Patents by Inventor Hon Siu Shin

Hon Siu Shin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10835901
    Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: November 17, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Hon Siu Shin, Chin Yong Koo, Way Xuang Lee, Chee Kiong Lim, Chee Wee Ching, Niroshan Ramachandran
  • Publication number: 20190126281
    Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
    Type: Application
    Filed: August 29, 2018
    Publication date: May 2, 2019
    Inventors: Yong CHU, Jeffrey MARKS, Jacob FREUDENTHAL, Mingsong CHEN, Tiong Han TOH, Mauro AGUANNO, Lik Seng LAU, Lian Seng LOH, Kok Siong TEO, Zeng Wei CHU, Xin MATHERS, Michael UY, Huei Steven YEO, Kuan Moon BOO, Way Xuang LEE, Chin Yong KOO, Wei Fuh TEO, Soo Yong LAU, Hon Siu SHIN, Zeqi TAN, Thomas WESSEL, David WOO
  • Publication number: 20180311672
    Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
    Type: Application
    Filed: June 27, 2018
    Publication date: November 1, 2018
    Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
  • Patent number: 10010887
    Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: July 3, 2018
    Assignee: Applied Biosystems, LLC
    Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
  • Publication number: 20180056296
    Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.
    Type: Application
    Filed: June 30, 2017
    Publication date: March 1, 2018
    Inventors: Hon Siu SHIN, Chin Yong KOO, Way Xuang LEE, Chee Kiong LIM, Chee Wee CHING, Niroshan RAMACHANDRAN
  • Patent number: 9855558
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 2, 2018
    Assignee: APPLIED BIOSYSTEM, LLC
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Patent number: 9457351
    Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 4, 2016
    Assignee: Applied Biosystems, LLC
    Inventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Wolfgang Heimberg
  • Publication number: 20160228876
    Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 11, 2016
    Inventors: Yong Chu, Jeffrey Marks, Jacob Freudenthal, Mingsong Chen, Tiong Han Toh, Mauro Aguanno, Lik Seng Lau, Lian Seng Loh, Kok Siong Teo, Zeng Wei Chu, Xin Mathers, Michael Uy, Huei Yeo, Kuan Moon Boo, Way Xuang Lee, Chin Yong Koo, Wei Fuh Teo, Soo Yong Lau, Hon Siu Shin, Zeqi Tan, Thomas Wessel, Woo David
  • Publication number: 20160214110
    Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.
    Type: Application
    Filed: September 15, 2014
    Publication date: July 28, 2016
    Inventors: Hon Siu SHIN, Chin Yong KOO, Way Xuang LEE, Chee Kiong LIM, Chee Wee CHING, Niroshan RAMACHANDRAN
  • Publication number: 20150024479
    Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 22, 2015
    Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
  • Patent number: 8859271
    Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: October 14, 2014
    Assignee: Applied Biosystems, LLC
    Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
  • Publication number: 20140273182
    Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Wolfgang Heimberg
  • Patent number: 8676383
    Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.
    Type: Grant
    Filed: September 5, 2007
    Date of Patent: March 18, 2014
    Assignee: Applied Biosystems, LLC
    Inventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Ching Ong Lau, Wolfgang Heimberg
  • Publication number: 20130230915
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Application
    Filed: April 30, 2013
    Publication date: September 5, 2013
    Applicant: APPLIED BIOSYSTEM, LLC
    Inventors: Hon Siu SHIN, Hock Lai KHOO
  • Patent number: 8440454
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: May 14, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Publication number: 20110200501
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Application
    Filed: April 27, 2011
    Publication date: August 18, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Hon Siu SHIN, Hock Lai Khoo
  • Publication number: 20110136219
    Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
    Type: Application
    Filed: February 16, 2011
    Publication date: June 9, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Hon Siu SHIN, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
  • Patent number: 7935524
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: May 3, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Publication number: 20100129876
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Application
    Filed: January 29, 2010
    Publication date: May 27, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Hon Siu SHIN, Hock Lai KHOO
  • Patent number: 7659109
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: February 9, 2010
    Assignee: Applied Biosystems, LLC
    Inventors: Hon Siu Shin, Hock Lai Khoo