Patents by Inventor Hodaka Makino
Hodaka Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946034Abstract: A sterile sampling apparatus includes a first to seventh flow paths, a sampling section, a first and second pumps, and a first to sixth opening/closing mechanism. The sampling section is disposed in the seventh flow path. The first pump is disposed in the sixth flow path. The second pump is disposed in the seventh flow path. The second flow path includes a first opening/closing mechanism. The third flow path includes a second opening/closing mechanism. The fourth flow path includes a third opening/closing mechanism. The first flow path includes a fourth opening/closing mechanism. The sixth flow path includes a fifth opening/closing mechanism. The seventh flow path includes a sixth opening/closing mechanism. The rate of the second pump is higher than that of the first pump.Type: GrantFiled: July 20, 2020Date of Patent: April 2, 2024Assignee: Nihon Kohden CorporationInventors: Hodaka Makino, Hirotsugu Kubo
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Publication number: 20230035766Abstract: The presently disclosed subject matter provides a cell culture evaluation system including a measurement unit, a first storage unit, a second storage unit, an evaluation unit and an output unit, wherein: the measurement unit includes a sensor that acquires evaluation target data about motion or a state of a culture tool; the first storage unit stores the evaluation target data; the second storage unit stores reference data; the evaluation unit compares the evaluation target data with the reference data so as to evaluate an execution state of a cell culture process; and the output unit outputs an evaluation result created by the evaluation unit.Type: ApplicationFiled: December 21, 2020Publication date: February 2, 2023Inventors: Hodaka Makino, Hirotsugu Kubo, Masahiro Kinooka
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Patent number: 11505774Abstract: A sample storage apparatus includes: a lid member; a sample storage container; first and second fluid sucking sections; first and second fluid discharging sections; first to fourth flow paths; and a first fluid identification sensor. The first flow path is connected to the first fluid sucking section, the second flow path is connected to the second fluid sucking section, the third flow path is connected to the first fluid discharging section, and the fourth flow path is connected to the second fluid discharging section. The first fluid identification sensor for identifying a fluid is disposed in the first flow path.Type: GrantFiled: October 22, 2019Date of Patent: November 22, 2022Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITYInventors: Hodaka Makino, Hirotsugu Kubo, Tetsuya Ogawa, Masahiro Kinooka
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Patent number: 11318456Abstract: An aseptic sampling apparatus includes an isolator, a liquid delivery port that is disposed in the isolator, a sampling section that is disposed inside the isolator, a first flow path that communicates with a discharge flow path of the sampling section, and that connects an inside and outside of the isolator to each other through the liquid delivery port, a fluid supplying unit that supplies a fluid to the sampling section, a gas supplying unit that communicates with the fluid supplying unit, and a seal member that prevents the fluid supplied from fluid supplying unit to the discharge flow path from leaking.Type: GrantFiled: January 3, 2019Date of Patent: May 3, 2022Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITYInventors: Hodaka Makino, Hirotsugu Kubo, Tetsuya Ogawa, Masahiro Kinooka
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Patent number: 11320344Abstract: An aseptic sampling flow path kit to be applied to an isolator having a liquid delivery port includes a sampling section, a first flow path that communicates with the sampling section, and that connects an inside of the isolator to an outside of the isolator through the liquid delivery port, and at least one one-way valve which is disposed in the first flow path, and that limits flow of fluid in the first flow path to a direction from the sampling section toward the liquid delivery port. In the kit, at least a part of the first flow path is a germicidal flow path to which a germicidal unit is applicable.Type: GrantFiled: January 2, 2019Date of Patent: May 3, 2022Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITYInventors: Hodaka Makino, Hirotsugu Kubo, Masahiro Kinooka
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Patent number: 11312935Abstract: An object of the present disclosure is to provide a cell culture system, a cell culture environment evaluation device, and a program, capable of performing evaluation of a culture environment without causing an adverse effect on cell culture. An isolator is provided with a culture environment for housing a cell culture vessel having a culture solution containing cells to be cultured placed therein. A sensing unit measures the state of the culture environment and transmits the measurement result of the culture environment to the outside of the isolator. A control device receives the measurement result and performs evaluation in the culture environment based on the measurement result.Type: GrantFiled: December 26, 2017Date of Patent: April 26, 2022Assignee: Nihon Kohden CorporationInventors: Hodaka Makino, Wataru Matsuzawa
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Patent number: 11313851Abstract: A device for measuring a tension of a cell structure containing muscle cells includes a first and a second gel adaptor holder. The first gel adaptor holder includes a frame member and a first gel holding portion which is disposed protrudingly from a part of an inner surface of the frame member for fixing one end of a gel. The second gel adaptor holder includes a second gel holding portion that fixes another end of the gel, and connecting members connected with the second gel holding portion. A kit including the device, a substrate and a gel forming cover. The substrate includes a pair of gel shaping convex parts fitted along the inner surface of the frame member. The gel forming cover includes a surface parallel to a gel contacting surface of the substrate, in order to form an upper surface of the gel.Type: GrantFiled: February 27, 2020Date of Patent: April 26, 2022Assignee: NIHON KOHDEN CORPORATIONInventors: Hirotsugu Kubo, Takahiro Shioyama, Yuki Kagawa, Yuto Hinata, Hodaka Makino
