Patents by Inventor Hon Siu Shin
Hon Siu Shin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10835901Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.Type: GrantFiled: June 30, 2017Date of Patent: November 17, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Hon Siu Shin, Chin Yong Koo, Way Xuang Lee, Chee Kiong Lim, Chee Wee Ching, Niroshan Ramachandran
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Publication number: 20190126281Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.Type: ApplicationFiled: August 29, 2018Publication date: May 2, 2019Inventors: Yong CHU, Jeffrey MARKS, Jacob FREUDENTHAL, Mingsong CHEN, Tiong Han TOH, Mauro AGUANNO, Lik Seng LAU, Lian Seng LOH, Kok Siong TEO, Zeng Wei CHU, Xin MATHERS, Michael UY, Huei Steven YEO, Kuan Moon BOO, Way Xuang LEE, Chin Yong KOO, Wei Fuh TEO, Soo Yong LAU, Hon Siu SHIN, Zeqi TAN, Thomas WESSEL, David WOO
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Publication number: 20180311672Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: June 27, 2018Publication date: November 1, 2018Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 10010887Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: GrantFiled: October 10, 2014Date of Patent: July 3, 2018Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Publication number: 20180056296Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.Type: ApplicationFiled: June 30, 2017Publication date: March 1, 2018Inventors: Hon Siu SHIN, Chin Yong KOO, Way Xuang LEE, Chee Kiong LIM, Chee Wee CHING, Niroshan RAMACHANDRAN
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Patent number: 9855558Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.Type: GrantFiled: April 30, 2013Date of Patent: January 2, 2018Assignee: APPLIED BIOSYSTEM, LLCInventors: Hon Siu Shin, Hock Lai Khoo
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Patent number: 9457351Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.Type: GrantFiled: March 12, 2014Date of Patent: October 4, 2016Assignee: Applied Biosystems, LLCInventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Wolfgang Heimberg
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Publication number: 20160228876Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.Type: ApplicationFiled: February 5, 2016Publication date: August 11, 2016Inventors: Yong Chu, Jeffrey Marks, Jacob Freudenthal, Mingsong Chen, Tiong Han Toh, Mauro Aguanno, Lik Seng Lau, Lian Seng Loh, Kok Siong Teo, Zeng Wei Chu, Xin Mathers, Michael Uy, Huei Yeo, Kuan Moon Boo, Way Xuang Lee, Chin Yong Koo, Wei Fuh Teo, Soo Yong Lau, Hon Siu Shin, Zeqi Tan, Thomas Wessel, Woo David
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Publication number: 20160214110Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.Type: ApplicationFiled: September 15, 2014Publication date: July 28, 2016Inventors: Hon Siu SHIN, Chin Yong KOO, Way Xuang LEE, Chee Kiong LIM, Chee Wee CHING, Niroshan RAMACHANDRAN
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Publication number: 20150024479Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: October 10, 2014Publication date: January 22, 2015Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 8859271Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: GrantFiled: February 16, 2011Date of Patent: October 14, 2014Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Publication number: 20140273182Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Wolfgang Heimberg
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Patent number: 8676383Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.Type: GrantFiled: September 5, 2007Date of Patent: March 18, 2014Assignee: Applied Biosystems, LLCInventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Ching Ong Lau, Wolfgang Heimberg
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Publication number: 20130230915Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.Type: ApplicationFiled: April 30, 2013Publication date: September 5, 2013Applicant: APPLIED BIOSYSTEM, LLCInventors: Hon Siu SHIN, Hock Lai KHOO
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Patent number: 8440454Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.Type: GrantFiled: April 27, 2011Date of Patent: May 14, 2013Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Hock Lai Khoo
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Publication number: 20110200501Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.Type: ApplicationFiled: April 27, 2011Publication date: August 18, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Hon Siu SHIN, Hock Lai Khoo
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Publication number: 20110136219Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: February 16, 2011Publication date: June 9, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Hon Siu SHIN, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 7935524Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.Type: GrantFiled: January 29, 2010Date of Patent: May 3, 2011Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Hock Lai Khoo
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Publication number: 20100129876Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.Type: ApplicationFiled: January 29, 2010Publication date: May 27, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Hon Siu SHIN, Hock Lai KHOO
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Patent number: 7659109Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.Type: GrantFiled: May 17, 2004Date of Patent: February 9, 2010Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Hock Lai Khoo