the method, with the use of an endogenous DNA sequence present inside or in the vicinity of a target genomic region in cells to be analyzed, any genomic region can be specifically isolated in a state where the interaction of the genomic region and molecules interacting therewith is maintained, without the need of inserting a recognition sequence of an exogenous DNA-binding molecule into the vicinity of the target genomic region in the cells to be analyzed.

Abstract: The present invention provides a method for detecting a target nucleic acid that discriminates the target nucleic acid from a non-target nucleic acid having a nucleotide sequence or modification state that differs from a portion of the target nucleic acid, the method comprising conducting a nucleic acid amplification reaction using a region in the non-target nucleic acid that differs from the target nucleic acid as a target region, using a region in the target nucleic acid that differs from the non-target nucleic acid as a corresponding target region, using a nucleic acid test sample as a template, and using a primer that hybridizes with both the target nucleic acid and the non-target nucleic acid, with the nucleic acid amplification reaction conducted in the presence of a molecule capable of binding specifically to the target region in the non-target nucleic acid, under temperature conditions under which the molecule can bind to the non-target nucleic acid, and then detecting the target nucleic acid on the b

Abstract: A method comprising (A) fragmenting genomic DNA in a state where the interaction of the genomic DNA and molecules interacting therewith is maintained, and (B) bringing genomic DNA into contact with an exogenous molecule capable of binding to a specific endogenous DNA sequence in the genomic DNA. According to the method, with the use of an endogenous DNA sequence present inside or in the vicinity of a target genomic region in cells to be analyzed, any genomic region can be specifically isolated in a state where the interaction of the genomic region and molecules interacting therewith is maintained, without the need of inserting a recognition sequence of an exogenous DNA-binding molecule into the vicinity of the target genomic region in the cells to be analyzed.

Abstract: Provided is a method for detecting a variation of a reference sequence in a target nucleic acid region, the method comprising the steps of: performing a template-dependent nucleic acid amplification reaction for amplifying a region containing the reference sequence using, as a template, a nucleic acid containing the target nucleic acid region, in the presence of a 10 to 200 nucleotide single-stranded nucleic acid capable of hybridizing with the reference sequence in the target nucleic acid region, and examining the presence or absence of an amplified product, wherein the single-stranded nucleic acid is RNA or a chimeric nucleic acid composed of RNA and one or more different nucleic acids, wherein the single-stranded nucleic acid contains a sequence complementary to the reference sequence, and wherein the single-stranded nucleic acid has a higher complementarity to the reference sequence than to a variant sequence having a variation of the reference sequence.

Abstract: Provided is a method for detecting a variation of a reference sequence in a target nucleic acid region, the method comprising the steps of: performing a template-dependent nucleic acid amplification reaction for amplifying a region containing the reference sequence using, as a template, a nucleic acid containing the target nucleic acid region, in the presence of a 10 to 200 nucleotide single-stranded nucleic acid capable of hybridizing with the reference sequence in the target nucleic acid region, and examining the presence or absence of an amplified product, wherein the single-stranded nucleic acid is RNA or a chimeric nucleic acid composed of RNA and one or more different nucleic acids, wherein the single-stranded nucleic acid contains a sequence complementary to the reference sequence, and wherein the single-stranded nucleic acid has a higher complementarity to the reference sequence than to a variant sequence having a variation of the reference sequence.

Abstract: Provided is a method comprising (A) fragmenting genomic DNA in a state where the interaction of the genomic DNA and molecules interacting therewith is maintained, and (B) bringing genomic DNA into contact with an exogenous molecule capable of binding to a specific endogenous DNA sequence in the genomic DNA. According to the method, with the use of an endogenous DNA sequence present inside or in the vicinity of a target genomic region in cells to be analyzed, any genomic region can be specifically isolated in a state where the interaction of the genomic region and molecules interacting therewith is maintained, without the need of inserting a recognition sequence of an exogenous DNA-binding molecule into the vicinity of the target genomic region in the cells to be analyzed.

Abstract: Provided is a method for specifically isolating any genomic region while maintaining interaction of the genomic region with its interacting molecule(s).

Abstract: Provided is a method for specifically isolating any genomic region while maintaining interaction of the genomic region with its interacting molecule(s).

Abstract: The present invention relates to a novel method for screening to identify/detect polypeptides capable of translocating into or out of the nucleus of a cell in response to induction by an external stimulus or stimuli. Kits for practicing the method of the invention are also encompassed by the present invention.

Abstract: The present invention relates to a novel method for screening to identify/detect polypeptides capable of translocating into or out of the nucleus of a cell in response to induction by an external stimulus or stimuli. Kits for practicing the method of the invention are also encompassed by the present invention.