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Publication number: 20210285935Abstract: A tension measuring device include a first container in which a cell structure is disposed and which is charged with a culture medium so that the cell structure is immersed therein; a second container in which a medical agent to be given to the inside of the first container is injected; a first tube which links the first container and the second container liquidtightly; and a pump which is disposed over the first tube and causes liquid to flow into the first container from the second container.Type: ApplicationFiled: March 8, 2021Publication date: September 16, 2021Applicant: NIHON KOHDEN CORPORATIONInventors: Hodaka MAKINO, Tetsuya OGAWA
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Publication number: 20210024869Abstract: A sterile sampling apparatus includes a first to seventh flow paths, a sampling section, a first and second pumps, and a first to sixth opening/closing mechanism. The sampling section is disposed in the seventh flow path. The first pump is disposed in the sixth flow path. The second pump is disposed in the seventh flow path. The second flow path includes a first opening/closing mechanism. The third flow path includes a second opening/closing mechanism. The fourth flow path includes a third opening/closing mechanism. The first flow path includes a fourth opening/closing mechanism. The sixth flow path includes a fifth opening/closing mechanism. The seventh flow path includes a sixth opening/closing mechanism. The rate of the second pump is higher than that of the first pump.Type: ApplicationFiled: July 20, 2020Publication date: January 28, 2021Inventors: Hodaka MAKINO, Hirotsugu KUBO
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Publication number: 20200278342Abstract: A device for measuring a tension of a cell structure containing muscle cells includes a first and a second gel adaptor holder. The first gel adaptor holder includes a frame member and a first gel holding portion which is disposed protrudingly from a part of an inner surface of the frame member for fixing one end of a gel. The second gel adaptor holder includes a second gel holding portion that fixes another end of the gel, and connecting members connected with the second gel holding portion. A kit including the device, a substrate and a gel forming cover. The substrate includes a pair of gel shaping convex parts fitted along the inner surface of the frame member. The gel forming cover includes a surface parallel to a gel contacting surface of the substrate, in order to form an upper surface of the gel.Type: ApplicationFiled: February 27, 2020Publication date: September 3, 2020Applicant: NIHON KOHDEN CORPORATIONInventors: Hirotsugu Kubo, Takahiro Shioyama, Yuki Kagawa, Yuto Hinata, Hodaka Makino
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Publication number: 20200123489Abstract: A sample storage apparatus includes: a lid member; a sample storage container; first and second fluid sucking sections; first and second fluid discharging sections; first to fourth flow paths; and a first fluid identification sensor. The first flow path is connected to the first fluid sucking section, the second flow path is connected to the second fluid sucking section, the third flow path is connected to the first fluid discharging section, and the fourth flow path is connected to the second fluid discharging section. The first fluid identification sensor for identifying a fluid is disposed in the first flow path.Type: ApplicationFiled: October 22, 2019Publication date: April 23, 2020Applicants: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITYInventors: Hodaka MAKINO, Hirotsugu KUBO, Tetsuya OGAWA, Masahiro KINOOKA
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Publication number: 20190250073Abstract: An aseptic sampling flow path kit to be applied to an isolator having a liquid delivery port includes a sampling section, a first flow path that communicates with the sampling section, and that connects an inside of the isolator to an outside of the isolator through the liquid delivery port, and at least one one-way valve which is disposed in the first flow path, and that limits flow of fluid in the first flow path to a direction from the sampling section toward the liquid delivery port. In the kit, at least a part of the first flow path is a germicidal flow path to which a germicidal unit is applicable.Type: ApplicationFiled: January 2, 2019Publication date: August 15, 2019Applicants: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITYInventors: Hodaka MAKINO, Hirotsugu KUBO, Masahiro KINOOKA
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Publication number: 20190247842Abstract: An aseptic sampling apparatus includes an isolator, a liquid delivery port that is disposed in the isolator, a sampling section that is disposed inside the isolator, a first flow path that communicates with a discharge flow path of the sampling section, and that connects an inside and outside of the isolator to each other through the liquid delivery port, a fluid supplying unit that supplies a fluid to the sampling section, a gas supplying unit that communicates with the fluid supplying unit, and a seal member that prevents the fluid supplied from fluid supplying unit to the discharge flow path from leaking.Type: ApplicationFiled: January 3, 2019Publication date: August 15, 2019Applicants: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITYInventors: Hodaka MAKINO, Hirotsugu KUBO, Tetsuya OGAWA, Masahiro KINOOKA
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Publication number: 20180371396Abstract: An object of the present disclosure is to provide a cell culture system, a cell culture environment evaluation device, and a program, capable of performing evaluation of a culture environment without causing an adverse effect on cell culture. An isolator is provided with a culture environment for housing a cell culture vessel having a culture solution containing cells to be cultured placed therein. A sensing unit measures the state of the culture environment and transmits the measurement result of the culture environment to the outside of the isolator. A control device receives the measurement result and performs evaluation in the culture environment based on the measurement result.Type: ApplicationFiled: December 26, 2017Publication date: December 27, 2018Applicant: NIHON KOHDEN CORPORATIONInventors: Hodaka Makino, Wataru Matsuzawa