Patents by Inventor Holger Enderle

Holger Enderle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of an oral bolus in the drying-off of dairy cattle
    Patent number: 11890374
    Abstract: Described herein is an oral bolus for drying-off cattle, preferably dairy cattle, as well as methods of improving/facilitating the drying-off of cattle, reducing the milk production in pregnant and/or lactating cattle, decreasing milk accumulation in the udder of cattle, increasing the daily lying time of cattle, inducing a mild and temporary metabolic acidosis in cattle, reducing the dry matter intake (DMI) in cattle and/or reducing urine pH in cattle, preferably dairy cattle, including administering to such cattle at least one oral bolus, preferably on the last milking day and/or before dry-off.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: February 6, 2024
    Inventors: Daniel Zaspel, Juergen Bubeck, Holger Enderle, Laurent Goby, Leif Hoejvang-Nielsen
  • USE OF AN ORAL BOLUS IN THE DRYING-OFF OF DAIRY CATTLE
    Publication number: 20210177747
    Abstract: Described herein is an oral bolus for drying-off cattle, preferably dairy cattle, as well as methods of improving/facilitating the drying-off of cattle, reducing the milk production in pregnant and/or lactating cattle, decreasing milk accumulation in the udder of cattle, increasing the daily lying time of cattle, inducing a mild and temporary metabolic acidosis in cattle, reducing the dry matter intake (DMI) in cattle and/or reducing urine pH in cattle, preferably dairy cattle, including administering to such cattle at least one oral bolus, preferably on the last milking day and/or before dry-off.
    Type: Application
    Filed: March 2, 2021
    Publication date: June 17, 2021
    Inventors: Daniel ZASPEL, Juergen BUBECK, Holger ENDERLE, Laurent GOBY, Leif HOEJVANG-NIELSEN
  • Use of an oral bolus in the drying-off of dairy cattle
    Patent number: 10966921
    Abstract: The invention relates to the use of an oral bolus for drying-off cattle, preferably daily cattle, as well as methods of improving/facilitating the drying-off of cattle, reducing the milk production in pregnant and/or lactating cattle, decreasing milk accumulation in the udder of cattle, increasing the daily lying time of cattle, inducing a mild and temporary metabolic acidosis in cattle, reducing the dry matter intake (DMI) in cattle and/or reducing urine pH in cattle, preferably dairy cattle, comprising administering to such cattle at least one oral bolus, preferably on the last milking day and/or before dry-off.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: April 6, 2021
    Inventors: Daniel Zaspel, Juergen Bubeck, Holger Enderle, Laurent Goby, Leif Hoejvang-Nielsen
  • USE OF AN ORAL BOLUS IN THE DRYING-OFF OF DAIRY CATTLE
    Publication number: 20190358154
    Abstract: The invention relates to the use of an oral bolus for drying-off cattle, preferably daily cattle, as well as methods of improving/facilitating the drying-off of cattle, reducing the milk production in pregnant and/or lactating cattle, decreasing milk accumulation in the udder of cattle, increasing the daily lying time of cattle, inducing a mild and temporary metabolic acidosis in cattle, reducing the dry matter intake (DMI) in cattle and/or reducing urine pH in cattle, preferably dairy cattle, comprising administering to such cattle at least one oral bolus, preferably on the last milking day and/or before dry-off.
    Type: Application
    Filed: May 20, 2019
    Publication date: November 28, 2019
    Inventors: Daniel ZASPEL, Juergen BUBECK, Holger ENDERLE, Laurent GOBY, Leif HOEJVANG-NIELSEN
  • Pyrrolidone derivatives for use as MetAP-2 inhibitors
    Patent number: 8846694
    Abstract: Compounds of the formula (I), in which R, X, Y, Z, R3 and R4 have the meanings indicated in claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: September 30, 2014
    Assignee: Merck Patent GmbH
    Inventors: Timo Heinrich, Mireille Krier, Thorsten Knoechel, Alfred Jonczyk, Frank Zenke, Holger Enderle
  • Novel pyrrolidone derivatives for use as MetAP-2 inhibitors
    Publication number: 20110263561
    Abstract: Compounds of the formula (I), in which R, X, Y, Z, R3 and R4 have the meanings indicated in claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
    Type: Application
    Filed: May 13, 2009
    Publication date: October 27, 2011
    Applicant: Merck Patent GmbH
    Inventors: Timo Heinrich, Mireille Krier, Thorsten Knoechel, Alfred Jonczyk, Frank Zenke, Holger Enderle
  • SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES
    Publication number: 20100120818
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, R5, and R6 and m have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: February 21, 2008
    Publication date: May 13, 2010
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventor: Holger Enderle